Wheezing in childhood: incidence, longitudinal patterns and factors predicting persistence

Matricardi, P. M.; Illi, Sabina; Grüber, Christoph; Keil, Thomas; Nickel, Renate; Wahn, Ulrich; Lau, Susanne

doi:10.1183/09031936.00066307

Cited by 161 publications

(173 citation statements)

References 27 publications

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“…SCOTT et al [1] have commented, in the light of outcomes of their ''Isle of Wight Birth Cohort study'' (IoWBC) [2,3], on our findings on the risk factors for asthma in the Multicentre Allergy Study (MAS) birth cohort study [4]. We agree that the two studies lead to similar conclusions in regard to early origins of persistent wheezing, heterogeneity of childhood wheezing and the relevance of an atopic background.…”

supporting

confidence: 63%

Predicting persistence of wheezing: one algorithm does not fit all

Matricardi¹,

Illi²,

Keil³

et al. 2010

Eur Respir J

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Indeed, the current classification moves to the right direction by adopting a clinically meaningful way of thinking and avoiding unnecessary pathophysiological implications; PH owing to left heart disease (Group 2) and chronic thromboembolism (Group 4) are good examples. In this context, sarcoidosis, PLCH and LAM (Group 5.2) represent disorders that, according to the current evidence, are associated with PH mainly due to lung involvement and, therefore, we propose their inclusion in the third category (PH owing to lung disease and/or hypoxia) in any future classification scheme.

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supporting

confidence: 63%

Predicting persistence of wheezing: one algorithm does not fit all

Matricardi¹,

Illi²,

Keil³

et al. 2010

Eur Respir J

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“…Nosso estudo utilizou como critério de gravidade "epidemiológica" da asma, as respostas de maior gravidade referentes aos sintomas de asma disponíveis no questionário ISAAC, ou seja, o número máximo de exacerbações no ano (mais de 12) e de despertares noturnos por semana (mais de 1), bem como a dificuldade de pronunciar palavras completas nas crises. 17 , como mostrado em alguns estudos longitudinais 18,19 . Outra explicação possível para esse achado é ter ocorrido uma variação na percepção do sibilo, o que pode ocorrer em casos de doença mais leve 20 ou tratar-se de formas atípicas de asma como a variante tosse, que constitui um subgrupo de asmáticos que não manifestam a sibilância 21,22 .…”

Section: Discussionunclassified

Distribution of severity of asthma in childhood

Simões¹,

Cunha²,

Barreto³

et al. 2010

J Pediatr (Rio J)

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Objective: To estimate the distribution of asthma severity in a population-based sample of children from Salvador, Brazil.Methods: An epidemiologically oriented questionnaire (International Study of Asthma and Allergies in Childhood, ISAAC) and a questionnaire based on criteria used in clinical practice (The Global Initiative for Asthma, GINA) were administered simultaneously to 417 children aged 5 to 12 years who reported symptoms of asthma in the past 12 months. According to the ISAAC instrument, children were classified into severe and non-severe asthma, whereas GINA clinical criteria produced four categories of severity: intermittent, mild persistent, moderate persistent and severe asthma.Results: Ninety children reported symptoms indicative of severity according to the ISAAC questionnaire. According to GINA criteria, 143 children had intermittent asthma, 160 mild persistent, 51 moderate and 43 severe asthma. Agreement between the two instruments was 81.3% (kappa = 0.5). Conclusions:Most asthmatic children in the Salvador urban area have persistent asthma. Agreement between epidemiological and clinical classifications of asthma severity was satisfactory.J Pediatr (Rio J). 2010;86(5):417-423: Asthma, severity, questionnaire, child.

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“…Thirdly, the date of each episode could be precisely established, allowing for a high-resolution month-to-month analysis. Fourthly, the sample size is relatively large, as compared to questionnaire-based prospective birth cohort studies, and the rate of losses is quite small [2,3,13,14,[18][19][20].…”

Section: Limitations and Strengthsmentioning

confidence: 99%

Early patterns of wheezing in asthmatic and nonasthmatic children

Garcinuño¹,

Gandarillas²

2013

Eur Respir J

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The aim of this study was to describe the time patterns of wheezing in both asthmatic and nonasthmatic children during the first 36 months of life, and to determine whether there are asthma-related breakpoints in the incidence of wheezing.Data from a historical cohort of children followed from birth to 6 years (SLAM cohort) were used. Wheezing episodes until 36 months and asthma at 6 years were both recorded by a doctor. Monthly mean incidence rate of wheezing and rate ratio were calculated. Joinpoint regression models were built to identify breakpoints in the risk of wheeze.Complete information was available for 3739 children. Wheezing in the first 36 months was more frequent in asthmatic than in nonasthmatic children (rate ratio 2.62, 95% CI 1.81-3.78). Differences were appreciable within the first months and increased steadily thereafter because of a persistently high rate in asthmatic children. No breakpoint in the rate ratio could be identified. Asthmatic children exhibited a onephase curve of incidence and nonasthmatic children exhibited a two-phase curve. However, children with allergic asthma also displayed a two-phase curve.There is no identifiable breakpoint during the first 36 months of life at which the incidence of wheezing in asthmatic children begins to stand out. @ERSpublications Increased wheezing in asthmatic children from birth; different progression patterns for allergic and nonallergic asthma

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Wheezing in childhood: incidence, longitudinal patterns and factors predicting persistence

Cited by 161 publications

References 27 publications

Predicting persistence of wheezing: one algorithm does not fit all

Predicting persistence of wheezing: one algorithm does not fit all

Distribution of severity of asthma in childhood

Early patterns of wheezing in asthmatic and nonasthmatic children

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