When the brain remembers, but the patient doesn’t: Converging fMRI and EEG evidence for covert recognition in a case of prosopagnosia

Simon, Stéphane; Khateb, Asaïd; Darqué, Alexandra; Lazeyras, François; Mayer, Eugene P.; Pegna, Alan J.

doi:10.1016/j.cortex.2010.07.009

Cited by 24 publications

(17 citation statements)

References 80 publications

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“…This corroborates that memories of face were covertly retrieved in FE despite his severe prosopagnosia. Note that face-identification activity was not found in these areas in PS (the other case of AP submitted to a similar test; Simon et al, 2010), nor in a sample of CP cases ). The discrepancy could be due to the use of famous faces in these studies, instead of the faces of personal acquaintances used in FE (since the former elicit smaller BOLD responses; Gobbini et al, 2004).…”

Section: Discussionmentioning

confidence: 88%

“…This contrast can be examined in AP using faces learned before the disorder, with differential responses indicating the retrieval of face memories not available to consciousness. Two previous studies have reported this test with conflicting results: one with significant face-identity effects in a case of AP (Simon et al, 2010), and another with negative results for a group of CP .…”

Section: Introductionmentioning

confidence: 82%

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Covert face recognition without the fusiform-temporal pathways

et al. 2011

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 82%

Covert face recognition without the fusiform-temporal pathways

et al. 2011

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“…The involvement of both left and right ventral cerebral regions has been suggested as a possible substrate of prosopagnosia (Barton et al, 2010; Benson et al, 1974; Kay and Levin, 1982; Kleinschmidt and Cohen, 2006; Sorger et al, 2007; Takahashi et al, 1995; Thomas et al, 2009). In this framework, the damage to the ILF (Fox et al, 2008; Ishai, 2008) can disconnect face-processing areas located in the inferior occipital and fusiform gyri from more anterior regions in the temporal and frontal lobes (Alexander et al, 2007; Giussani et al, 2009; Rapcsak et al, 2001; Simon et al, 2011), which in turn may result in deficits in the ability to recognize known faces.…”

Section: Discussionmentioning

confidence: 99%

Ventral and dorsal visual streams in posterior cortical atrophy: A DT MRI study

Migliaccio

Agosta

Scola

et al. 2012

Neurobiology of Aging

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Using diffusion tensor magnetic resonance imaging tractography, ventral (inferior longitudinal fasciculus) and fronto-occipital (inferior fronto-occipital fasciculus) and dorsal (fronto-parietal superior longitudinal fasciculus) visual pathways were assessed in 7 patients with posterior cortical atrophy (PCA), showing either predominantly ventral or additional dorsal cognitive deficits. Corpus callosum and corticospinal tracts were also studied. Gray and white matter atrophy was assessed using voxel-based morphometry. In all PCA patients, abnormal diffusivity indexes were found in bilateral inferior longitudinal fasciculus and inferior fronto-occipital fasciculus, with a left-side predominance. Patients also had mild microstructural damage to the corpus callosum. The 2 patients with more dorsal symptoms also showed right fronto-parietal superior longitudinal fasciculus abnormalities. Corticospinal tracts were normal, bilaterally. When studied separately, patients with ventral clinical impairment showed a pattern of atrophy mainly located in the ventral occipitotemporal regions, bilaterally; patients with both ventral and dorsal clinical deficits showed additional atrophy of the bilateral inferior parietal lobe. Magnetic resonance imaging patterns of abnormalities mirror closely the clinical phenotypes and could provide reliable ante mortem markers of tissue damage in PCA.

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“…Functional outcome may be also measured by creating special conditions for studying impaired skills under which latent function becomes apparent. Sometimes the brain registers information that the patient cannot report (Simon et al, 2011). Individuals with hemispherectomy for infantile seizures discriminate textures with the hand ipsilateral to the hemispherectomy (although not with the contralateral hand).…”

Section: What To Assessmentioning

confidence: 99%

Functional Plasticity in Childhood Brain Disorders: When, What, How, and Whom to Assess

et al. 2014

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At every point in the lifespan, the brain balances malleable processes representing neural plasticity that promote change with homeostatic processes that promote stability. Whether a child develops typically or with brain injury, his or her neural and behavioral outcome is constructed through transactions between plastic and homeostatic processes and the environment. In clinical research with children in whom the developing brain has been malformed or injured, behavioral outcomes provide an index of the result of plasticity, homeostasis, and environmental transactions. When should we assess outcome in relation to age at brain insult, time since brain insult, and age of the child at testing? What should we measure? Functions involving reacting to the past and predicting the future, as well as social-affective skills, are important. How should we assess outcome? Information from performance variability, direct measures and informants, overt and covert measures, and laboratory and ecological measures should be considered. In whom are we assessing outcome? Assessment should be cognizant of individual differences in gene, socio-economic status (SES), parenting, nutrition, and interpersonal supports, which are moderators that interact with other factors influencing functional outcome.

show abstract

When the brain remembers, but the patient doesn’t: Converging fMRI and EEG evidence for covert recognition in a case of prosopagnosia

Cited by 24 publications

References 80 publications

Covert face recognition without the fusiform-temporal pathways

Covert face recognition without the fusiform-temporal pathways

Ventral and dorsal visual streams in posterior cortical atrophy: A DT MRI study

Functional Plasticity in Childhood Brain Disorders: When, What, How, and Whom to Assess

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