What shapes the oral jaws? Accommodation of complex dentition correlates with premaxillary but not mandibular shape

Hammer, Christine; Atukorallaya, Devi; Franz‐Odendaal, Tamara A.

doi:10.1016/j.mod.2016.04.001

Cited by 8 publications

(4 citation statements)

References 34 publications

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“…The cartilaginous elements of the developing jaw structures of this species can be observed as early as 2.5 dpf in both morphs (Hinaux et al, ). The A. mexicanus lower jaw develops from Meckel's cartilage; the premaxillary and the maxillary bones ossify in association with the ethmoid and palatoquadrate cartilage (Atukorala and Franz‐Odendaal, ; Hammer et al, ). These cartilaginous elements are gradually replaced by intramembranous and perichondral ossification (Atukorala and Franz‐Odendaal, ).…”

Section: Bones With Life‐long Tooth Replacementmentioning

confidence: 99%

“…These cartilaginous elements are gradually replaced by intramembranous and perichondral ossification (Atukorala and Franz‐Odendaal, ). Hammer et al () analyzed the bone stain growth series of the jaw bones of the surface morphs and found that the premaxilla ossified first followed by the dentary and the maxilla (Hammer et al, ). The primary ossification areas in SF were in a different sequence from those observed in zebrafish jaw development.…”

Section: Bones With Life‐long Tooth Replacementmentioning

confidence: 99%

See 1 more Smart Citation

Craniofacial skeleton of MEXICAN tetra (Astyanax mexicanus): As a bone disease model

Atukorallaya

Bhatia

Ratnayake

2018

Developmental Dynamics

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A small fresh water fish, the Mexican tetra (Astyanax mexicanus) is a novel animal model in evolutionary developmental biology. The existence of morphologically distinct surface and cave morphs of this species allows simultaneous comparative analysis of phenotypic changes at different life stages. The cavefish harbors many favorable constructive traits (i.e., large jaws with an increased number of teeth, neuromast cells, enlarged olfactory pits and excess storage of adipose tissues) and regressive traits (i.e., reduced eye structures and pigmentation) which are essential for cave adaptation. A wide spectrum of natural craniofacial morphologies can be observed among the different cave populations. Recently, the Mexican tetra has been identified as a human disease model. The fully sequenced genome along with modern genome editing tools has allowed researchers to generate transgenic and targeted gene knockouts with phenotypes that resemble human pathological conditions. This review will discuss the anatomy of the craniofacial skeleton of A. mexicanus with a focus on morphologically variable facial bones, jaws that house continuously replacing teeth and pharyngeal skeleton. Furthermore, the possible applications of this model animal in identifying human congenital and metabolic skeletal disorders is addressed. Developmental Dynamics 248:153‐161, 2019. © 2018 Wiley Periodicals, Inc.

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Section: Bones With Life‐long Tooth Replacementmentioning

confidence: 99%

Section: Bones With Life‐long Tooth Replacementmentioning

confidence: 99%

Craniofacial skeleton of MEXICAN tetra (Astyanax mexicanus): As a bone disease model

Atukorallaya

Bhatia

Ratnayake

2018

Developmental Dynamics

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“…As noted earlier, unique suites of genes pattern upper and lower jaws; the genetic integration of tooth/jaw tissues may also be jaw specific (Boughner and Uppal, ). Different programs may integrate Evo‐Devo change between each jaw and its dentition, including responses to feeding strategies (Boughner, ; Hammer et al., ). Thus, developmental genetic variation is raw material for selection while, as will be explained just below, oral function helps integrate growing jaws, catalyzes phenotypic plasticity in an individual, and drives adaptive oral macroevolution in a population.…”

