Wheezes, blisters, bumps and runs: multisystem manifestations of a Crohn's disease flare-up

Bhat, Mamatha; Dawson, David J.

doi:10.1503/cmaj.070290

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…3,4 In adults, edematous cobblestone mucosa has been reported as a manifestation of pulmonary complications in patients with inflammatory bowel disease; in such cases, diffuse edema mucosal protrusions lead to a narrow airway and respiratory distress. 7,8 This situation is similar to what we observed in our present case.…”

Section: Discussionsupporting

confidence: 92%

A neonate with tracheobronchial cobblestone mucosa presenting with acute severe hypercapnia

Liu¹,

Hu³

2019

Turk J Pediatr

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Here, we describe the case of a neonate suffering from respiratory distress complicated by pulmonary hemorrhage shortly after birth. The neonate experienced repeated dyspnea and acute severe hypercapnia (160-100 mmHg) that began on the 7th day after birth during invasive mechanical ventilation. Rescue high frequency oscillatory ventilation played a key role in maintaining gas exchange during these episodes. Subsequent bronchoscopy revealed tracheobronchial edematous mucosa with a cobblestone pattern, which we believe is the first report of this condition in neonates. Protrusion of the diffuse edematous mucosa led to airway stenosis and respiratory distress. Lesions of the tracheal mucosa should therefore be considered as one potential cause of neonatal respiratory distress.

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Section: Discussionsupporting

confidence: 92%

A neonate with tracheobronchial cobblestone mucosa presenting with acute severe hypercapnia

Liu¹,

Hu³

2019

Turk J Pediatr

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“…4 Of these previous cases of PG with pulmonary involvement, only 16 had lung biopsies performed. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Histopathologic findings from the lung biopsies showed a spectrum of changes, including palisading granulomas around foci of necrosis, mixed inflammatory infiltration (ie, various combinations of lymphocytes, monocytes, histiocytes, and neutrophils), multifocal neutrophilic abscesses, intra-alveolar neutrophilic infiltrate, focal vasculitis, and fibrosis or necrosis of lung parenchyma. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] In the case described herein, the core needle biopsy of the lung nodule also revealed similar findings, which included parenchymal necrosis, mixed inflammation, and focal vasculitis.…”

Section: Discussionmentioning

confidence: 99%

Fatal Case of Vulvar Pyoderma Gangrenosum with Pulmonary Involvement: Case Presentation and Literature Review

et al. 2014

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A thorough review of the literature revealed 33 cases of PG with pulmonary involvement, with only 4 involving the perigenital region. We report the second case of a female with vulvar PG and pulmonary involvement. In contrast to the first case described, our patient did not respond to systemic therapy, and, ultimately, her disease was fatal. It is hoped that with continued documentation of this rare and potentially lethal presentation of PG, physicians will determine more effective treatments.

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“…Since that report there have been small series but mostly isolated case reports. A spectrum of pulmonary involvement has been described, including: 1) airway disease (tracheal [4] and tracheobronchial [5] stenosis, tracheobronchitis [6], bronchitis [3], bronchiectasis [7], bronchiolitis [8] and asthma [9]); 2) interstitial lung disease (granulomatous alveolitis [10], bronchiolitis obliterans with organising pneumonia [11], interstitial fibrosis [12] and lung infiltrates with peripheral eosinophilia [13]); and 3) serositis (pleural thickening [12] and pleuropericarditis [13]). …”

Section: Discussionmentioning

confidence: 99%

Pulmonary necrobiotic nodules: a rare extraintestinal manifestation of Crohn's disease

Warwick¹,

Leecy²,

Silverstone³

et al. 2009

Eur Respir Rev

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The present article reports the case of a 22-yr-old female with new onset Crohn's colitis, anterior uveitis and multiple pulmonary nodules which, on histological examination, were necrobiotic nodules. This is a rare but recognised pulmonary extraintestinal manifestation of Crohn's disease and only the fourth reported case. The present case report is followed by a brief review of the relevant literature.

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Wheezes, blisters, bumps and runs: multisystem manifestations of a Crohn's disease flare-up

Cited by 7 publications

References 6 publications

A neonate with tracheobronchial cobblestone mucosa presenting with acute severe hypercapnia

A neonate with tracheobronchial cobblestone mucosa presenting with acute severe hypercapnia

Fatal Case of Vulvar Pyoderma Gangrenosum with Pulmonary Involvement: Case Presentation and Literature Review

Pulmonary necrobiotic nodules: a rare extraintestinal manifestation of Crohn's disease

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