PurposeThis article reports the results from a panel discussion held at the 2019 European Conference on Information Systems (ECIS) on the use of technology-based autonomous agents in collaborative work.Design/methodology/approachThe panelists (Drs Izak Benbasat, Paul Benjamin Lowry, Stefan Morana, and Stefan Seidel) presented ideas related to affective and cognitive implications of using autonomous technology-based agents in terms of (1) emotional connection with these agents, (2) decision-making, and (3) knowledge and learning in settings with autonomous agents. These ideas provided the basis for a moderated panel discussion (the moderators were Drs Isabella Seeber and Lena Waizenegger), during which the initial position statements were elaborated on and additional issues were raised.FindingsThrough the discussion, a set of additional issues were identified. These issues related to (1) the design of autonomous technology-based agents in terms of human–machine workplace configurations, as well as transparency and explainability, and (2) the unintended consequences of using autonomous technology-based agents in terms of de-evolution of social interaction, prioritization of machine teammates, psychological health, and biased algorithms.Originality/valueKey issues related to the affective and cognitive implications of using autonomous technology-based agents, design issues, and unintended consequences highlight key contemporary research challenges that allow researchers in this area to leverage compelling questions that can guide further research in this field.