2007
DOI: 10.1111/j.1600-065x.2007.00487.x
|View full text |Cite
|
Sign up to set email alerts
|

When three is not a crowd: a Crossregulation Model of the dynamics and repertoire selection of regulatory CD4+ T cells

Abstract: Regulatory CD4(+) T cells, enriched in the CD25 pool of healthy individuals, mediate natural tolerance and prevent autoimmune diseases. Despite their fundamental and potential clinical significance, regulatory T (T(R)) cells have not yet been incorporated in a coherent theory of the immune system. This article reviews experimental evidence and theoretical arguments supporting a model of T(R) cell dynamics, uncovering some of its most relevant biological implications. According to this model, the persistence an… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

4
94
0

Year Published

2007
2007
2015
2015

Publication Types

Select...
5
3

Relationship

4
4

Authors

Journals

citations
Cited by 67 publications
(98 citation statements)
references
References 114 publications
(172 reference statements)
4
94
0
Order By: Relevance
“…Despite the precedents in the literature (7)(8)(9)(10)(11), few reports of the influence of Teffs on Tregs are as clear and informative as the one presented by Grinberg-Bleyer et al in this issue of the JCI (6). In their study, the authors investigated the effect of Teffs on Tregs using mouse models of autoimmune diabetes.…”
Section: A Feedback Loop Between Tregs and Teffs In Type 1 Diabetesmentioning
confidence: 93%
“…Despite the precedents in the literature (7)(8)(9)(10)(11), few reports of the influence of Teffs on Tregs are as clear and informative as the one presented by Grinberg-Bleyer et al in this issue of the JCI (6). In their study, the authors investigated the effect of Teffs on Tregs using mouse models of autoimmune diabetes.…”
Section: A Feedback Loop Between Tregs and Teffs In Type 1 Diabetesmentioning
confidence: 93%
“…The success of vaccines on these class of tumors derives from the fact that, in our model, the stringency of the regulation exerted by T R cells over T E cells is a function of the ratio of T R cells per APCs (value of R/A) in the system and not of the ratio of T R cells per T E cells (values of R/E). We have proved theoretically this property of our model (24 -26), and we have shown experimentally that such a dependency is observed at least for the suppression exerted by CD4 ϩ CD25 ϩ T cells over the proliferation of CD4 ϩ CD25 Ϫ T cells when cocultured with APCs in vitro (24,27). Thus, following the latter property, vaccines that suddenly increases the number of APCs may be expected to induce rejection of GRϩ tumor, because they reduce the ratio R/A in the system, relaxing tolerance and favoring the expansion of the T E cells.…”
Section: Response To Vaccinationmentioning
confidence: 57%
“…These feedback mechanisms may involve (i) indirect interactions among cells such as a competition for limited growth factors, and (ii) direct interactions, such as contact inhibition. These two principles are the foundation of the crossregulation model, and have been justified extensively in Carneiro et al [35]. Below, we outline the model and highlight its key properties that are later embodied distributedly in a multiagent system.…”
Section: Crossregulation Modelmentioning
confidence: 95%
“…2.2, and [36]). These model parameters are set from knowledge of the underlying biology; wherein, the T-cell-APC interaction rates are known to be orders of magnitude faster than T-cell proliferation and death rates [35]. The equations for E i (eq.…”
Section: Mathematical Formulation Of the Modelmentioning
confidence: 99%
See 1 more Smart Citation