When bottom-up meets top-down

Shtein, Zvi; Shoseyov, Oded

doi:10.1073/pnas.1619392114

Cited by 18 publications

(11 citation statements)

References 13 publications

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“…4 Silk fibroin (SF), a proteinaceous biopolymer spun by the domesticated silkworm Bombyx mori, is a candidate biomaterial for tissue engineering applications. 5 SF-derived materials have been tested in small and large animals; some products have entered clinical trials, and a few have reached the market. 6 SF can adopt a native (NSF) or a regenerated (RSF) state.…”

Section: Introductionmentioning

confidence: 99%

Strategies for Tuning the Biodegradation of Silk Fibroin-Based Materials for Tissue Engineering Applications

Diane

Yang

Long

et al. 2020

ACS Biomater. Sci. Eng.

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The remarkable features of silk fibroin (SF) from the silkworm (Bombyx mori) have fueled its application as a candidate biomaterial for tissue regeneration and repair. For an ideal scaffold, the rate of degradation should be synchronized to match the rate of new tissue formation, and tuning this rate is essential, as diverse tissues differ in terms of regeneration period. In this Review, we discuss the factors influencing the degradability of SF, which can vary from days to several months, depending on the state of the raw material, the scaffold preparation process, morphological features, and host factors. This knowledge facilitates strategies for tuning the SF degradation rate, including manipulation of molecular weight, crystalline level, and crosslinking degree. Since these strategies have a great influence on the mechanical properties, the superiority of SF has to be sacrificed to satisfy the requirements for degradation rate. We further explore additional strategies, including the incorporation of degradation-promoting supplements such as blending with another polymer (e.g., gelatin) and the incorporation of enzyme-sensitive peptides. The information in this Review will likely aid scientists working with SF materials for the regeneration of diverse tissues.

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Section: Introductionmentioning

confidence: 99%

Strategies for Tuning the Biodegradation of Silk Fibroin-Based Materials for Tissue Engineering Applications

Diane

Yang

Long

et al. 2020

ACS Biomater. Sci. Eng.

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“…[ 47 ] In tissue engineering, if the hierarchy of biological tissue is to be fabricated, the signaling molecules, i.e., biomaterials with or without synthetic materials, must be incorporated through biofabrication to form a well‐defined, biodegradable, porous, polymeric scaffold to induce desired cell responses from the seeded cells, leading to engineered tissues and organs. [ 48,49 ] Scaffolds play a vital role in this approach as they provide support for cell adhesion, and the cells proliferate, differentiate, and grow to form new tissues or organs. Ideally, scaffolds should possess a specific pore size that allows cells to spread, be biologically degradable and compatible, and have mechanical features.…”

Section: Hierarchical Tissuesmentioning

confidence: 99%

Recent Advances in Regenerative Tissue Fabrication: Tools, Materials, and Microenvironment in Hierarchical Aspects

Ratri

Brilian

Setiawati

et al. 2021

Advanced NanoBiomed Research

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As part of regenerative medicine, artificial, hierarchical tissue engineering is a favorable approach to satisfy the needs of patients for new tissues and organs to replace those with defects caused by age, disease, or trauma or to correct congenital disabilities. However, the application of tissue engineering faces critical issues, such as the biocompatibility of the fabricated tissues and organs, the scaffolding, the complex biomechanical processes within cells, and the regulation of cell biology. Although fabrication strategies, including the traditional bioprinting, photolithography, and organ‐on‐a‐chip methods, as well as combinations of fabrication processes, face many challenges, they are methods that can be used in hierarchical tissue engineering. The strategic approach to synthetic, hierarchical tissue engineering is to use a combination of several technologies incorporating material science, cell biology, additive manufacturing (AM), on‐a‐chip strategies, and biomechanics. Herein, in a review, the current materials and biofabrication strategies of various artificial hierarchical tissues are discussed based on the level of tissue complexity from nano to macrosize and the adaptive interactions between cells and the scaffolding surrounding the incorporated cells.

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“…The loose, hierarchical classification methods we use here divide synthetic sorbents in two: they can be assembled from either a "bottom-up" synthesis from raw, unstructured chemical precursors or "top-down" synthesis, which uses a previously existing material's porous structure as a template for the new sorbent. 31 The latter is a popular method throughout the recent literature because the method exploits the recognizable elastic mechanical properties of readily obtained household/industrial sponges and applies an often nanoscopic surface layer to coat the coarse and fine voids with a nonpolar layer giving desirable oleophilic properties. 32 The sponges produced by this top-down method are demonstrably easy to use, can be reused/recycled with ease and the true cost of their synthesis is the chemical application of the surface layer.…”

Section: Current Sorbent Materialsmentioning

confidence: 99%

Scaling sorbent materials for real oil-sorbing applications and environmental disasters

Patalano

Villalobos

Pena

et al. 2019

MRS Energy & Sustainability

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There are few feasible options for sorbents, which can be quickly manufactured and deployed in the event of a major oil spill and so every oil spill is an ecological disaster. This paper aims to provide an understanding of what a realistic, full-scale crude oil spill solution would look like based on the performance of the best sorbents currently available, their costs, and their advantages.Adsorbent materials or “sorbents” described here have been a recent target for research toward applications in environmental cleanup, remediation, and hazardous material containment. These materials contain many compositions, syntheses, and practical manufacturing parameters that make most of them practically and logistically unfit to tackle quantities much larger than a single barrel of oil. Different properties of crude oil and nonpolar materials, such as their viscosity, density, and weathering, can also make these materials seem attractive on a lab scale but underperform in field testing and in practical applications. This review addresses the challenges, advantages, and disadvantages of different technical applications of the superior sorbent materials and material types in the literature. In addition, we discuss the different costs and manufacturing challenges of sorbent materials in real oil spills and what a feasible containment sorbent material might look like.

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When bottom-up meets top-down

Cited by 18 publications

References 13 publications

Strategies for Tuning the Biodegradation of Silk Fibroin-Based Materials for Tissue Engineering Applications

Strategies for Tuning the Biodegradation of Silk Fibroin-Based Materials for Tissue Engineering Applications

Recent Advances in Regenerative Tissue Fabrication: Tools, Materials, and Microenvironment in Hierarchical Aspects

Scaling sorbent materials for real oil-sorbing applications and environmental disasters

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