The research on cavitation bubbles within droplets has gradually become one of the advanced topics in the field of confined fluid domains, which is closely related to the industry fields. However, the research on the relationship between cavitation bubbles collapsing within droplet and droplet splash dynamics is still in its infancy. Here, the high-speed photography experimental platform of cavitation bubbles within droplets was built to investigate the influences of the eccentricities of bubbles within droplets on the phenomenon. The concluding remarks are given as follows. (1) With the change in eccentricity, the droplet splash morphology can be divided into three cases: scattering, trident, and composite splashes respectively. Moreover, the movement trend of the bubble wall can be divided into three categories: spherical, fabiform, and ellipsoidal. (2) The height of the main peak of the droplet splash and the distribution law of the splash angle could be changed by the eccentricity. (3) The bubble collapse time of the droplet is significantly affected by the eccentricity.