When Marking Nut Traveled to Washington, DC

Kubba, Ali; Batrani, Meenakshi; Vadrevu, Ravi

doi:10.1097/der.0000000000000173

Cited by 1 publication

(1 citation statement)

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“…It has been used as neurotonic formulation since a time ago in Ayurveda [28]. It have been reported by scientific study recently to posse various properties like hypoglycemic, antiatherogenic, antimicrobial, antioxidant, anticarcinogenic, antiinflammatory, anti-reproductive, CNS stimulant, skin diseases and hair growth promoter [28][29][30][31][32][33]. It shows in vitro antioxidant properties and induces cytotoxicity in liver, lung [34,35], breast, leukaemia, cervical cancer cells [36,37] through induction of apoptosis [37,38].…”

Section: Introductionmentioning

confidence: 99%

Virtual screening of MAP-Tauprotein inhibitors fromSemecarpus anacardiumLinn. leaf extract for cancer prevention

Singh

Ranjan

Tripathi

et al. 2020

Preprint

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Semecarpus anacardium is a well known Indian medicinal plant with various medicinalproperties like hypoglycemic, antioxidant, anticancer, anti-inflammatory, anti-geriatric, antimicrobial and hair growth promoter, etc. The molecular mechanism of metabolites from fruiting bodies of S. anacardium against cancer has been described but anticancerous properties in its leaves are still unknown. The leaves were extracted in petroleum ether, ethyl acetate and methanol and assayed for anticancer activity using MTT assay. The active extract was evaluated for mode of cell death induction using EtBr-AO double staining and analyzed for phytochemical constituents using GC-MS, followed by molecular docking studies for exploration of possibility for anticancer agents and Drugability. In this study, ethyl acetate extract of leaf was found potent cytotoxic in MCF-7 cells and also induced apoptosis. It has also found the SLE is safe for normal cells. The molecular docking studies were done to explore the probable mechanism of action of the extract which showed 9 compounds are targeting the microtubule-associated protein tau (MAPT). MAPT promotes assembling and prevents disassembling to arrest the cell cycle. The overexpression of MAPT induces chemoresistance to cancerous cells against conventional drugs like paclitaxel. We have identified 17 compounds from ethyl acetate extract of S. anacardium leaves and drawn its chemical structure by using chembiodraw software to transform into pdb format. Further, the compounds have been subjected for molecular docking study to investigate its interactive efficiency with MAPT protein. The compound 13 had higher interactive potential to MAPT with binding energy -31.75 kcal/mol and lowest binding energy (-15.44 kcal/mol) was observed in compound 6. The present study suggested that the compounds from leaves of S. anacardium could be alternative approach of conventional drug for cancer treatment with cost effective and less side effect.

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