What you do not know Could Hurt You: What Women Wish their Doctors Had Told them about Chemotherapy Side Effects on Memory and Response to Alcohol

Couvertier-Lebron, Carmen E.; Dove, Rachel; Acevedo, Summer F.

doi:10.4137/bcbcr.s38389

Cited by 3 publications

(3 citation statements)

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“…In addition, alcohol is well known to have neurotoxic, cardiotoxic, and hepatotoxic effects . Among patients undergoing chemotherapy, alcohol has been suggested to worsen cognition and cardiotoxicity . Furthermore, alcohol use is associated with hepatic dysfunction and regulates cytochrome enzymatic activity, which is important for the metabolism of chemotherapeutic agents and possibly alters their effectiveness or toxic effects.…”

Section: Discussionmentioning

confidence: 99%

“…[54][55][56] Among patients undergoing chemotherapy, alcohol has been suggested to worsen cognition and cardiotoxicity. 57,58 Furthermore, alcohol use is associated with hepatic dysfunction and regulates cytochrome enzymatic activity, 54 which is important for the metabolism of chemotherapeutic agents and possibly alters their effectiveness or toxic effects. Although the association of alcohol use with immunotherapy for cancer is unclear, the treatment outcomes may be somewhat affected due to alcohol-induced immune dysfunction.…”

Section: Jama Network Open | Oncologymentioning

confidence: 99%

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Alcohol Consumption Among Adults With a Cancer Diagnosis in the All of Us Research Program

et al. 2023

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ImportanceAlcohol consumption is associated with adverse oncologic and treatment outcomes among individuals with a diagnosis of cancer. As a key modifiable behavioral factor, alcohol consumption patterns among cancer survivors, especially during treatment, remain underexplored in the United States.ObjectiveTo comprehensively characterize alcohol consumption patterns among US cancer survivors.Design, Setting, and ParticipantsThis cross-sectional study used data from May 6, 2018, to January 1, 2022, from the National Institutes of Health All of Us Research Program, a diverse US cohort with electronic health record (EHR) linkage, and included 15 199 participants who reported a cancer diagnosis and 1839 patients among a subset with EHR data who underwent treatment within the past year of the baseline survey. Data analysis was performed from October 1, 2022, to January 31, 2023.Main Outcomes and MeasuresPrevalence of current drinking and of risky drinking behaviors, including exceeding moderate drinking (&gt;2 drinks on a typical drinking day), binge drinking (≥6 drinks on 1 occasion), and hazardous drinking (Alcohol Use Disorders Identification Test–Consumption [AUDIT-C] score ≥3 for women or ≥4 for men).ResultsThis study included 15 199 adults (mean [SD] age at baseline, 63.1 [13.0] years; 9508 women [62.6%]) with a cancer diagnosis. Overall, 11 815 cancer survivors (77.7%) were current drinkers. Among current drinkers, 1541 (13.0%) exceeded moderate drinking, 2812 (23.8%) reported binge drinking, and 4527 (38.3%) engaged in hazardous drinking. After multivariable adjustment, survivors who were younger than 65 years, men, or of Hispanic ethnicity or who received a diagnosis before 18 years of age or ever smoked were more likely to exceed moderate drinking (aged &lt;50 years: odds ratio [OR], 2.90 [95% CI, 2.41-3.48]; aged 50-64 years: OR, 1.84 [95% CI, 1.58-2.15]; men: OR, 2.38 [95% CI, 2.09-2.72]; Hispanic ethnicity: OR, 1.31 [95% CI, 1.04-1.64]; aged &lt;18 years at diagnosis: OR, 1.52 [95% CI, 1.04-2.24]; former smokers: OR, 2.46 [95% CI, 2.16-2.79]; current smokers: OR, 4.14 [95% CI, 3.40-5.04]) or binge drink (aged &lt;50 years: OR, 4.46 [95% CI, 3.85-5.15]; aged 50-64 years: OR, 2.15 [95% CI, 1.90-2.43]; men: OR, 2.10 [95% CI, 1.89-2.34]; Hispanic ethnicity: OR, 1.31 [95% CI, 1.09-1.58]; aged &lt;18 years at diagnosis: OR, 1.71 [95% CI, 1.24-2.35]; former smokers: OR, 1.69 [95% CI, 1.53-1.87]; current smokers: OR, 2.27 [95% CI, 1.91-2.71]). Survivors with cancer diagnosed before 18 years of age or who ever smoked were more likely to be hazardous drinkers (aged &lt;18 years at diagnosis: OR, 1.52 [95% CI, 1.11-2.08]; former smokers: OR, 1.83 [95% CI, 1.68-1.99]; current smokers: OR, 2.13 [95% CI, 1.79-2.53]). Of 1839 survivors receiving treatment as captured in the EHR, 1405 (76.4%) were current drinkers, and among these, 170 (12.1%) exceeded moderate drinking, 329 (23.4%) reported binge drinking, and 540 (38.4%) engaged in hazardous drinking, with similar prevalence across different types of cancer treatment.Conclusions and RelevanceThis cross-sectional study of a diverse US cohort suggests that alcohol consumption and risky drinking behaviors were common among cancer survivors, even among individuals receiving treatment. Given the adverse treatment and oncologic outcomes associated with alcohol consumption, additional research and implementation studies are critical in addressing this emerging concern among cancer survivors.

