When MARCH family proteins meet viral infections

Zheng, Chunfu; Tang, Yan-Dong

doi:10.1186/s12985-021-01520-4

Cited by 14 publications

(5 citation statements)

References 28 publications

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“…Fourthly, energy efficiency boost contributes to the optimization of energy structure. Zheng et al (2021) stated that one manifestation of lifted energy efficiency was the optimized energy structure. It can further enhance the effect of energy saving and emission reduction, and also accelerate the effect of resource allocation, thus further promoting the development of green economy.…”

Section: Relationship Between Energy Efficiency and Green Economic Gr...mentioning

confidence: 99%

Should energy efficiency be improved? the impact of energy efficiency improvements on green economic growth—evidence from China

Wu,

Zhu,

Cheng

et al. 2023

Front. Energy Res.

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Green economic growth is the main direction of China’s future economic development, while energy efficiency improvement—an important prerequisite for promoting the nation’s sustainable development—is a necessary way to guarantee its economic transformation and development. It is thus of great practical significance to study the relationship between energy efficiency improvement and green economic development. On the basis of analyzing the mechanism and how energy efficiency improvement influences green economic growth, this paper measures energy efficiency with the SBM model and constructs a system of green economic growth index, and verifies the relationship between energy efficiency improvement and green economic growth with an econometric model empirical analysis. It is found that, on the whole, the improvement of energy efficiency at this stage in China inhibits green economic growth. However, with the improvement of energy efficiency level, the inhibition effect gradually weakens, showing a non-linear trajectory of “inhibition–inhibition weakening”. At present, China’s energy rebound effect is still on the rise in the short term, and green economic development is restrained to a certain extent. The current expansion of the industrial sector will exacerbate resource consumption and pollutant emissions, while technological innovation and urbanization levels will alleviate the current energy rebound tension. The paper concludes with recommendations from the perspectives of the government, R&D institutions and personnel, the power sector, and urbanization.

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Section: Relationship Between Energy Efficiency and Green Economic Gr...mentioning

confidence: 99%

Should energy efficiency be improved? the impact of energy efficiency improvements on green economic growth—evidence from China

Wu,

Zhu,

Cheng

et al. 2023

Front. Energy Res.

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“…Importantly and interestingly, MARCH proteins are discovered to execute antiviral functions [ 26 ]. Tada and colleagues first reported that MARCH8 inhibited HIV-1 infection by reducing its envelope glycoprotein incorporation into virions [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

The emerging roles of MARCH8 in viral infections: A double-edged Sword

Yu,

Liu,

Zhao

et al. 2023

PLoS Pathog

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The host cell membrane-associated RING-CH 8 protein (MARCH8), a member of the E3 ubiquitin ligase family, regulates intracellular turnover of many transmembrane proteins and shows potent antiviral activities. Generally, 2 antiviral modes are performed by MARCH8. On the one hand, MARCH8 catalyzes viral envelope glycoproteins (VEGs) ubiquitination and thus leads to their intracellular degradation, which is the cytoplasmic tail (CT)-dependent (CTD) mode. On the other hand, MARCH8 traps VEGs at some intracellular compartments (such as the trans-Golgi network, TGN) but without inducing their degradation, which is the cytoplasmic tail-independent (CTI) mode, by which MARCH8 hijacks furin, a cellular proprotein convertase, to block VEGs cleavage. In addition, the MARCH8 C-terminal tyrosine-based motif (TBM) 222YxxL225 also plays a key role in its CTI antiviral effects. In contrast to its antiviral potency, MARCH8 is occasionally hijacked by some viruses and bacteria to enhance their invasion, indicating a duplex role of MARCH8 in host pathogenic infections. This review summarizes MARCH8’s antiviral roles and how viruses evade its restriction, shedding light on novel antiviral therapeutic avenues.

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“…The functions of MARCH protein family members extend beyond their role as immune receptor modulators. MARCH proteins have emerged as important antiviral factors that target a number of enveloped viruses (7). Enveloped viruses contain a lipid bilayer on the surface of the viral particle, in which viral proteins critical for virus entry localize.…”

Section: Introductionmentioning

confidence: 99%

Determining the antiviral mechanism of MARCH2

Umthong,

Timilsina,

D’Angelo

et al. 2023

Preprint

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Membrane-associated RING-CH (MARCH) 2 protein is a member of the MARCH protein family of RING-CH finger E3 ubiquitin ligases that have important functions in regulating the levels of proteins found on the cell surface. MARCH1, 2 and 8 inhibit HIV-1 infection by preventing the incorporation of the envelope glycoproteins in nascent virions. However, a better understanding on the mechanism utilized by MARCH proteins to restrict HIV-1 is needed. In this report, we identify an amino acid in human MARCH2, that is absent in mouse MARCH2, critical for its antiretroviral function. Moreover, we map the domains of human MARCH2 critical for restricting as well as binding to the HIV-1 envelope glycoproteins. Our findings reveal important new aspects of the antiviral mechanism utilized by human MARCH2 to restrict HIV-1 that have potential implications to all MARCH proteins with antiviral functions.

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When MARCH family proteins meet viral infections

Cited by 14 publications

References 28 publications

Should energy efficiency be improved? the impact of energy efficiency improvements on green economic growth—evidence from China

Should energy efficiency be improved? the impact of energy efficiency improvements on green economic growth—evidence from China

The emerging roles of MARCH8 in viral infections: A double-edged Sword

Determining the antiviral mechanism of MARCH2

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