A new inpatient secondary preventive program for patients with musculoskeletal health problems was introduced throughout Austria. The aim of the current work was to evaluate this "Health Prevention Active" program and its possible influences on the quality of medical results upon hospital discharge.This observational study presents monocentric data for 7448 patients (48.99 ± 6.15 years; 53.7% women) with chronic musculoskeletal disorders who completed a 3-week health program. The focus was placed on measuring medical quality outcomes such as BMI, blood pressure, heart rate, pain, subjective ratings, and achieved power output in cycle ergometer exercise testing. We describe pre-post changes before and after the inpatient program and the results of a follow-up survey conducted after 1 year to identify moderating factors related to health outcomes.The medical baseline showed obvious deficits regarding obesity, hypertension, and subjective symptoms. Of all patients, 36.5% were completely inactive. The patient's gender and physical activity had a high impact on the medical baseline status. In total, the majority of patients (86.2%; SMD = -0.78 ± 0.59) responded well to the health prevention program, independent of their ages and lifestyles.Requirements for secondary prevention programs are high. The results of the study reflect the general problems presented by inactivity, obesity, and subjective symptoms like pain. Physical activity was specifically identified as a major factor for the observed medical baseline status. Abbreviations: h p 2 = effect size (partial Eta 2 ), ADL = activities of daily living, BMI = body mass index, EC = Ethics Committee, GHI = general health index (mean value of MED1, MED2, MED3; z), GVA = "Gesundheitsvorsorge Aktiv" ["Health Prevention Active" program], h = hours, ICD = International statistical classification of diseases and related health problems, idx = index for outcome (z), ISI = indication specific index (mean value of MED4, MED5; z), IV = initial value (baseline, pre), MED1 = shape indicator of MQO (BMI and waist circumference; z), MED2 = cardiovascular indicator of MQO (RR and RHR; z), MED3 = subjective indicator of MQO (VAS and EQ-VAS; z), MED4 = performance indicator of MQO (ergometer power in watts; z), MED5 = ADL indicator of MQO (EQ-5D; z), MQO = medical quality outcome (mean value of GHI and ISI; z), N (n) = sample size, P = significance level (risk of error), PA = physical activity, r = correlation coefficient (Pearson), RHR = resting heart rate, RR = Riva-Rocci (abbreviation for blood pressure measurements), Editor: Sinan Kardes.