What will studies of Fulani individuals naturally exposed to malaria teach us about protective immunity to malaria?

Arama, Charles; Quin, Jaclyn; Bujila, Ioana; Farrants, Ann‐Kristin Östlund

doi:10.1111/sji.12932

Cited by 7 publications

(2 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An association of the SNPs with MM was further detected when considering age as a covariate (P < 0.001); it should be stressed, nevertheless, that controls and mild malaria patients did not differ in age (P = 0.22). Furthermore, the proportion of the Fulani ethnic group was calculated in the control group and in the patient group because membership in the Fulani group reduces the risk of clinical malaria [ 28 ]. There was no imbalance between the control group and the patient group with respect to ethnic group membership (P = 0.25).…”

Section: Resultsmentioning

confidence: 99%

ATP2B4 regulatory genetic variants are associated with mild malaria

Thiam

Nisar

Adjemout

et al. 2023

Malar J

View full text Add to dashboard Cite

Background Genome-wide association studies have identified ATP2B4 as a severe malaria resistance gene. Recently, 8 potential causal regulatory variants have been shown to be associated with severe malaria. Methods Genotyping of rs10900585, rs11240734, rs1541252, rs1541253, rs1541254, rs1541255, rs10751450, rs10751451 and rs10751452 was performed in 154 unrelated individuals (79 controls and 75 mild malaria patients). rs10751450, rs10751451 and rs10751452 were genotyped by Taqman assays, whereas the fragment of the ATP2B4 gene containing the remaining SNPs was sequenced. Logistic regression analysis was used to assess the association between the SNPs and mild malaria. Results The results showed that mild malaria was associated with rs10900585, rs11240734, rs1541252, rs1541253, rs1541254, rs1541255, rs10751450, rs10751451 and rs10751452. The homozygous genotypes for the major alleles were associated with an increased risk of mild malaria. Furthermore, the haplotype containing the major alleles and that containing the minor alleles were the most frequent haplotypes. Individuals with the major haplotypes had a significantly higher risk of mild malaria compared to the carriers of the minor allele haplotype. Conclusions ATP2B4 polymorphisms that have been associated with severe malaria are also associated with mild malaria.

show abstract

Section: Resultsmentioning

confidence: 99%

ATP2B4 regulatory genetic variants are associated with mild malaria

Thiam

Nisar

Adjemout

et al. 2023

Malar J

View full text Add to dashboard Cite

show abstract

“…Much data has been gathered on human Plasmodium infections clearly demonstrate functional activity of innate cells against iRBCs. The contribution of innate immune responses to P. falciparum in the Fulani tribe in Sub-Saharan Africa has been attributed to their greater resistance to infection compared with more susceptible sympatric ethnic groups [138] and innate responses to P. falciparum in CHMI studies has been associated with subsequent control of both iRBCs and clinical symptoms [139]. In P. falciparum blood stage infection, innate cells of the myeloid lineage [140][141][142], neutrophils [143,144], natural killer (NK) [145][146][147][148][149] and γδ-T cells [150] have all been shown to neutralize iRBCs.…”

Section: The Importance Of Innate Immune Cells In Irbc Controlmentioning

confidence: 99%

Mouse Models for Unravelling Immunology of Blood Stage Malaria

Olatunde¹,

Cornwall²,

Roedel³

et al. 2022

Preprint

View full text Add to dashboard Cite

Malaria comprises a spectrum of disease syndromes and the immune system is a major participant in malarial disease. This is particularly true in relation to the immune responses elicited against blood stages of Plasmodium-parasites that are responsible for the pathogenesis of infection. Mouse models of malaria are commonly used to dissect the immune mechanisms underlying disease. While no one mouse model of Plasmodium infection completely recapitulates all the features of malaria in humans, collectively the existing models are invaluable for defining the events that lead to the immunopathogenesis of malaria. Here we review the different mouse models of Plasmodium infection that are available, and highlight some of the main contributions these models have made with regards to identifying immune mechanisms of parasite control and the immunopathogenesis of malaria.

show abstract