Section: Malocclusion: a Point Of Human Evo‐devo Pride?mentioning

confidence: 99%

Implications of Vertebrate Craniodental Evo‐Devo for Human Oral Health

Boughner

2017

J Exp Zool Pt B

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Highly processed diets eaten by postindustrial modern human populations coincide with higher frequencies of third molar impaction, malocclusion, and temporomandibular joint disorders that affect millions of people worldwide each year. Current treatments address symptoms, not causes, because the multifactorial etiologies of these three concerns mask which factors incline certain people to malocclusion, impaction, and/or joint issues. Deep scientific curiosity about the origins of jaws and dentitions continues to yield rich insights about the developmental genetic mechanisms that underpin healthy craniodental morphogenesis and integration. Mounting evidence from evolution and development (Evo-Devo) studies suggests that function is another mechanism important to healthy craniodental integration and fit. Starting as early as weaning, softer diets and thus lower bite forces appear to relax or disrupt integration of oral tissues, alter development and growth, and catalyze impaction, malocclusion, and jaw joint disorders. How developing oral tissues respond to bite forces remains poorly understood, but biomechanical feedback seems to alter balances of local bone resorption and deposition at the tooth-bone interface as well as affect tempos and amounts of facial outgrowth. Also, behavioral changes in jaw function and parafunction contribute to degeneration and pain in joint articular cartilages and masticatory muscles. The developmental genetic contribution to craniodental misfits and disorders is undeniable but still unclear; however, at present, human diet and jaw function remain important and much more actionable clinical targets. New Evo-Devo studies are needed to explain how function interfaces with craniodental phenotypic plasticity, variation, and evolvability to yield a spectrum of healthy and mismatched dentitions and jaws.

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“…Many of the same genes are conserved in both dentitions (Yamanaka, Iwai, Uemura, & Goto, ) yet some of these genes are differently expressed in developing maxillary versus mandibular teeth (Ferguson, Tucker, & Sharpe, ; Jia et al, ; Thomas et al, ). Recent work in fish found that premaxilla shape correlated strongly with dental phenotype while mandible shape did not, evidence of jaw‐specific patterns of tooth/jaw integration (Hammer, Atukorala, & Franz‐Odendaal, ). Such differences may help explain how upper and lower teeth can evolve independently in terms of size, shape, and number.…”

Section: Introductionmentioning

confidence: 99%

Upper jaw development in the absence of teeth: New insights for craniodental evo‐devo integration

Phen

Greer

Uppal

et al. 2018

Evolution and Development

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In p63-null mice (p63 ), teeth fail to form but the mandible forms normally; conversely, the upper jaw skeleton is malformed. Here we explored whether lack of dental tissues contributed to midfacial dysmorphologies in p63 mice by testing if facial prominence defects appeared before odontogenesis failed. We also investigated gene dose effects by testing if one wild type (WT) p63 allele (p63 ) was sufficient for normal upper jaw skeleton formation. We micro-CT scanned PFA-fixed p63 , p63 , and WT (p63 ) adult and embryonic mice aged E10-E14. Next, we landmarked mandibular (MdP), maxillary (MxP) and nasal prominences (NPs), and facial bones. 3D landmark data were assessed using Principal Component, Canonical Variate, Partial Least Squares, and other statistical analyses. The p63 embryos showed MxP and NP malformations by E12, despite the presence of dental tissues. MdP shape was comparable among p63 , p63 , and p63 embryos. Upper jaw shape was comparable between p63 and p63 adults. The upper jaw and its dentition both require p63 signaling, but not each other's presence, to form properly. One WT p63 allele enables normal midfacial morphogenesis; gene dose may be a target for jaw macroevolution. Jaw-specific genetic mechanisms likely integrate the evo-devo of dentitions with upper versus lower jaws.

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What shapes the oral jaws? Accommodation of complex dentition correlates with premaxillary but not mandibular shape

Cited by 8 publications

References 34 publications

Craniofacial skeleton of MEXICAN tetra (Astyanax mexicanus): As a bone disease model

Craniofacial skeleton of MEXICAN tetra (Astyanax mexicanus): As a bone disease model

Implications of Vertebrate Craniodental Evo‐Devo for Human Oral Health

Upper jaw development in the absence of teeth: New insights for craniodental evo‐devo integration

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