What's truly minimally invasive in benign prostatic hyperplasia surgery?

Chung, Amanda; Woo, Henry H.

doi:10.1097/mou.0000000000000006

Cited by 19 publications

(7 citation statements)

References 16 publications

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“…While intraprostatic injection of different agents is considered a minimally invasive technique in lower urinary tract symptoms associated with benign prostatic hyperplasia, further studies on the efficacy of more novel agents are needed [12]. Mechanical devices such as Urolift are also emerging for patients who desire to save their sexual function or cannot tolerate surgery [13]. Recently, there has been an increasing interest in novel agents for intraprostatic injection.…”

Section: Discussionmentioning

confidence: 99%

Stereological comparison of intraprostatic injection of alcohol and bleomycin with finasteride gavages in the rats

Eslahi

Noorafshan

Safarpour

et al. 2017

CEJU

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IntroductionResection of the prostate is one of the standard surgical treatments for symptomatic Benign Prostatic Hyperplasia (BPH). To evaluate minimally invasive treatments, intraprostatic injections of ethanol and bleomycin were compared with oral finasteride administration in rats with BPH.Material and methodsThe rats were divided into six groups. The control rats received no BPH/no treatment. BPH was induced using injections of testosterone (2 mg/day/rat for 4 weeks) in groups II–VI. After 4 weeks, Group II received no treatment while Group III received oral finasteride (10 mg/kg/day).Moreover, Groups IV–VI received a single injection of ethanol (95%), bleomycin (5 mg/kg) and normal saline 25 mm3 in each ventral lobe of the prostate respectively. Two weeks after the injections, the ventral lobes underwent a quantitative stereological study.ResultsThe volume of the ventral lobes, glandular epithelium, fibromuscular tissue and microvessles increased by 1.7, 3.1, 2.4 and 1.6 times in BPH rats respectively (P <0.01). Alcohol or bleomycin injection in PBH rats induced drastic recession of the increased volume of the ventral lobe, glandular epithelium and fibromuscular tissue (P <0.01). Regarding the BPH+alcohol group, the glandular epithelium volume restored to the normal values of the control rats (P <0.01). BPH+finasteride also incited an atrophic change in the volume of the whole prostate and glandular epithelium, but not the fibromuscular tissue and microvessels (P <0.01).ConclusionsInjection of alcohol and bleomycin (approximately 10% of the volume of ventral prostatic) as well as consuming finasteride can induce a reduction of 1/3, 1/4 and 1/5 in the hypertrophied gland respectively.

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Section: Discussionmentioning

confidence: 99%

Stereological comparison of intraprostatic injection of alcohol and bleomycin with finasteride gavages in the rats

Eslahi

Noorafshan

Safarpour

et al. 2017

CEJU

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“…New emerging techniques such as UroLift (NeoTract, Inc., Pleasanton, CA, USA), Rezum (N X Thera, Maple Grove, MN, USA), prostatic emolization, and prostatic injectable drugs have gained wide attention in the urologic community. These techniques usually do not remove prostatic tissue immediately, or ever, and only unobstruct a small but seemingly relevant part of the prostatic fossa [4]. Despite encouraging results, the crucial question is, ''How long and for what price?''…”

Section: Experts' Commentsmentioning

confidence: 98%

Re: GreenLight™ Laser (XPS) Photoselective Vapo-enucleation Versus Holmium Laser Enucleation of the Prostate for the Treatment of Symptomatic Benign Prostate Hyperplasia: A Randomized Controlled Study

Bachmann

Rieken

2015

European Urology

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“…One concern regarding prostatic ethanol ablation is the difficulty in controlling distribution and the potential risk of bladder necrosis due to inadvertent injection [14,15] . Use of anhydrous ethanol in a gel formulation has been described as a potential solution to this problem.…”

Section: Ethanol Ablationmentioning

confidence: 99%