Wheel Running Simultaneously Induces CTA and Facilitates Feeding in Non-deprived Rats

A high‐fat diet prevents and reverses the development of activity‐based anorexia in rats

“…Several studies have investigated the role of conditioned taste aversion in the development of activity-based anorexia. [18][19][20][21] The conditions necessary for conditioned taste aversion to occur are present in activity-based anorexia experiments. 22 Rats are exposed to a conditioned stimulus (CS), which is the taste of the novel food eaten during the feeding period, and then to the unconditioned stimulus (US) of wheel running.…”

Pairings of a distinctive chamber with the aftereffect of wheel running produce conditioned place preference

“…Drugs that have a reinforcing effect such as amphetamine and morphine have been shown to produce simultaneously CTA and CPP (Reicher & Holman, 1977;Sherman et al, 1980). Some investigators (Lambert, 1993;Lett et al, , 1998a have hypothesized that the reward system activated by wheel running is the mesolimbic dopamine reward system (e.g. Vaccarino et al, 1989;Wise & Rompre , 1989).…”

“…However, pairings of a taste stimulus with 30 min of wheel running have been found to produce conditioned taste aversion (CTA) Lett et al, 1998a), suggesting that wheel running has an aversive effect. Although the conditions under which these two effects of wheel running have been observed are different, it seems likely that the same episode of wheel running would simultaneously support conditioning of an aversion to a taste stimulus that preceded it and a preference for a place stimulus that followed it.…”

“…Various investigators have hypothesized that the rewarding activation produced by wheel running mediates the suppression of feeding (Epling & Pierce, 1992;Lambert, 1993;Lett et al, , 1998a. There are at least two ways in which this might occur.…”

Postreinforcement Pause Duration Varies Within a Session and With a Variable Response Requirement but Not as a Function of Prior Revolutions

“…Previous research shows that rats develop an aversion to a flavor (Lett & Grant, 1996;Lett, Grant, & Gaborko, 1998;Salvy, Heth, Pierce, & Russell, 2004), food (Salvy, Pierce, Heth, & Russell, 2003), or place (Masaki & Nakajima, 2008) that occurs prior to an opportunity to run and a preference for a flavor (Hughes & Boakes, 2008) or place (Lett, Grant, Byrne, & Koh, 2000;, 2002Lett, Grant, Koh, & Smith, 2001) that immediately follows the termination of a period of running. Generalization of these effects to an experimental session might predict that the rats would show longer pauses at the beginning of a session and shorter pauses at the end.…”