‘When is a hotspot a good nanospot’ – review of analytical and hotspot-dominated surface enhanced Raman spectroscopy nanoplatforms

Abstract

Substrate development in surface-enhanced Raman spectroscopy (SERS) continues to attract research interest. In order to determine performance metrics, researchers in foundational SERS studies use a variety of experimental means to...

SERS microscopy as a tool for comprehensive biochemical characterization in complex samples

“…, surfaces or 3D-structures, 27,28 and nanostructures obtained by top-down nanofabrication have several advantages over nanoparticles in droplets, as covered in a wide range of overview works and references cited therein. 29,30 They may be beneficial in the analysis of biofluids, including diagnostic applications that involve optofluidics and their incorporation into microfluidic systems. 31 They can also be used as substrates for cell cultures, e.g.…”

GaN-Based Substrates as Surface-Enhanced Raman Scattering Sensors for Penicillin G: Does the Size of the Analyte Molecule Matter?

“…After applying an appropriately selected cleaning procedure and dissolving the Ag layer in nitric acid, the substrates can be recoated with silver (or gold) and reused for SERS measurements. Therefore, although many different types of substrates (for example: self-assembled layers of silica spheres , or polystyrene spheres, , fibrous paper, zinc oxide nanorods, or silicon nanorods) are currently used for SERS measurements after deposition of a plasmonic metal, in this work we decided to use silver-coated nanostructured GaN substrates.…”