When the Child's heart fails: Recognition, treatment, prognosis

Engle, Mary Allen

doi:10.1016/0033-0620(70)90023-x

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Historical Perspective1

Therapy Of Hf In Children1

Congenital Heart Disease: Volume Overload1

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1972

2019

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Cited by 7 publications

(3 citation statements)

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“…[7][8][9][10] Figure shows one of the popular approaches from this era for assisting ventilatory mechanics. 10 Outcomes were described (mortality rates varied from 49% to 85%), but there was no correlation of cause or treatment with outcome.…”

Section: Historical Perspectivementioning

confidence: 99%

Heart Failure in Children

Hsu

Pearson

2009

Circ: Heart Failure

169

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Section: Historical Perspectivementioning

confidence: 99%

Heart Failure in Children

Hsu

Pearson

2009

Circ: Heart Failure

169

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“…In history, the most important aim of HF therapy was to improve symptoms, so bedding children in upright position (10) and treating dyspnea and pulmonary congestion by diuretics (11). Continuing to the present, evidence-based clinical trials in children are still missing and recommendations are predicated on clinician's experience.…”

Section: Therapy Of Hf In Childrenmentioning

confidence: 99%

Pediatric heart failure therapy: why β1-receptor blocker, tissue ACE-I and mineralocorticoid-receptor-blocker?

et al. 2019

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HF defines a condition in which the heart is unable to fulfill the body's need of blood supply. The reason of this inability is either known or idiopathic. Cardiac output is not only a sum of myocardial contractility, heart frequency, heart rhythm, preload and afterload, but is also related to contractile synchrony, interventricular interaction, as well as atrial-ventricular and ventricular-arterial coupling. Therefore, every single component or the sum of all components can lead to an insufficient heart function. Pediatric HF is related to genetic and metabolic abnormalities, structural diseases with volume or pressure overload, hypoxemia, arrhythmias or caused by myocardial disease. Clinical symptoms are dependent on the severity of HF, but also related to age and the cause of HF (1).New York Heart Association (NYHA) functional classification is not suitable to the young pediatric

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“…Digitalis was considered an essential component of pediatric heart failure therapy by the 1960s. 27,28 Subsequently, it became clear that the evidence for efficacy was at best contradictory, especially in volume-overload lesions with normal function, where the mild inotropic effect of digitalis was unnecessary. 29 However, digitalis also has sympatholytic properties, 30 which may modulate pathological neurohormonal activation.…”

Section: Congenital Heart Disease: Volume Overloadmentioning

confidence: 99%