When a minor head injury results in enduring symptoms: a prospective investigation of risk factors for postconcussional syndrome after mild traumatic brain injury

Hou, Ruihua; Moss‐Morris, Rona; Peveler, Robert; Mogg, Karin; Bradley, Brendan P.; Belli, Antonio

doi:10.1136/jnnp-2011-300767

Cited by 330 publications

(287 citation statements)

References 46 publications

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“…38,[52][53][54][55][56][57][58][59] Using the methodology reported by McCauley and colleagues, 53 participants were queried regarding current involvement in, or anticipation of future, injury-related litigation or receipt of compensation. Of the mTBI group, 9.0% reported involvement in or planning of litigation compared with 6.3% of the OI group, which was not significantly different (Fisher exact test, p = 0.75), and 4.4% of the mTBI group reported receiving some form of injury-related compensation compared with 4.7% of the OI group, which was not significantly different (Fisher exact test, p = 1.0).…”

Section: Sample Characteristicsmentioning

confidence: 99%

Patterns of Early Emotional and Neuropsychological Sequelae after Mild Traumatic Brain Injury

McCauley

Wilde

Barnes

et al. 2014

Journal of Neurotrauma

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Although mild traumatic brain injury (mTBI) is now recognized as a major health issue, there have been relatively few studies of its acute effects. Previous studies of mTBI assessed at 1 week or less post-injury have produced inconsistent results, spanning reports of no ill effects to findings of robust dysfunction. These gross disparities reflect study differences such as the criteria for mTBI diagnosis and selection of comparison groups. In consideration of these issues, this study investigated outcome in the first 96 hours after injury in adolescents and adults ages 12-30 years with mTBI (n = 73) compared with orthopedically injured (OI, n = 65) and typically developing controls (TDC, n = 40). The mTBI group reported significantly greater general psychological distress, post-concussion symptom severity, and post-traumatic stress severity than OI (all p < 0.0001) and TDC (all p < 0.0001); the OI and TDC groups responded similarly on these variables. There was a significant Group · Age interaction on the Total score ( p < 0.009), and the Cognitive ( p = 0.01) and Somatic ( p < 0.032) subscales of the Rivermead Post Concussion Symptoms Questionnaire where increasing symptom severity was associated with increasing age in the mTBI group. On neuropsychological assessment, the mTBI group performed significantly more poorly compared with OI for Verbal Selective Reminding Test (delayed recall, p = 0.0003) and SymbolDigit Modalities Test (SDMT written p = 0.03; oral, p = 0.001). The TDC group more robustly outperformed the mTBI group on these measures and also on the Brief Visuospatial Memory Test (delayed recall, p < 0.04), Letter Fluency ( p < 0.02), and Category Switching ( p < 0.04). The TDC group outperformed the OI group on SDMT and Letter Fluency. These findings are consistent with previous reports of acute deficits in episodic memory and processing speed acutely after mTBI. Notably, however, these data also demonstrate the challenges of comparison group selection because differences were also found between the TDC and OI groups.

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Section: Sample Characteristicsmentioning

confidence: 99%

Patterns of Early Emotional and Neuropsychological Sequelae after Mild Traumatic Brain Injury

McCauley

Wilde

Barnes

et al. 2014

Journal of Neurotrauma

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“…There is a controversy about persisting effects of a mild brain injury. Psychological factors have been associated to worse outcome report [27], while metaanalyses have not been able to find residual cognitive impairment [9]. Still, while most return to normal levels at neuropsychological assessment within one year, fifty percent report three or more posttraumatic symptoms [28].…”

Section: Discussionmentioning

confidence: 99%

The relationship between thyroid hormone levels and cognitive functions in Graves’ disease might be influenced by a history of mild traumatic brain injury

Möller¹,

Bartfai²,

Rådestad³

et al. 2017

Brain Nerves

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“…This not only has substantial financial consequences for the Government and taxpayers but also could increase iatrogenesis because patients may come to believe that they have been put in particular treatments and given certain disability ratings because they truly do have many problems related to their TBI. Beliefs regarding mild TBI have been shown to be related to return to work, functional capacity, and postconcussive symptom report [28][29][30].…”

Section: Symptom Validity Assessmentmentioning

confidence: 99%

Utility of the Validity-10 scale across the recovery trajectory following traumatic brain injury

Lange¹,

Bailie

Kennedy

et al. 2016

J Rehabil Res Dev

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Abstract-The Validity-10 scale was recently developed to screen for symptom exaggeration in patients following traumatic brain injury (TBI). However, it has only been validated on patients with TBI largely in the chronic phase of recovery. The influence of time since injury on the Validity-10 scale was investigated in 2,661 male servicemembers with TBI presenting to six U.S. Defense and Veterans Brain Injury Centers. Participants completed the Neurobehavioral Symptom Inventory (NSI). The Validity-10 scale and NSI total score were both weakly statistically significantly (1) positively correlated with time since injury, (2) negatively correlated with bodily injury severity, and (3) higher in participants undergoing medical board evaluations than in participants who returned to duty or were still hospitalized. Participants were statistically more likely to screen positive for possible symptom exaggeration on the Validity-10 scale as time since injury increased. However, the Validity-10 scale was only weakly related to time since injury, TBI severity, bodily injury severity, disposition, age, and return to duty status. That false positives are not increased in the acute phase of recovery and that the Validity-10 scale is not strongly related to clinical factors support the use of the Validity-10 scale in the acute recovery phase and across the TBI recovery trajectory.

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When a minor head injury results in enduring symptoms: a prospective investigation of risk factors for postconcussional syndrome after mild traumatic brain injury

Cited by 330 publications

References 46 publications

Patterns of Early Emotional and Neuropsychological Sequelae after Mild Traumatic Brain Injury

Patterns of Early Emotional and Neuropsychological Sequelae after Mild Traumatic Brain Injury

The relationship between thyroid hormone levels and cognitive functions in Graves’ disease might be influenced by a history of mild traumatic brain injury

Utility of the Validity-10 scale across the recovery trajectory following traumatic brain injury

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