Wheel running decreases palatable diet preference in Sprague–Dawley rats

Moody, Laura; Liang, Jie; Choi, Pique; Moran, Timothy H.; Liang, Nu-Chu

doi:10.1016/j.physbeh.2015.03.019

Cited by 33 publications

(26 citation statements)

References 38 publications

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“…Results of experiment 1 replicated our previous results that wheel running induces reduced intake of a novel HF diet (29) and demonstrated that plasma corticosterone levels were significantly increased and positively correlated with wheel-running activity during the two-diet-choice feeding regimen. The results are consistent with our hypothesis that elevation of circulating corticosterone may be involved in wheel-runningassociated reduction in HF diet intake/preference.…”

Section: Discussionsupporting

confidence: 82%

“…Wheel running immediately reduces intake of and preference for a HF diet regardless of its familiarity (23,29). Results of experiment 1 replicated our previous results that wheel running induces reduced intake of a novel HF diet (29) and demonstrated that plasma corticosterone levels were significantly increased and positively correlated with wheel-running activity during the two-diet-choice feeding regimen.…”

Section: Discussionsupporting

confidence: 78%

“…In addition to the chow diet, the second Sed group received the 60% HF diet 2 h before the dark onset on the day of blood sampling (SedChoice). The inclusion of SedChow and SedChoice without WRChow as control groups was based on previous reports that wheel running increases corticosterone levels in a chow-fed condition (4,10) and that a limited amount of HF diet was consumed on the first day of wheel running in a chow vs. HF diet regimen (29). The experiments thus focused on the potential role of corticosterone in the reduction of HF diet intake.…”

Section: Experiments 1: Wheel Running-and Diet Choice-associated Cortimentioning

confidence: 99%

“…We have used this paradigm to demonstrate that wheel running reduces intake and preference to a previously preferred HF diet (23). When the exposure to the HF diet and wheel-running opportunity occurs simultaneously, the reduced HF diet preference can be so profound that the rats avoid the HF diet and consume only the chow diet (29). HF diet avoidance associated with wheel running is robust and lasted even when the rats are no longer running (29).…”

mentioning

confidence: 99%

“…When the exposure to the HF diet and wheel-running opportunity occurs simultaneously, the reduced HF diet preference can be so profound that the rats avoid the HF diet and consume only the chow diet (29). HF diet avoidance associated with wheel running is robust and lasted even when the rats are no longer running (29). The underlying mechanisms, however, remain obscure.…”

mentioning

confidence: 99%

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Corticosterone administration in drinking water decreases high-fat diet intake but not preference in male rats

Boersma

Tamashiro

Moran

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

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One of the mechanisms through which regular exercise contributes to weight maintenance could be by reducing intake and preference for high-fat (HF) diets. Indeed, we previously demonstrated that wheel-running rats robustly reduced HF diet intake and preference. The reduced HF diet preference by wheel running can be so profound that the rats consumed only the chow diet and completely avoided the HF diet. Because previous research indicates that exercise activates the hypothalamic-pituitary-adrenal axis and increases circulating levels of corticosterone, this study tested the hypothesis that elevation of circulating corticosterone is involved in wheel running-induced reduction in HF diet preference in rats.Experiment 1 measured plasma corticosterone levels under sedentary and wheel-running conditions in the two-diet-choice (high-carbohydrate chow vs. HF) feeding regimen. The results revealed that plasma corticosterone is significantly increased and positively correlated with the levels of running in wheel-running rats with two-diet choice.Experiments 2 and 3 determined whether elevated corticosterone without wheel running is sufficient to reduce HF diet intake and preference. Corticosterone was elevated by adding it to the drinking water. Compared with controls, corticosterone-drinking rats had reduced HF diet intake and body weight, but the HF diet preference between groups did not differ. The results of this study support a role for elevated corticosterone on the reduced HF diet intake during wheel running. The elevation of corticosterone alone, however, is not sufficient to produce a robust reduction in HF diet preference.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 78%

Section: Experiments 1: Wheel Running-and Diet Choice-associated Cortimentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Corticosterone administration in drinking water decreases high-fat diet intake but not preference in male rats

Boersma

Tamashiro

Moran

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

Self Cite

View full text Add to dashboard Cite

show abstract

The effects of scheduled running wheel access on binge-like eating behavior and its consequences

et al. 2018

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Voluntary exercise blocks Western diet-induced gene expression of the chemokines CXCL10 and CCL2 in the prefrontal cortex

Carlin

Grissom

Ying

et al. 2016

Brain, Behavior, and Immunity

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Obesity increases inflammation, both peripherally and centrally, and exercise can ameliorate some of the negative health outcomes associated with obesity. Within the brain, the effect of obesity on inflammation has been well characterized in the hypothalamus and hippocampus, but has been relatively understudied in other brain regions. The current study was designed to address two primary questions; (1) whether western diet (high fat/high sucrose) consumption would increase markers of inflammation in the prefrontal cortex and (2) whether concurrent voluntary wheel running would ameliorate any inflammation. Adult male mice were exposed to a western diet or a control diet for 8 weeks. Concurrently, half the animals were given running wheels in their home cages, while half did not have access to wheels. At the conclusion of the study, prefrontal cortex was removed and expression of 18 proinflammatory genes was assayed. Expression of a number of proinflammatory molecules was upregulated by consumption of the western diet. For two chemokines, chemokine (C-C motif) ligand 2 (CCL2) and C-X-C motif chemokine 10 (CXCL10), voluntary exercise blocked the increase in the expression of these genes. Cluster analysis confirmed that the majority of the tested genes were upregulated by western diet, and identified another small cluster of genes that were downregulated by either diet or exercise. These data identify a proinflammatory phenotype within the prefrontal cortex of mice fed a western diet, and indicate that chemokine induction can be blocked by voluntary exercise.

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Wheel running decreases palatable diet preference in Sprague–Dawley rats

Cited by 33 publications

References 38 publications

Corticosterone administration in drinking water decreases high-fat diet intake but not preference in male rats

Corticosterone administration in drinking water decreases high-fat diet intake but not preference in male rats

The effects of scheduled running wheel access on binge-like eating behavior and its consequences

Voluntary exercise blocks Western diet-induced gene expression of the chemokines CXCL10 and CCL2 in the prefrontal cortex

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