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Section: Discussionmentioning

confidence: 99%

Section: Jama Network Open | Oncologymentioning

confidence: 99%

Alcohol Consumption Among Adults With a Cancer Diagnosis in the All of Us Research Program

et al. 2023

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“…84,85 Furthermore, patients report an altered sensitivity to alcohol during receipt of chemotherapy, and may experience greater cognitive declines. 86,87 Interestingly, however, habitual alcohol consumption may be associated with a lower incidence of chemotherapy-induced nausea and vomiting. 88 Overall, more research is needed to more clearly define the risks of alcohol consumption during cancer treatment.…”

Section: Footnotes For Simin-3 Simin-3amentioning

confidence: 99%

NCCN Guidelines® Insights: Survivorship, Version 1.2022

Sanft

Day

Peterson

et al. 2022

Journal of the National Comprehensive Cancer Network

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The NCCN Guidelines for Survivorship are intended to help healthcare professionals who work with survivors to ensure that the survivors’ complex and varied needs are addressed. The NCCN Guidelines provide screening, evaluation, and treatment recommendations for the consequences of adult-onset cancer and its treatment; recommendations to help promote physical activity, weight management, and immunizations in survivors; and a framework for care coordination. This article summarizes updates to the NCCN Guidelines pertaining to preventive health for cancer survivors, including recommendations about alcohol consumption and vaccinations.

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Adherence to lifestyle recommendations among Norwegian cancer survivors and the impact of traditional and complementary medicine use: the Tromsø Study 2015–2016

Nakandi,

Benebo,

Hopstock

et al. 2023

BMC Complement Med Ther

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Introduction Adherence to healthy lifestyle recommendations has positive effects on cancer outcomes yet adherence is low among cancer survivors. Differences in adherence between women and men, phase of survivorship, and other factors that might increase adherence, like the use of traditional and complementary medicine (T&CM), need to be explored. We aimed to study the adherence to national recommendations for a healthy diet (daily intake of ≥ 5 portions of fruit/vegetables), physical activity (150 min of moderate-intensity or 75 min of high-intensity/week), normal body mass index (BMI) (18.5–24.9 kg/m2), non-smoking, and low-risk alcohol consumption (women ≤ 10 g/day, men ≤ 20 g/day) among Norwegian cancer survivors and their associations with sex, the use of T&CM, and survivorship phase. Methods We used logistic regression, independent sample t-test, and chi-square test to study self-reported (diet, physical activity, smoking, alcohol consumption) and measured (BMI) adherence in 1530 cancer survivors (40 years and above, participating in the population-based Tromsø Study conducted in 2015–2016 (65% attendance). We dichotomized all assessed lifestyle recommendations (adherence = 1 point, non-adherence = 0 points), and created a score for every recommendation (0–5 points). Adherence to individual lifestyle recommendations and the use of T&CM as well as the phase of survivorship was adjusted for sex, age, income, and living with a partner. Results Adherence to recommendations was 7.5% for diet, 85.3% for physical activity, 30.5% for BMI, 89.3% for non-smoking, and 87.6% for alcohol consumption. In total 2.3% adhered to all five recommendations concurrently (mean score 2.96 [SD = 0.86]). Women adhered to more recommendations concurrently compared to men (3.03 [SD = 0.90] vs. 2.89 [SD = 0.80] points respectively, [p = .012]). In total, 31% reported the use of T&CM and there were no differences in adherence to individual lifestyle recommendations or concurrent adherence in overall T&CM use compared to non-use. Users of self-help techniques were more likely to adhere to the recommendations of diet (aOR 2.69, 95% CI 1.45–4.98) and physical activity (aOR 6.26, 95% CI 1.51–25.92). Users of traditional healers and users of more than one T&CM modality were less likely to adhere to the low-risk alcohol consumption recommendation, (aOR 0.32, 95% CI 0.13–0.77, and aOR 0.53, 95% CI 1.08–2.17, respectively) compared to T&CM non-users. Survivors with cancer previously (1162) had higher odds of adhering to the recommendation of diet (aOR 2.66, 95% CI 1.36–5.19) than survivors with cancer presently (n = 368), but not to other recommendations. Conclusion The health of cancer survivors can be improved through adherence to lifestyle recommendations, yet our study found partial adherence among survivors in Norway, in accordance with findings from other countries. Although overall T&CM use was not associated with higher adherence to lifestyle recommendations, differences in adherence were seen among individual modalities like the use of self-help techniques and traditional healers. Our results suggest the need for intensified follow-up of lifestyle with attention to male survivors and diet among all survivors throughout the cancer survivorship continuum.

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What you do not know Could Hurt You: What Women Wish their Doctors Had Told them about Chemotherapy Side Effects on Memory and Response to Alcohol

Cited by 3 publications

References 46 publications

Alcohol Consumption Among Adults With a Cancer Diagnosis in the All of Us Research Program

Alcohol Consumption Among Adults With a Cancer Diagnosis in the All of Us Research Program

NCCN Guidelines® Insights: Survivorship, Version 1.2022

Adherence to lifestyle recommendations among Norwegian cancer survivors and the impact of traditional and complementary medicine use: the Tromsø Study 2015–2016

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