It has often and confidently been asserted, that man's origin can never be known: but ignorance more frequently begets confidence than does knowledge: it is those who know little, and not those who know much, who so positively assert that this or that problem will never be solved by science." (Darwin "The Descent of Man" 1871, p.3). "The difference in mind between man and the higher animals, great as it is, certainly is one of degree and not of kind." (p.85) "The formation of different languages and of distinct species, and the proofs that both have been developed through a gradual process, are curiously parallel…" (p.90) "A tribe including many members who, from possessing in a high degree the spirit of patriotism, fidelity, obedience, courage, and sympathy, were always ready to aid one another, and to sacrifice themselves for the common good, would be victorious over most other tribes… [A]s morality is one important element in their success, the standard of morality and the number of well-endowed men will thus everywhere tend to rise and increase." (p.148) This year we are celebrating the 150th anniversary of Darwin's book "The Descent of Man", in which he laid down the foundation for scientific studies of human origins. We now have a much better understanding of how new species arise and adapt to their environments-the process which Charles Darwin called a "mystery of mysteries" (Darwin 1859, Coyne and Orr 2004, Gavrilets 2004) and we have begun to offer evolutionary accounts of the origin of our own species. Studying human origins necessarily implies a comparison with our close relatives, the other primates, and with other social animals. Research on human origins and our subsequent cultural and social evolution is vital not only for foundational scientific discovery but also for understanding, mitigating, and solving the most pressing challenges faced by our society. Advancing research on human origins and social complexity is also very timely given recent advances and emerging opportunities. Fully capitalizing on these requires a concerted transdisciplinary effort of researchers from a diverse set of disciplines. Success in this endeavor could yield tremendous gains for society.