When is the perirhinal cortex necessary for the performance of spatial memory tasks?

Aggleton, John Patrick; Kyd, Rachel J.; Bilkey, David K.

doi:10.1016/j.neubiorev.2004.08.007

Cited by 62 publications

(55 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, rats with PRC lesions without previous training are able to learn the task at the same rate as the controls without learning experience, suggesting a normal performance. These data agree with previous findings showing that rats with PRC lesions, in general, do not manifest any deficit in the acquisition of several allocentric tasks in the radial maze (Bussey et al 1999;Ramos 2002;Aggleton et al 2004;Winters et al 2004). Second, during the 12 d of relearning, the perirhinal lesioned rats with preoperative training relearn the task at the same rate as the control rats without previous training.…”

Section: Discussionsupporting

confidence: 92%

“…Thus, with these paradigms, when the lesions are made after the training and retrograde amnesia is observed, it is difficult to determine if the lesions have affected the performance of the task or a process of consolidation and/or retrieval. In relation to spatial memory, although there is debate regarding the function of the PRC in acquisition (Muir and Bilkey 2001;Aggleton et al 2004), several studies have shown that rats with PRC lesions have intact acquisition in a radial maze (Bussey et al 1999; see also Winters et al 2004 in a Y-maze). For this reason, the present study uses a spatial reference memory test in a four-arm plus-shaped maze, for which our laboratory has previously shown the absence of deficits in acquisition/performance following perirhinal lesions (Ramos 2002).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Perirhinal cortex lesions produce retrograde amnesia for spatial information in rats: Consolidation or retrieval?

Ramos¹

2008

Learn. Mem.

View full text Add to dashboard Cite

Several lines of evidence in humans and experimental animals suggest that the hippocampus is critical for the formation and retrieval of spatial memory. However, although the hippocampus is reciprocally connected to adjacent cortices within the medial temporal lobe and they, in turn, are connected to the neocortex, little is known regarding the function of these cortices in memory. Here, using a reference spatial memory task in the radial maze, we show that neurotoxic perirhinal cortex lesions produce a profound retrograde amnesia when learning-surgery intervals of 1 or 50 d are used (Experiment 1). With the aim of dissociating between consolidation and retrieval processes, we injected lidocaine either daily after training (Experiment 2) or before a retention test once the learning had been completed (Experiment 3). Results show that reversible perirhinal inactivation impairs retrieval but not consolidation. However, the same procedure followed in Experiment 2 disrupted consolidation when the lidocaine was injected into the dorsal hippocampus. The results of Experiment 4 rule out the possibility that the deficit in retrieval is due to a state-dependent effect. These findings demonstrate the differential contribution of various regions of the medial temporal lobe to memory, suggesting that the perirhinal cortex plays a key role in the retrieval of spatial information for a long period of time.

show abstract

Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Perirhinal cortex lesions produce retrograde amnesia for spatial information in rats: Consolidation or retrieval?

Ramos¹

2008

Learn. Mem.

View full text Add to dashboard Cite

show abstract

“…If the Dlv lies in the most distal pallial position, and the pallium out-folds in a caudolateral direction, then the Dp would occupy a topological position comparable to that of the parahippocampal cortices of mammals and birds, that is, proximally surrounding the hippocampal pallium and interfacing it with the dorsal pallium. The parahippocampal area of mammals plays a crucial role in spatial memory [Schenk and Morris, 1985;Good and Honey, 1997;Galani et al, 1998;Aggleton et al, 2000Aggleton et al, , 2004Oswald and Good, 2000;Parron and Save, 2004;Hafting et al, 2005;Steffenach et al, 2005;Moser et al, 2008], and imaging studies have shown a persistent activation of these extrahippocampal regions during spatial memory acquisition and on recall [Aggleton et al, 2000;Poirier et al, 2008;Mullally and Maguire, 2011;Epstein and Vass, 2014;Auger et al, 2015;Chadwick et al, 2015]. Like in the present study, sustained spatial learning and memory-related increased oxidative metabolism in the parahippocampal region has been reported in rodents [Matrov et al, 2007;Conejo et al, 2013;Méndez-López et al, 2013].…”

Section: Persistent Activation Of the Dp During Spatial Memory Acquissupporting

confidence: 85%

Dynamics of Goldfish Subregional Hippocampal Pallium Activity throughout Spatial Memory Formation

