The purpose of this review is to synthesize existing literature to analyze the influence of the Adverse Childhood Experiences (ACEs), including the COVID-19 pandemic, and toxic stress on child development and lifelong health outcomes of Latinx children in the USA, utilizing the ACE framework. Without adequate protective factors, children's early experiences with adversity and toxic stress have implications for their physiological, psychological, and social health. The COVID-19 pandemic has shown to exacerbate childhood adversity and toxic stress and has disproportionately harmed Latinx communities. In applying the ACE framework to US-Latinx populations, relevant findings concerning a potential failure of ACEs to accurately capture Latinx experiences of adversity were highlighted, as well as the need to classify the COVID-19 pandemic as an ACE. Research suggest that firstgeneration Latinx immigrants report lower-than-average rates of ACEs despite the various disparities ethnic minorities face in the USA. A discussion on whether this health paradox arises because of the failure of ACEs to properly identify adverse experiences unique to immigrants or if it is related with immigrant families' protective cultural factors. The compounding experiences of discrimination, immigration anxieties, and now also pandemic-related hardship that have the potential to harm Latinx children's cognitive, emotional, and physical development were highlighted. Evidence-based interventions that were discussed in this report include promotion of resiliency through healthy adult relationships, policies that screen for ACEs early on in a child's life, trauma-informed care and innovative treatment programs, and strengthening existing protective services through financial and political support.