Wheezing preschool children with early‐onset asthma reveal a specific metabolomic profile

Carraro, Silvia; Bozzetto, Sara; Giordano, Giuseppe; Mazloum, Dania El; Stocchero, Matteo; Pirillo, Paola; Zanconato, Stefania; Baraldi, Eugenio

doi:10.1111/pai.12879

Cited by 45 publications

(66 citation statements)

References 24 publications

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“…The urine samples were analyzed at the Mass Spectrometry Laboratory, Department of Women's and Children's Health, Padova University Hospital, Fondazione Istituto di Ricerca Pediatrica Città della Speranza. The sample preparation method and the chromatographic and mass spectrometry conditions were as described in a previous work [9,11] and elsewhere in this article (Supplementary Materials). Briefly, the metabolic profile of the urine was acquired using a Waters Acquity Ultra-Performance Liquid Chromatography system coupled to a Waters Q-TOF Synapt G2 mass spectrometer (Waters, Milford, MA).…”

Section: Metabolomic Analysismentioning

confidence: 99%

“…Recently, an approach called "metabolomics" [6,7] has revealed the potential to identify the metabolic features of certain conditions, differentiating between phenotypes of the same disease and enabling a better characterization of the pathological mechanisms involved. Metabolomic studies are typically performed on biofluids, and urine samples are among the most often used in medical research, especially studies of children, because they can be collected using simple, noninvasive techniques [8][9][10].…”

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confidence: 99%

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Metabolomic Profiling of Infants With Recurrent Wheezing After Bronchiolitis

Barlotta

Pirillo

Stocchero

et al. 2018

The Journal of Infectious Diseases

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Background. Bronchiolitis is associated with a greater risk of developing recurrent wheezing, but with currently available tools, it is impossible to know which infants with bronchiolitis will develop this condition. This preliminary prospective study aimed to assess whether urine metabolomic analysis can be used to identify children with bronchiolitis who are at risk of developing recurrent wheezing.Methods. Fifty-two infants <1 year old treated in the emergency department at University Hospital of Padova for acute bronchiolitis were enrolled (77% tested positive for respiratory syncytial virus [RSV]). Follow-up visits were conducted for 2 years after the episode of bronchiolitis. Untargeted metabolomic analyses based on mass spectrometry were performed on urine samples collected from infants with acute bronchiolitis. Data modeling was based on univariate and multivariate data analyses.Results. We distinguished children with and those without postbronchiolitis recurrent wheeze, defined as ≥3 episodes of physician-diagnosed wheezing. Pathway overrepresentation analysis pointed to a major involvement of the citric acid cycle (P < .001) and some amino acids (lysine, cysteine, and methionine; P ≤ .015) in differentiating between these 2 groups of children.Conclusion. This is the first study showing that metabolomic profiling of urine specimens from infants with bronchiolitis can be used to identify children at increased risk of developing recurrent wheezing.

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Section: Metabolomic Analysismentioning

confidence: 99%

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confidence: 99%

Metabolomic Profiling of Infants With Recurrent Wheezing After Bronchiolitis

Barlotta

Pirillo

Stocchero

et al. 2018

The Journal of Infectious Diseases

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“…56 Wheezing preschool children have a characteristic metabolic urinary profile that can be used to predict if they will develop earlyonset asthma after a 3-year follow-up. 57 Dimethylamine and allantoin are gut microbial-derived metabolites that have been associated with asthma development in early childhood and are potential prognostic markers of asthma. 58 A comprehensive systematic review and meta-analysis has recently reviewed bronchial hyperresponsiveness (BHR) in preterm-born subjects.…”

Section: Pred Ic Ti On and Pre Venti On Of Allerg I C D Is E A S Ementioning

confidence: 99%

Highlights and recent developments in airway diseases in EAACI journals (2018)

Bousquet

Akdiş

Grattan

et al. 2019

Allergy

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The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Pediatric Allergy and Immunology, and Clinical and Translational Allergy. EAACI's major goals include supporting the promotion of health, in which the prevention of allergy and asthma plays a critical role, and disseminating the knowledge of allergic disease to all stakeholders. In 2018, the remarkable progress in the identification of basic mechanisms of allergic and respiratory diseases as well as the translation of these findings into clinical practice were observed. Last year's highlights include publication of EAACI guidelines for allergen immunotherapy, many EAACI Position Papers covering important aspects for the specialty, better understanding of molecular and cellular mechanisms, identification of biomarkers for disease prediction and progress monitoring, novel prevention and intervention studies, elucidation of mechanisms of multimorbidities, introduction of new drugs to the clinics, recently completed phase three clinical studies, and publication of a large number of allergen immunotherapy studies and meta‐analyses.

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“…The role of high levels of metabolites such as butyrate for protection of allergy has been well characterized earlier in cohorts of farming children . On the other hand, various studies published recently in this journal have linked specific gut microbiota patterns with allergies . Also, indirect interventions, such as early‐life antibiotic use and its impact on the gut microbiome, are known to influence the development of allergy .…”

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confidence: 99%