When the heart is burning: Amino-terminal pro-brain natriuretic peptide as an early marker of cardiac involvement in active autoimmune rheumatic disease

Giannoni, Alberto; Tani, Chiara; Clerico, Aldo; Passino, Claudio; Tavoni, Antonio; d’Ascanio, A.; Bombardieri, Stefano; Emdin, Michele

doi:10.1016/j.ijcard.2009.10.048

Cited by 16 publications

(20 citation statements)

References 29 publications

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“…Some authors confirmed the relationship between RV and LV diastolic function in SSc, but with a modest number of echocardiographic parameters. 25,26 Our investigation revealed that BNP level significantly correlated with LV and RV systolic and global function in SSc patients, which gives clinicians the opportunity to expand the usage of BNP which has been mostly replaced with new biomarker (pro-BNP) in recent studies. 20 The neuroendocrine characteristics of patients with SSc have been widely studied in the last few years.…”

Section: Discussionmentioning

confidence: 82%

“…However, Vonk 4 However, authors stated that other factors, as age, gender, and arterial blood pressure, influenced LV abnormalities. [21][22][23][24][25][26][27][28] Other researchers showed that the BNP and NT-pro-BNP correlated well with SPAP, PVR, survival, NYHA functional class, exercise capacity, and cardiopulmonary hemodynamics in SSc patients. Some authors confirmed the relationship between RV and LV diastolic function in SSc, but with a modest number of echocardiographic parameters.…”

Section: Discussionmentioning

confidence: 97%

“…Our study showed that the BNP level was higher in SSc patients compared to the controls, which confirmed the results of previous investigations. [21][22][23][24][25][26][27][28] Other researchers showed that the BNP and NT-pro-BNP correlated well with SPAP, PVR, survival, NYHA functional class, exercise capacity, and cardiopulmonary hemodynamics in SSc patients. [21][22][23][24] However, the relationship between neuroendocrine peptides with the RV and LV function was poorly investigated and had been mainly based on NT-pro-BNP.…”

Section: Discussionmentioning

confidence: 97%

See 2 more Smart Citations

Which Factors Impact Myocardial Function in Systemic Sclerosis?

Ivanović

Tadić

Zlatanović³

et al. 2011

Echocardiography

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

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Which Factors Impact Myocardial Function in Systemic Sclerosis?

Ivanović

Tadić

Zlatanović³

et al. 2011

Echocardiography

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“…The best studied cardiac biomarkers in SSc have been the natriuretic peptides [20,31–36]. Thus far, BNP and NT-proBNP have been studied primarily as biomarkers for the identification of PAH in most studies of SSc patients.…”

Section: Natriuretic Peptidesmentioning

confidence: 99%

Systemic sclerosis and the heart

Desai

Lee

Shah

2011

Current Opinion in Rheumatology

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Purpose of review When present clinically, cardiac involvement in systemic sclerosis (SSc) is a major risk factor for death. It is therefore vitally important to understand the epidemiology, screening, diagnosis, and treatment of the cardiac manifestations of SSc. Recent findings The epidemiology of cardiac involvement in SSc has been the subject of several recent studies. Most importantly, the prevalence of overt left ventricular (LV) systolic dysfunction and its associated risk factors have been defined, and patients with diffuse cutaneous SSc appear to be most susceptible to direct cardiac involvement. From a diagnostic and screening standpoint, tissue Doppler echocardiography and natriuretic peptides have provided fresh insight into subclinical cardiac dysfunction in SSc. Newer techniques, such as speckle-tracking echocardiography, diffuse myocardial fibrosis imaging, and absolute myocardial perfusion imaging, are poised to further advance our knowledge. Lastly, there is now consistent observational data to suggest a central role for calcium channel blockers in the treatment of microvascular ischemia and prevention of overt LV systolic dysfunction, although randomized controlled trials are lacking. Summary Recent studies have improved our understanding of cardiac involvement in SSc. Nevertheless, key questions regarding screening, diagnosis, and treatment remain. Novel diagnostic techniques and multicenter studies should yield important new data, which will hopefully ultimately result in improved outcomes.

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“…BNP is a cardiac hormone synthesized as a pre-propeptide, mainly expressed in the ventricle, when left ventricular function is insufficient. It is also reported that BNP is a hallmark for maladaptive remodelling of the left ventricular function, because myocardial expansion and rapid synthetic released into the blood can help to regulate cardiac function [21,22]. BNP gene encoded by BNP consists of three exons and two introns, which is located in the short arm of chromosome 1, produced by the cardiomyocytes in the capacity of overloaded stress.…”

Section: Introductionmentioning

confidence: 99%

Hypermethylation of brain natriuretic peptide gene is associated with the risk of rheumatic heart disease

Zheng

et al. 2017

Bioscience Reports

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To investigate the contribution of brain natriuretic peptide (BNP) promoter DNA methylation to the risk of rheumatic heart disease (RHD) and the influence of warfarin anticoagulant therapy on BNP methylation levels for RHD patients after surgery. BNP methylation levels were determined by bisulfite pyrosequencing from plasma samples of RHD patients compared with healthy controls. Several factors influencing the RHD patients were included like age, smoking and cholesterol levels. A fragment of five CG sites (CpG1–5) in the promoter region of BNP gene was measured. BNP gene hypermethylation was found in CpG4 and CpG5 in RHD patients compared with non-RHD controls. A significant difference was also observed between RHD patients with long-term administration of warfarin and RHD patients who had recently undergone an operation. Moreover, single CpG4 and CpG5 analysis revealed a significant increase in methylation levels in men. BNP gene body hypermethylation is associated with the risk of RHD, and also influenced by the warfarin anticoagulant therapy of RHD patients after surgery, which could represent novel and promising targets for therapeutic development.

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When the heart is burning: Amino-terminal pro-brain natriuretic peptide as an early marker of cardiac involvement in active autoimmune rheumatic disease

Cited by 16 publications

References 29 publications

Which Factors Impact Myocardial Function in Systemic Sclerosis?

Which Factors Impact Myocardial Function in Systemic Sclerosis?

Systemic sclerosis and the heart

Hypermethylation of brain natriuretic peptide gene is associated with the risk of rheumatic heart disease

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