When do optic disc edema and peripheral neuropathy constitute poetry?

Brazis, Paul W.; Liesegang, Thomas J.; Bolling, James P.

doi:10.1016/0039-6257(90)90091-9

Cited by 25 publications

(16 citation statements)

References 35 publications

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“…[36][37][38][39][40][41][42][43][44][45] In the present series, we report an additional 5. Moreover, restrictive lung disease was recognized in another 5% of our patients, and 20% of deaths were related to respiratory failure.…”

Section: Less-recognized Featuresmentioning

confidence: 53%

“…2,100,117,118 Papilledema, which occurs in 29% to 55% of patients, may be asymptomatic or may cause headache, transient obscurations of vision, scotomata, enlarged blind spots, or progressive constriction of the visual field. 8,22,38,119 Sclerotic bone lesions occur in most patients. They may be solitary or multiple.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…8,22 The association between the 2 disorders is well recognized but poorly understood. 8,22,38,47,65, Endocrine abnormalities are defining features of the syndrome. 19 Primary and secondary hypothyroidism, hypogonadism, adrenocortical insufficiency, and diabetes mellitus have been described.…”

Section: Clinical Featuresmentioning

confidence: 99%

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POEMS syndrome: definitions and long-term outcome

Dispenzieri

Kyle

Lacy

et al. 2003

Blood

713

806

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The POEMS syndrome (coined to refer to polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) remains poorly understood. Ambiguity exists over the features necessary to establish the diagnosis, treatment efficacy, and prognosis. We identified 99 patients with POEMS syndrome. Minimal criteria were a sensorimotor peripheral neuropathy and evidence of a monoclonal plasmaproliferative disorder. To distinguish POEMS from neuropathy associated with monoclonal gammopathy of undetermined significance, additional criteria were included: a bone lesion, Castleman disease, organomegaly (or lymphadenopathy), endocrinopathy, edema (peripheral edema, ascites, or effusions), and skin changes. The median age at presentation was 51 years; 63% were men. Median survival was 165 months. With the exception of fingernail clubbing (P ‫؍‬ .03) and extravascular volume overload (P ‫؍‬ .04), no presenting feature, including the number of presenting features, was predictive of survival. Response to therapy (P < .001) was predictive of survival. Pulmonary hypertension, renal failure, thrombotic events, and congestive heart failure were observed and appear to be part of the syndrome. In 18 patients (18%), new disease manifestations developed over time. More than 50% of patients had a response to radiation, and 22% to 50% had responses to prednisone and a combination of melphalan and prednisone, respectively. We conclude that the median survival of patients with POEMS syndrome is 165 months, independent of the number of syndrome features, bone lesions, or plasma cells at diagnosis. Additional features of the syndrome often develop, but the complications of classic multiple myeloma rarely

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Section: Less-recognized Featuresmentioning

confidence: 53%

Section: Clinical Featuresmentioning

confidence: 99%

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POEMS syndrome: definitions and long-term outcome

Dispenzieri

Kyle

Lacy

et al. 2003

Blood

713

806

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“…There have been just a few reports on the contribution of MRI in the diagnostics of POEMS syndrome [5][6][7][8][9] . The MRI imaging in POEMS syndrome is quite rare as the diagnosis is usually based on clinical symptoms, and the MRI scans are mostly performed in situations of diagnostic uncertainty.…”

Section: Discussionmentioning

confidence: 99%

Comparison of imaging methods in POEMS syndrome

Minařík¹,

Ščudla²,

Bačovský³

et al. 2012

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Le papilloedème peut apparaître comme l'un des signes les plus précoces dans le déve- [12]. La possibilité d'un dommage direct ou d'une altération fonction nelle endothéliale, produite par un facteur in déterminé secrété par la tumeur ou la propre protéine monoclonale, serait responsable de l'accroissement de la perméabilité vasculaire.…”

Section: Discussionunclassified

Œdème de la papille et syndrome de POEMS

Turu

García²,

Reus³

et al. 1992

Ophthalmologica

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A new case of optic disk swelling associated with POEMS syndrome is described. This is a rare disease, but it should be suspected in cases of bilateral optic disk swelling when defining systemic components are present: polyneuropathy (P) organomegaly (O), endocrinopathy (E), monoclonal component (M) and skin changes (S). Usually visual acuity is maintained. However, loss of vision secondary to optic disk swelling and associated macular edema could be found.

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When do optic disc edema and peripheral neuropathy constitute poetry?

Cited by 25 publications

References 35 publications

POEMS syndrome: definitions and long-term outcome

POEMS syndrome: definitions and long-term outcome

Comparison of imaging methods in POEMS syndrome

Œdème de la papille et syndrome de POEMS

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