When should old therapies be abandoned? A modern look at old studies on topical ampicillin

Charalambous, Charalambos Panayiotou; Tryfonidis, M.; Swindell, Rick; Lipsett, A.Pamela

doi:10.1016/s0163-4453(03)00071-9

Cited by 23 publications

(14 citation statements)

References 19 publications

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“…21,22 But according to Platt et al, who conducted a study to evaluate the use of perioperative prophylaxis in clean surgeries, there was an absolute decrease in the risk of surgical site infection to approximately 50%. 23,24,25 In this study, the sample size (n = 1000 ) was sufficiently larger than our study. More the number of procedures performed, more the sample size, more the power of study which makes the results of study considerably reliable.…”

Section: Discussion and Summarymentioning

confidence: 82%

Role of Prophylactic Antibody to Prevent the Surgical Site Infections - A Study in A Tertiary Care Hospitals

Karuppaiah¹

2017

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Section: Discussion and Summarymentioning

confidence: 82%

Role of Prophylactic Antibody to Prevent the Surgical Site Infections - A Study in A Tertiary Care Hospitals

Karuppaiah¹

2017

jmscr

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“…The benefits of local drug delivery system include high and sustained local concentration, minimized systemic toxicity and adverse reactions, reduced problems with patient compliance, and less chance of development of resistant strains and superimposed infections. 17 A faster healing was evident during the follow-up.…”

Section: Discussionmentioning

confidence: 88%

Local Drug Delivery as an Adjunct to Surgical Intervention in the Management of Periapical Cyst

Babu¹,

Chandran²,

Vivekchand³

et al. 2012

Conservative Dentistry and Endodontic Journal

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Radicular cysts are the most common cystic lesions affecting the jaws. They arise from the epithelial remnants in the periodontal ligament as a result of the stimulus from periapical infection following pulpal necrosis. Treatment options to manage large periapical lesions range from nonsurgical root canal treatment or apical surgery to extraction. New approaches involve the use of local drug delivery systems based on microparticles/ nanoparticles made from biocompatible polymers along with surgical intervention. Such devices enable the introduction of antimicrobial agents or other drugs directly in the periradicular area or inside the root canal, and the prolonged release of constant concentrations of these agents for fast and better healing. The present case report illustrates the combined endodontic and surgical management of a large periapical cyst with local drug delivery as an adjunct.

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“…A meta-analysis comparing appendectomy and colorectal surgery patients with and without systemic antibiotic prophylaxis demonstrated the surgical site infection benefit of topical antibiotic disappeared when using routine, prophylactic systemic antibiotics. 8 …”

Section: Areas To Incorporate Antibiotic Stewardship Into Surgical Prmentioning

confidence: 99%

Treating Wisely

et al. 2017

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Antibiotic resistance continues to receive national attention as a leading public health threat. In 2015, President Barack Obama proposed a National Action Plan to Combat Antibiotic-Resistant Bacteria to curb the rise of “superbugs,” bacteria resistant to antibiotics of last resort. Whereas many antibiotics are prescribed appropriately to treat infections, there continue to be a large number of inappropriately prescribed antibiotics. Although much of the national attention with regards to stewardship has focused on primary care providers, there is a significant opportunity for surgeons to embrace this national imperative and improve our practices. Local quality improvement efforts suggest that antibiotic misuse for surgical disease is common. Opportunities exist as part of day-to-day surgical care as well as through surgeons' interactions with nonsurgeon colleagues and policy experts. This article discusses the scope of the antibiotic misuse in surgery for surgical patients, and provides immediate practice improvements and also advocacy efforts surgeons can take to address the threat. We believe that surgical antibiotic prescribing patterns frequently do not adhere to evidence-based practices; surgeons are in a position to mitigate their ill effects; and antibiotic stewardship should be a part of every surgeons' practice.

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When should old therapies be abandoned? A modern look at old studies on topical ampicillin

Cited by 23 publications

References 19 publications

Role of Prophylactic Antibody to Prevent the Surgical Site Infections - A Study in A Tertiary Care Hospitals

Role of Prophylactic Antibody to Prevent the Surgical Site Infections - A Study in A Tertiary Care Hospitals

Local Drug Delivery as an Adjunct to Surgical Intervention in the Management of Periapical Cyst

Treating Wisely

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