2022
DOI: 10.1007/s11071-022-07548-7
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When might host heterogeneity drive the evolution of asymptomatic, pandemic coronaviruses?

Abstract: Controlling many infectious diseases, including SARS-Coronavirus-2 (SARS-CoV-2), requires surveillance followed by isolation, contact-tracing and quarantining. These interventions often begin by identifying symptomatic individuals. However, actively removing pathogen strains causing symptomatic infections may inadvertently select for strains less likely to cause symptomatic infections. Moreover, a pathogen’s fitness landscape is structured around a heterogeneous host pool; uneven surveillance efforts and disti… Show more

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Cited by 3 publications
(1 citation statement)
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“…Theoretical studies on the evolution of detection avoidance have primarily focused on selection for asymptomatic infections (Saad-Roy et al 2020; Okamoto et al 2023), and by comparison relatively little is known about escape from diagnostic testing. As far as we are aware, only three studies have explored the evolution of detection avoidance arising from diagnostic testing.…”
Section: Introductionmentioning
confidence: 99%
“…Theoretical studies on the evolution of detection avoidance have primarily focused on selection for asymptomatic infections (Saad-Roy et al 2020; Okamoto et al 2023), and by comparison relatively little is known about escape from diagnostic testing. As far as we are aware, only three studies have explored the evolution of detection avoidance arising from diagnostic testing.…”
Section: Introductionmentioning
confidence: 99%