Informal caregivers are a critical, yet frequently unacknowledged part of the healthcare system. It is commonly presumed that providing assistive technology (AT) will decrease the burden of their care provision; however, no review has evaluated the evidence behind this assumption. Therefore, a systematic reviews was undertaken to evaluate evidence of the impact of AT use by care-recipients on their informal caregivers. Data Sources included Embase, Medline, Cumulative Index to Nursing and Allied Health Literature, Web of Science, PsychINFO, and active researchers in this area. Twenty-two studies met the specified inclusion criteria. Collectively, the findings suggest that AT use helps caregivers by diminishing some of the physical and emotional effort entailed in supporting individuals with a disability. However, confidence in this causal connection is limited because of the relatively weak study designs that were used. This undermines our understanding of the impacts of AT use on users’ informal caregivers.