Wheezing, asthma, hay fever, and atopic eczema in relation to maternal occupations in pregnancy

Magnusson, Linda L; Wennborg, Helena; Bonde, Jens Peter; Olsen, Jørn

doi:10.1136/oem.2005.024422

Cited by 38 publications

(59 citation statements)

References 33 publications

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“…A case of baker's asthma in a 2-yr-old exposed at his grandfather's bakery demonstrates that children can become sensitised to occupational sensitisers and develop asthma [12]. A Danish birth cohort study reported some maternal jobs during the antenatal period to be associated with an increased risk of wheeze, asthma and allergic diseases in children aged 14-18 yrs [6]. Some of the highlighted occupations (bakers, pastry cooks, confectionary makers and dental assistants) entail exposure to latex/biocides and flour.…”

Section: Discussionmentioning

confidence: 99%

“…This hypothesis was tested in the Avon Longitudinal Study of Parents and Children (ALSPAC), which prospectively collected data on parental occupation and childhood respiratory symptoms/asthma. Certain maternal occupations during pregnancy have been reported to increase the risk of asthma and allergic disease in older children [6]. The ALSPAC cohort permitted the investigation of possible effects of maternal antenatal and also post-natal occupation on the likelihood of childhood respiratory symptoms and asthma.…”

mentioning

confidence: 99%

“…cases of asthma caused by exposure to toluene diisocyanate in people not directly working with this chemical but working in the vicinity of factories using toluene diisocyanate [4]. Para-occupational exposure of children via parent(s) to asbestos, pesticides and organic solvents with health sequelae has been described [5][6][7][8]. There is also evidence that occupational allergens can be transported home, presumably on contaminated clothing and skin, with subsequent atopic sensitisation of other household residents [9][10][11][12].…”

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confidence: 99%

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Parental occupation is a risk factor for childhood wheeze and asthma

Tagiyeva

Devereux²,

Semple³

et al. 2009

Eur Respir J

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The present birth cohort study investigated whether or not childhood wheeze and asthma are associated with parental exposure to occupational sensitisers that cause asthma.Parental occupation, from the Avon Longitudinal Study of Parents and Children (ALSPAC), was related to wheeze, asthma, ventilatory function, airway responsiveness and atopic sensitisation in children aged 0-102 months.Occupation was recorded for 11,193 mothers and 9,473 fathers antenatally, and for 4,631 mothers and 5,315 fathers post-natally. Childhood respiratory outcomes were not associated with parental occupational exposure to diisocyanates, glues/resins, dyes, animal dust, solder, enzymes and wood dust. Maternal post-natal occupational exposure to latex and/or biocides/fungicides increased the likelihood of childhood wheeze and asthma. High levels of latex or biocide/fungicide exposure were associated with an OR (95% CI) of 1.26 (1.07-1.50) and 1.22 (1.02-2.05), respectively, for wheezing up to 81 months. Combined maternal latex and biocide/fungicide exposure increased the likelihood of childhood wheeze (1.22 (1.03-1.43)) and asthma. High paternal occupational flour dust exposure was associated with an increased likelihood of wheeze after 30 months (2.31 (1.05-5.10)) and asthma by 91 months (3.23 (1.34-7.79)).Maternal occupational exposure to latex and/or biocides and paternal exposure to flour dust increases the risk of childhood asthma. Further studies in this area are justified.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Parental occupation is a risk factor for childhood wheeze and asthma

Tagiyeva

Devereux²,

Semple³

et al. 2009

Eur Respir J

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“…One previous study found an association between maternal exposure during pregnancy to latex and biocides childhood asthma (Tagiyeva et al, 2010). In addition, many hospital workers have shift work, and a previous study found that mothers shift work during pregnancy was a risk factor for asthma in the offspring (Magnusson et al 2006). The other maternal occupations associated with an increased risk of childhood asthma or rhinitis in our study (salesperson, teacher, office worker) did not have any obvious exposure to chemicals or allergens.…”

Section: Or(95%ci) Or(95%ci) Or(95%ci) Or(95%ci) Or(95%ci) Or(95%cimentioning

confidence: 41%

“…One Danish study found that if the mother had worked as baker, dental assistant, electric/electronic assembler, sewer/embroider or bookbinder during pregnancy, the offspring had more atopic diseases. Moreover, there was an increased risk of asthma among the children if the mothers had shift work during pregnancy (Magnusson et al, 2006). Another study from Denmark found that maternal occupational exposure to low molecular weight compounds (LMW) known to cause occupational asthma (asthmogens) during pregnancy was associated with a borderline significantly increase of asthma in 7-year-old children (Christensen et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Associations between parental health, early life factors and asthma, rhinitis and eczema among pre-school children in Chongqing, China

Wang

Li²,

Yu³

et al. 2016

GJHS

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Purpose: To study associations between parental factors and children's asthma, rhinitis and eczema. Methods:Parents of 3-6 years old children in Chongqing, China answered a questionnaire on parental history of asthma/allergies, parental symptoms and children's asthma, rhinitis and eczema. Associations were analyzed by multiple logistic regression. Results:Among 4250 children (response rate: 74.5%), 8.4% had doctor-diagnosed asthma (DD asthma); 6.2% doctor-diagnosed allergic rhinitis (DD rhinitis); 20.4% wheeze; 19.4% cough; 37.9% rhinitis and 13.6% eczema. Among reporting parents (females 70.4%, males 29.6%), 16.2% were smokers; 47.4% reported rhinitis; 54.2% cough; 47.8% skin symptoms; 70.5% fatigue and 48.7% headache.Parental asthma/allergy was associated with children's DD asthma (OR=3.64) and DD rhinitis (OR=4.23). The associations were stronger for paternal asthma/allergy. Rural children had less DD rhinitis and current rhinitis. Children of mothers who were salespersons during pregnancy had more rhinitis (OR=1.49), children of teachers had more DD rhinitis (OR=2.09) and cough (OR=1.66), children of office workers had more DD rhinitis (OR=2.04) and children of mothers working in hospitals had more DD asthma (OR=2.47). Parental current symptoms were associated with wheeze, cough, rhinitis and eczema among the children with ORs ranging from 1.37 to 2.28 (all p<0.001). Conclusions:Parental asthma/allergy can be a risk factor for asthma or allergy, especially paternal asthma/allergy. Growing up in rural areas can be beneficial for rhinitis. Mother's occupation during pregnancy may influence children's asthma and rhinitis. In questionnaires studies on children's asthma or allergies, the reporting parent's gender and current medical symptoms may influence the results.Keywords: Pre-school children, asthma, rhinitis, eczema, home environment, rural childhood, occupation, validation, fatigue, headache IntroductionChildren's asthma and allergies has increased globally (Chen, 2003;Asher et al., 2006). The international Study of Asthma and Allergies in Childhood (ISAAC) has compared asthma and allergy between different countries (The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee, 1998), and analyzed associations with the home environment (Brunekreef et al., 2012). A recent review suggested that the rise in the prevalence of allergic disorders globally is associated with the whole civilizational progress, which is a complex interplay between immune response, invading pathogens, diversity of environmental factors and genetic background (Rutkowski et al., 2014).Parental factors can influence the prevalence of asthma, rhinitis and eczema in their children in different ways.

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