What to know about Omicron XBB.1.5

Vogel, Lauren

doi:10.1503/cmaj.1096034

Cited by 16 publications

(28 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 5 Since September 2022, BA.5 has caused a new global wave of infection, which is still one of the dominating strains in some countries such as China. 5 , 24 , 35 Omicron variants are featured by high mutation rate, high transmissibility, and immune evasion. 2 What's more, a complex connection was observed among different Omicron variants.…”

Section: Discussionmentioning

confidence: 99%

“…A typical example is the combination or fusion of two BA.2 sublineages: BA.2.10.1 and BA.2.75, which created the XBB sublineage with increased resistance to host immunity but hampered ability to infect host cells. 35 , 36 XBB.1.5 has further evolved from XBB with higher affinity to host cells while continuing to evade the bodies’ antiviral immunity, making it the most contagious variant of SARS‐CoV‐2 so far. 35 Since its first discovery in late 2022, it has overtaken other circulating strains and become dominant in the USA in such a short time.…”

Section: Discussionmentioning

confidence: 99%

“… 35 , 36 XBB.1.5 has further evolved from XBB with higher affinity to host cells while continuing to evade the bodies’ antiviral immunity, making it the most contagious variant of SARS‐CoV‐2 so far. 35 Since its first discovery in late 2022, it has overtaken other circulating strains and become dominant in the USA in such a short time. It is likely that XBB.1.5 will be the cause of the next global wave of COVID‐19 in the foreseeable future.…”

Section: Discussionmentioning

confidence: 99%

“…Different from other VOCs, Omicron variants have evolved with considerable diversity and are now categorized into five lineages based on the chronological order of appearance, including BA.1, BA.2, BA.3, BA.4, and BA.5 5 . Since September 2022, BA.5 has caused a new global wave of infection, which is still one of the dominating strains in some countries such as China 5,24,35 . Omicron variants are featured by high mutation rate, high transmissibility, and immune evasion 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Intra‐VOC recombination events are very common, creating upgraded generations of Omicron sublineages. A typical example is the combination or fusion of two BA.2 sublineages: BA.2.10.1 and BA.2.75, which created the XBB sublineage with increased resistance to host immunity but hampered ability to infect host cells 35,36 . XBB.1.5 has further evolved from XBB with higher affinity to host cells while continuing to evade the bodies’ antiviral immunity, making it the most contagious variant of SARS‐CoV‐2 so far 35 .…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

A recombinant spike‐XBB.1.5 protein vaccine induces broad‐spectrum immune responses against XBB.1.5‐included Omicron variants of SARS‐CoV‐2

Alu

Hong

et al. 2023

MedComm

View full text Add to dashboard Cite

The XBB.1.5 subvariant has drawn great attention owing to its exceptionality in immune evasion and transmissibility. Therefore, it is essential to develop a universally protective coronavirus disease 2019 vaccine against various strains of Omicron, especially XBB.1.5. In this study, we evaluated and compared the immune responses induced by six different spike protein vaccines targeting the ancestral or various Omicron strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice. We found that spike-wild-type immunization induced high titers of neutralizing antibodies (NAbs) against ancestral SARS-CoV-2. However, its activity in neutralizing Omicron subvariants decreased sharply as the number of mutations in receptor-binding domain (RBD) of these viruses increased. Spike-BA.5, spike-BF.7, and spike-BQ.1.1 vaccines induced strong NAbs against BA.5, BF.7, BQ.1, and BQ.1.1 viruses but were poor in protecting against XBB and XBB.1.5, which have more RBD mutations. In sharp contrast, spike-XBB.1.5 vaccination can activate strong and broadly protective immune responses against XBB.1.5 and other common subvariants of Omicron. By performing correlation analysis, we found that the NAbs titers were negatively correlated with the number of RBD mutations in the Omicron subvariants. Vaccines with more RBD mutations can effectively overcome the immune resistance caused by the accumulation of RBD mutations, making spike-XBB.1.5 the most promising vaccine candidate against universal Omicron variants.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

A recombinant spike‐XBB.1.5 protein vaccine induces broad‐spectrum immune responses against XBB.1.5‐included Omicron variants of SARS‐CoV‐2

Alu

Hong

et al. 2023

MedComm

View full text Add to dashboard Cite

show abstract

Analyzing the emerging patterns of SARS‐CoV‐2 Omicron subvariants for the development of next‐gen vaccine: An observational study

Mohapatra,

Mishra,

Kandi

et al. 2023

Health Science Reports

View full text Add to dashboard Cite

Background and AimUnderstanding the prevalence and impact of SARS‐CoV‐2 variants has assumed paramount importance. This study statistically analyzed to effectively track the emergence and spread of the variants and highlights the importance of such investigations in developing potential next‐gen vaccine to combat the continuously emerging Omicron subvariants.MethodsTransmission fitness advantage and effective reproductive number (Re) of epidemiologically relevant SARS‐CoV‐2 sublineages through time during the study period based on the GISAID data were estimated.ResultsThe analyses covered the period from January to June 2023 around an array of sequenced samples. The dominance of the XBB variant strain, accounting for approximately 57.63% of the cases, was identified during the timeframe. XBB.1.5 exhibited 37.95% prevalence rate from March to June 2023. Multiple variants showed considerable global influence throughout the study, as sporadically documented. Notably, the XBB variant demonstrated an estimated relative 28% weekly growth advantage compared with others. Numerous variants were resistant to the over‐the‐counter vaccines and breakthrough infections were reported. Similarly, the efficacy of mAB‐based therapy appeared limited. However, it's important to underscore the perceived benefits of these preventive and therapeutic measures were restricted to specific variants.ConclusionGiven the observed trends, a comprehensive next‐gen vaccine coupled with an advanced vaccination strategy could be a potential panacea in the fight against the pandemic. The findings suggest that targeted vaccine development could be an effective strategy to prevent infections. The study also highlights the need of global collaborations to rapidly develop and distribute the vaccines to ensure global human health.

show abstract

Development of practical techniques for simultaneous detection and distinction of current and emerging SARS-CoV-2 variants

Fan

Liu

et al. 2023

ANAL. SCI.

View full text Add to dashboard Cite

What to know about Omicron XBB.1.5

Cited by 16 publications

References 0 publications

A recombinant spike‐XBB.1.5 protein vaccine induces broad‐spectrum immune responses against XBB.1.5‐included Omicron variants of SARS‐CoV‐2

A recombinant spike‐XBB.1.5 protein vaccine induces broad‐spectrum immune responses against XBB.1.5‐included Omicron variants of SARS‐CoV‐2

Analyzing the emerging patterns of SARS‐CoV‐2 Omicron subvariants for the development of next‐gen vaccine: An observational study

Development of practical techniques for simultaneous detection and distinction of current and emerging SARS-CoV-2 variants

Contact Info

Product

Resources

About