Wheat dependent exercise induced anaphylaxis: is this an appropriate terminology?

Abstract

Specific IgE to romega-5-gliadin can provide supportive evidence for WDEIA without the need of a food-exercise challenge. The wheat-exercise association is not obvious in many patients, highlighting the need to consider WDEIA in the differential diagnosis of all patients presenting with idiopathic systemic reactions. The term anaphylaxis may be inappropriate and it is therefore worth considering an alternative terminology such as 'activity dependent wheat allergy' to describe this condition.

Wheat‐dependent exercise‐induced anaphylaxis

“…A prolonged time lag (32-62 months) to diagnosis is not uncommon [78]. A prolonged time lag (32-62 months) to diagnosis is not uncommon [78].…”

“…The precise diagnosis of WDEIA is extremely important, but there is a lack of awareness of WDEIA among patients as well as physicians. A prolonged time lag (32-62 months) to diagnosis is not uncommon [78]. WDEIA may be mistaken for other diseases such as acute urticaria, exercise-induced anaphylaxis, or idiopathic anaphylaxis, and a high index of clinical suspicion is required.…”

Wheat-dependent exercise-induced anaphylaxis: a retrospective case review from a tertiary hospital

“…Unfortunately, diagnostic delay is not uncommon15 and is likely related to lack of awareness of the condition among patients as well as doctors. This appeared to be the case in our series, as evidenced by most of the patients having a history suggestive of FDEIA prior to consultation at our hospital: most patients were previously diagnosed with just ‘anaphylaxis’.…”

Wheat-dependent exercise-induced anaphylaxis associated with a facial soap

“…We performed a radioallergosorbent test, and it was positive for wheat. We made a diagnosis of so-called, wheat-dependent exercise-induced anaphylaxis (WDEIA) 1. WDEIA is one of the most important clinical phenotypes of adult wheat allergy.…”