When repeated <scp><i>Helicobacter pylori</i></scp> therapies fail, what should we do?

Wong, Sunny H.; Sung, Joseph J.Y.

doi:10.1111/jgh.14668

Cited by 1 publication

(1 citation statement)

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“…Antibiotic resistance is increasing in recent years in a varying pattern among different countries. While clarithromycin resistance is markedly reported, fortunately, AMX resistance is still rare in many areas [3,7,8]. Accordingly, the failure of clarithromycin-based therapy in achieving a high cure rate in some patients shifted the attention to the use of AMX/MET with a PPI.…”

Section: Introductionmentioning

confidence: 99%

An eco‐friendly multi‐analyte high‐performance thin layer chromatographic densitometric determination of amoxicillin, metronidazole, and famotidine in their ternary mixtures and simulated gastric juice: A promising protocol for eradicating Helicobacter pylori

Ragab

Maher

Tarek

et al. 2022

J of Separation Science

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Gastrointestinal tract disorders constitute a heavy burden to healthcare providers. To eradicate Helicobacter pylori infection, different triple therapy protocols have been proposed. Among which are combinations of proton pump inhibitors (e.g., omeprazole), histamine‐2 receptor antagonists (e.g., famotidine), along with antibiotics (e.g., amoxicillin). In this work, a sensitive and accurate high‐performance thin‐layer chromatographic method was developed for the simultaneous determination of amoxicillin, metronidazole, and famotidine in bulk powder and laboratory‐prepared combined‐tablet mixtures. Complete separation of the cited compounds was achieved using pre‐coated silica gel plates with a mixture of methanol:chloroform:toluene:water:glacial acetic acid (5:2:1.5:0.5:0.1 v/v/v/v/v) as the mobile phase. The method was fully validated as per the international conference of harmonization guidelines. Good linearity, a correlation coefficient of 0.9991, was obtained in the concentration ranges 0.1–1.6 μg/band (amoxicillin), 0.1–0.9 μg/band (metronidazole), and 0.1–0.9 μg/band (famotidine). Since the method allowed the determination of the three compounds in combined tablets with a high degree of selectivity, accuracy, precision, with cost‐effectiveness, it could be used for regular quality control. Moreover, the applicability of the proposed method was extended to the determination of the ternary mixture in simulated gastric juice. Method greenness was assessed using different green metrics.

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Section: Introductionmentioning

confidence: 99%