The present-day tectonic setting of the Western Mediterranean region, from the Pyrénées to the Betics and from the Alps to the Atlas, results from a complex 3-D geodynamic evolution involving the interactions between the Africa, Eurasia and Iberia plates and asthenospheric mantle dynamics underneath. In this paper, we review the main tectonic events recorded in this region since the Early Cretaceous and discuss the respective effects of far-field and near-field contributions, in order to unravel the origin of forces controlling crustal deformation. The respective contributions of mantle-scale, plate-scale and local processes in the succession of tectonic stages are discussed. Three periods can be distinguished: (1) the first period (Tethyan Tectonics), from 110 to 35 Ma, spans the main evolution of the Pyrenean orogen and the early evolution of the Betics, from rifting to maximum shortening. The rifting between Iberia and Europe and the subsequent progressive formation of new compressional plate boundaries in the Pyrénées and the Betics, as well as the compression recorded all the way to the North Sea, are placed in the large-scale framework of the African and Eurasian plates carried by large-scale mantle convection; (2) the second period (Mediterranean Tectonics), from 32 to 8 Ma, corresponds to a first-order change in subduction dynamics. It is most typically Mediterranean with a dominant contribution of slab retreat and associated mantle flow in crustal deformation. Mountain building and back-arc basin opening are controlled by retreating and tearing slabs and associated mantle flow at depth. The 3-D interactions between the different pieces of retreating slabs are complex and the crust accommodates the mantle flow underneath in various ways, including the formation of metamorphic core complexes and transfer fault zones; (3) the third period (Late-Mediterranean Tectonics) runs from 8 Ma to the Present. It corresponds to a new drastic change in the tectonic regime characterized by the resumption of N-S compression along the southern plate boundary and a propagation of compression toward the north. The respective effects of stress transmission through the lithospheric stress-guide and lithosphere-asthenosphere interactions are discussed throughout this period.