When pharmaceutical drugs become environmental pollutants: Potential neural effects and underlying mechanisms

Vaudin, Pascal; Augé, Corinne; Just, Nathalie; Mhaouty-Kodja, Sakina; Mortaud, Stéphane; Pillon, Delphine

doi:10.1016/j.envres.2021.112495

Cited by 47 publications

(12 citation statements)

References 192 publications

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“…For instance, pollutants can alter an individual's metabolic state, leading to increased foraging and activity [27]. Changes to neurological and cognitive function can occur when contaminants mimic or block the actions of neurotransmitters, neurohormones, or steroid hormones that modulate animal behaviour [28]. Chemical exposure can also disrupt neurological function by impacting the expression of key receptors for signalling molecules, the functionality of enzymes, or the modulation of neural transmission via de-or hyperpolarisation [29].…”

Section: How Do Chemical Pollutants Impact Individuals?mentioning

confidence: 99%

Predicting the impacts of chemical pollutants on animal groups

Michelangeli

Martin

Pinter‐Wollman

et al. 2022

Trends in Ecology & Evolution

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Section: How Do Chemical Pollutants Impact Individuals?mentioning

confidence: 99%

Predicting the impacts of chemical pollutants on animal groups

Michelangeli

Martin

Pinter‐Wollman

et al. 2022

Trends in Ecology & Evolution

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“…Pharmaceuticals are primarily used to treat, prevent, and diagnose diseases in humans and animals. However, over time, pharmaceutical production and consumption have grown, making them one of the emerging environmental contaminants [ 110 , 111 ]. Due to their widespread detection, their ongoing release into ecosystems has grown into a severe problem, causing serious health effects in humans, animals, and plants.…”

Section: Types Of Analytes Extractedmentioning

confidence: 99%

A Review: Subcritical Water Extraction of Organic Pollutants from Environmental Matrices

Yabalak,

Aminzai,

Gizir

et al. 2024

Molecules

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Most organic pollutants are serious environmental concerns globally due to their resistance to biological, chemical, and photolytic degradation. The vast array of uses of organic compounds in daily life causes a massive annual release of these substances into the air, water, and soil. Typical examples of these substances include pesticides, polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs). Since they are persistent and hazardous in the environment, as well as bio-accumulative, sensitive and efficient extraction and detection techniques are required to estimate the level of pollution and assess the ecological consequences. A wide variety of extraction methods, including pressurized liquid extraction, microwave-assisted extraction, supercritical fluid extraction, and subcritical water extraction, have been recently used for the extraction of organic pollutants from the environment. However, subcritical water has proven to be the most effective approach for the extraction of a wide range of organic pollutants from the environment. In this review article, we provide a brief overview of the subcritical water extraction technique and its application to the extraction of PAHs, PCBs, pesticides, pharmaceuticals, and others form environmental matrices. Furthermore, we briefly discuss the influence of key extraction parameters, such as extraction time, pressure, and temperature, on extraction efficiency and recovery.

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“…This has led to a significant increase in pharmaceutical contamination in water resources, presenting a major global environmental challenge. The aim is therefore to remove pharmaceutical contaminants from the environment, where they are even harmful at trace concentrations [ 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on the Removal Efficiency of Clomazone and Amitriptyline via Adsorption and Photocatalysis in Aqueous Media: Kinetic Models and Toxicity Assessment

Tot,

Despotović,

Panić

et al. 2024

Materials

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This study aimed to compare the effectiveness of adsorption and photocatalysis techniques at removing the herbicide clomazone (CLO) and the antidepressant known as amitriptyline (AMI) from water. This study employed kinetic models to analyze the removal processes and assess the potential toxicity of the treated water. The structure and morphology of the prepared multi-walled carbon nanotubes were characterized as adsorbents by transmission electron microscopy, X-ray diffraction, Fourier transform infrared techniques, and Raman spectroscopy. The adsorption kinetics of CLO and AMI were studied on the pristine and functionalized multi-walled carbon nanotubes. Kinetic studies were performed by modeling the obtained experimental data using three kinetic models: pseudo-first-order, pseudo-second-order, and Elovich kinetic models. On the other hand, the efficiency of CLO and AMI photodegradation was examined as a function of the type of irradiation (UV and simulated solar irradiation) and type of TiO2 photocatalyst (Aeroxide and Kronos). Under the experimental conditions employed, the reaction followed pseudo-first-order kinetics. Additionally, in order to assess the toxicity of water containing CLO, AMI, and their intermediates, toxicity assessments were conducted using human fetal lung fibroblast cells. The results obtained indicate the effectiveness of both methods and provide valuable insights into their removal mechanisms, contributing to the advancement of sustainable water treatment strategies.

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When pharmaceutical drugs become environmental pollutants: Potential neural effects and underlying mechanisms

Cited by 47 publications

References 192 publications

Predicting the impacts of chemical pollutants on animal groups

Predicting the impacts of chemical pollutants on animal groups

A Review: Subcritical Water Extraction of Organic Pollutants from Environmental Matrices

Comparative Study on the Removal Efficiency of Clomazone and Amitriptyline via Adsorption and Photocatalysis in Aqueous Media: Kinetic Models and Toxicity Assessment

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