Ocaña

Uceda²,

Árias³

et al. 2017

Brain Behav Evol

View full text Add to dashboard Cite

The teleost fish hippocampal pallium, like the hippocampus of tetrapods, is essential for relational map-like spatial memories. In mammals, these relational memories involve the dynamic interactions among different hippocampal subregions and between the hippocampus-neocortex network, which performs specialized operations such as memory encoding and retrieval. However, how the teleost hippocampal homologue operates to achieve comparably sophisticated spatial cognition capabilities is largely unknown. In the present study, the progressive changes in the metabolic activity of the pallial regions that have been proposed as possible homologues of the mammalian hippocampus were monitored in goldfish. Quantitative cytochrome oxidase histochemistry was used to measure the level of activation along the rostrocaudal axis of the ventral (Dlv) and dorsal parts of the dorsolateral division (Dld) and in the dorsoposterior division (Dp) of the goldfish telencephalic pallium throughout the time course of the learning process of a spatial memory task. The results revealed a significant increase in spatial memory-related metabolic activity in the Dlv, but not in the Dld, suggesting that the Dlv, but not the Dld, is comparable to the amniote hippocampus. Regarding the Dlv, the level of activation of the precommissural Dlv significantly increased at training onset but progressively declined to finally return to the basal pretraining level when the animals mastered the spatial task. In contrast, the commissural Dlv activation persisted even when the acquisition phase was completed and the animal's performance reached an asymptotic level. These results suggest that, like the dentate gyrus of mammals, the goldfish precommissural Dlv seems to respond nonlinearly to increments of change in sensory input, performing pattern separation under highly dissimilar input patterns. In addition, like the CA3 of mammals, the commissural Dlv likely operates in a continuum between two modes, a pattern separation or storage operation mode at early acquisition when the change in the sensory input is high, probably driven by the precommissural Dlv output, and a pattern completion or recall operation mode when the animals have mastered the task and the change in sensory input is small. Finally, an unexpected result of the present study is the persistent activation of the area Dp throughout the complete spatial task training period, which suggests that the Dp could be an important component of the pallial network involved in spatial memory in goldfish, and supports the hypothesis proposing that the Dp is a specialized part of the hippocampal pallium network.

show abstract

“…In addition, Herzog and Otto (1997) reported that perirhinal cortex is critical to cued but not contextual fear conditioning. These and other data have led several investigators to the view that the perirhinal cortex is specialized for identifying the memory strength of individual stimuli, and this role is evident in findings from single neuron recordings, experimental ablations, immediate early gene activation, and functional imaging in humans (Brown and Aggleton, 2001;Henson et al, 2003;Aggleton et al, 2004).…”

Section: Perirhinal Cortex and Leamentioning

confidence: 99%

Evolution of declarative memory

2006

View full text Add to dashboard Cite

The present review considers research on the hippocampus and related areas from humans and experimental animals and makes three main points. First, many of the anatomical details of the hippocampus and adjacent cortical areas in the parahippocampal region are conserved across mammals. Second, the functional role of these areas in declarative memory is also conserved across species. Third, an evolutionary approach will be key to understanding exactly how the local circuitry of the hippocampus and parahippocampal region supports declarative memory. To highlight the utility of this approach, a schematic model is described in which separate streams of spatial and nonspatial information converge on the hippocampus. By this view, a fundamental function of the mammalian hippocampus is to combine incoming information about spatial context from the postrhinal (parahippocampal in primates) cortex and medial entorhinal area with incoming information about nonspatial items from the perirhinal cortex and lateral entorhinal area. The underlying neurobiological computations that arise from local circuitry enable item-in-context memory and are proposed to be fundamental to many examples of declarative memory, including episodic memory in humans and spatial memory in experimental animals.

show abstract

When is the perirhinal cortex necessary for the performance of spatial memory tasks?

Cited by 62 publications

References 110 publications

Perirhinal cortex lesions produce retrograde amnesia for spatial information in rats: Consolidation or retrieval?

Perirhinal cortex lesions produce retrograde amnesia for spatial information in rats: Consolidation or retrieval?

Dynamics of Goldfish Subregional Hippocampal Pallium Activity throughout Spatial Memory Formation

Evolution of declarative memory

Contact Info

Product

Resources

About