What Will Noninvasive Carotid Atherosclerosis Imaging Show Us About High-Risk Coronary Plaques?

Yuan, Chun; Polissar, Nayak L.; Hatsukami, Thomas S.

doi:10.1016/j.jacc.2011.02.061

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…Carotid ultrasound or MRI has been proposed as a method of identifying "vulnerable plaques." [135,136] MRI may also be a future method to measure extent of coronary artery disease [137,138]. Carotid IMT has been proposed as an alternative to coronary calcium because of lower cost, no radiation exposure and better quantitative screening.…”

Section: Imaging Of Atherosclerosismentioning

confidence: 99%

Imaging of Coronary Arteries Aid in Prevention of Atherosclerosis and Clinical Coronary Heart Disease

Kuller¹,

Edmundowicz²

2011

TOEPIJ

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Prevention of progression of atherosclerosis is the best approach to reduce incidence of myocardial infarction, sudden coronary heart disease (CHD) death, stroke and peripheral vascular disease. Research over the past 40 years has identified the risk factors for atherosclerotic disease, noninvasive methods for measuring the extent of atherosclerosis in multiple vascular beds and very efficacious therapy to reduce the level of risk factors and prevent cardiovascular diseases. Cardiovascular incidence and death rates have declined. Nevertheless, rates of CHD and other vascular disease remain much higher in many countries and within select regions of certain countries than necessary. Prevention of atherosclerosis depends on 4 key steps: 1) a much more aggressive effort to lower modifiable risk factors, especially apolipoprotein-B (ApoB)-containing lipoproteins, low density lipoprotein (LDL) particles, LDL cholesterol, blood pressure, obesity, and smoking during adolescence and young adult years; 2) identify and treat elevated ApoB lipoproteins, diabetes and smoking cessation of very high risk young adults as early as possible; 3) use of imaging to identify atherosclerosis of coronary and other arteries for appropriate segments of the adult population and treatment of risk factors for those with identifiable atherosclerosis; and 4) improved approaches to deliver prevention of cardiovascular disease to large numbers of asymptomatic individuals identified by non invasive imaging to maximize adherence to therapies. The major missing piece is better methods to identify vulnerable coronary plaques on the verge of an atherothrombotic transition and better treatments to prevent “acute” events. However, the four steps above will still lead to very substantial reductions in CHD incidence and mortality.

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Section: Imaging Of Atherosclerosismentioning

confidence: 99%

Imaging of Coronary Arteries Aid in Prevention of Atherosclerosis and Clinical Coronary Heart Disease

Kuller¹,

Edmundowicz²

2011

TOEPIJ

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“…A validation study is needed before use of NIRS in common clinical practice. Finally, research is required to determine whether vulnerable, non-stenotic, carotid LCP could be detected by NIRS or other methods and treated in advance to prevent strokes [ 15 ].…”

mentioning

confidence: 99%

First-in-man near-infrared spectroscopy proof of lipid-core embolization during carotid artery stenting

Horváth¹,

Hájek²,

Muller³

et al. 2016

aoms

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“…CIMT has commonly been used as a measure of subclinical atherosclerosis to assess cardiovascular disease risk. [61] In fact, increases in CIMT have been shown to be associated with increased risk of cardiovascular events. [62,63] Though focal plaque is often a clinical concern, CIMT is more strongly heritable than carotid plaque after adjustment for risk factors.…”

Section: Carotid Intima Medial Thickness (Cimt)mentioning

confidence: 99%

Understanding the genetics of coronary artery disease through the lens of noninvasive imaging

Yang¹,

Vargas²,

Bluemke³

2012

Expert Review of Cardiovascular Therapy

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Summary Coronary artery disease is a common disease with a known heritable component that has spurred interest in genetic research for decades, resulting in a handful of candidate genes and an appreciation for the complexity of its genetic contributions. Recent advances in sequencing technologies have made large scale association studies possible adding to our current understanding of the genetics of coronary artery disease. Sifting through the statistical noise, however, requires selecting effective phenotypic markers. New imaging technologies have improved our ability to detect subclinical atherosclerosis in a safe and reproducible manner in large numbers of patients. We propose here that advances in imaging technology have generated improved phenotypic markers for genetic association studies of coronary artery disease.

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What Will Noninvasive Carotid Atherosclerosis Imaging Show Us About High-Risk Coronary Plaques?

Cited by 5 publications

References 24 publications

Imaging of Coronary Arteries Aid in Prevention of Atherosclerosis and Clinical Coronary Heart Disease

Imaging of Coronary Arteries Aid in Prevention of Atherosclerosis and Clinical Coronary Heart Disease

First-in-man near-infrared spectroscopy proof of lipid-core embolization during carotid artery stenting

Understanding the genetics of coronary artery disease through the lens of noninvasive imaging

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