Wheat Alkylresorcinols Suppress High-Fat, High-Sucrose Diet-Induced Obesity and Glucose Intolerance by Increasing Insulin Sensitivity and Cholesterol Excretion in Male Mice

Abstract

These findings suggest that wheat alkylresorcinols increase glucose tolerance and insulin sensitivity by suppressing hepatic lipid accumulation and intestinal cholesterol absorption, which subsequently suppresses diet-induced obesity in mice.

Bamboo shoot fiber prevents obesity in mice by modulating the gut microbiota

“…Wheat fiber has long been known to be effective in controlling body weight and reducing cardiovascular and diabetes risks67819. Recent studies demonstrated that wheat fiber and phytochemicals isolated from wheat bran suppressed body weight gain in high-fat diet fed mice20. In agreement with these reports our results showed that insoluble fibers were more effective in suppressing high-fat diet induced obesity than soluble fibers.…”

“…This finding is consistent with the result from in vitro test showing that the bamboo shoot fiber has the highest oil-holding capacity compared with cellulose, wheat fiber, and soybean fiber (Supplementary Figure S8). Insoluble hydroxypropyl methylcellulose and wheat fiber were also reported to result in more fecal lipid excretion2022. Our results suggest that inclusion of bamboo shoot fiber resulted in the least metabolizable energy without affecting feeding behavior compared with other fibers.…”

“…Wheat fiber was shown to prevent obesity but with increased energy intake when supplemented to a high-fat diet in mice9. In many cases, energy intake was not correlated with fat accumulation92031. Although we did not measure food intake in all the nine groups, it is likely that factors other than food intake play important roles in the difference in controlling body weight among various types of fibers.…”

“…Several dietary fibers were reported to have prebiotic effects20212233. Chitin-glucan fiber improved host metabolic alterations induced by high-fat diet in mice through increased gram-positive bacteria from clostridial cluster XIVa including Roseburia 21.…”

“…The definition of dietary fiber has evolved in the last 30 years but the same basis remains, as carbohydrate polymers that are resistant to digestion and absorption in the human small intestine, whether they are natural or synthetic, soluble or insoluble, fermented or not fermented, viscous or non viscous19. Recent studies demonstrated that several fibers, including wheat bran-derived alkylresorcinols20, chitin-glucan fiber21, and hydroxypropyl methylcellulose22 suppressed body weight and improved host metabolic disorders in high-fat diet induced obese mice through counteracting gut dysbiosis. The common feature of these studies is that they investigated the effects of additional amount of a specific fiber in a high-fat diet, i.e.…”