Topicality. Today's drastic changes in the global market situation affect domestic economies, both developed and that are not. Under such influence, not only the structure of the economy changes, but also relationships. Moreover, the impact on the latter is more noticeable, which should be taken into account by governments, the system of resource distribution and, in general, the system of its regulation.The motivations for states to apply the policy of selective import substitution are due to the need to take into account and adapt to changes in the global market situation.The proposed author's vision and possible forecast of the state of the economy and those problems that may arise for the country and regions as a result of economic losses from military operations. The need for a selective approach to the regulation of commodity markets with the mandatory participation of state and regional management bodies and corporations is substantiated. The methodological essence of it is presented with the disclosure of regulatory mechanisms, functions and powers of the subjects of the regulatory system. The research is intended to determine and substantiate the directions of operational regulation, formed and formed in the post-war period of the economic system and its further development.Aim and tasks: development of an effective approach to regulating the state economy in the post-war period on the basis of selective import substitution.The tasks that were set before the research to achieve the goal are reduced to the following definitions:-general theoretical provisions of the theory of import substitution and the possibilities of their application in the post-war conditions of Ukraine;-peculiarities and principles of motivating motives for the application of import substitution policy in the post-war period;-effective approaches to introducing a selective policy of import substitution in the post-war period;-mechanisms and measures of implementation of import substitution policy.Research materials and methods are based on: data of the State Statistics Service of Ukraine, the World Bank, publications of scientific articles and mass media, historical experience, dynamic comparison, content analysis, grouping, classification, modeling, forecasting, etc.Research results of studies include:- definition (clarification) of the essence of the policy of selective import substitution;- justification of the need to combine two theories - import substitution and selective regulation;- determination of the motivations for the introduction of the policy of selective import substitution in the state in relation to the appropriate time and state of the economy of its strategic markets;- a methodical approach to the definition and selection of economic mechanisms that can and should implement the policy of selective import substitution in the country;- defined sectors of the national economy and markets to which targeted regulation should be applied in the first place;- the proposed method of determining a complex of mechanisms that can be applied in the implementation of the policy of selective import substitution and the selection of target tasks from it.Conclusion. The conclusions obtained during the research are summarized as follows:- the main task of the state in the post-crisis (post-war) period, by the way, as in all other transitional periods, is the preservation of resources (human, natural, infrastructural, energy, food, etc.);- therefore, the markets on which these resources circulate as goods must be under strict state control, and given that during a crisis, war, they suffer significantly and lose their assets, resources, they are subject to strict targeted regulation;- the most suitable and effective method of economic regulation of markets for post-crisis countries that have lost a significant part of their resources (including Ukraine) is the method of selective import substitution.