When wrinkles appear on the immune system can it be reversed?

Sibaii, Hiba; El-Zayat, Salwa Refat; Khalil, M.

doi:10.1684/ecn.2020.0441

Cited by 2 publications

(1 citation statement)

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“…An increasingly detailed understanding of mechanisms underlying immunosenescence is leading to the development of anti-immunosenescence and anti-inflammaging strategies. These include adopting a healthy diet, engaging in regular exercise, getting restorative sleep, avoiding stress, staying hydrated, using probiotics, receiving regular vaccine boosters, and considering the therapeutic potential of hormonal treatments and vitamin D supplementation [16][17][18]. From what has been discussed so far, the skin represents the first line of defense against external insults with its structural and immune cells playing crucial roles.…”

Section: Skin Immunosenescence: Structural and Functional Hallmarksmentioning

confidence: 99%

Immunosenescence and Skin: A State of Art of Its Etiopathogenetic Role and Crucial Watershed for Systemic Implications

Papa

Pomi

Borgia

et al. 2023

IJMS

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Immunosenescence is a complex multifactorial phenomenon consisting of wide-ranging remodeling of the immune system during the life span, resulting in an age-related qualitative–quantitative decline of immune cells and cytokines. A growing body of evidence in the international literature is highlighting the etiopathogenetic role of skin immunosenescence in the onset of various dermatologic conditions. Skin immunosenescence also serves as an interesting watershed for the onset of system-wide conditions in the context of allergic inflammation. Moreover, in recent years, an increasingly emerging and fascinating etiopathogenetic parallelism has been observed between some mechanisms of immunosenescence, both at cutaneous and systemic sites. This would help to explain the occurrence of apparently unconnected comorbidities. Throughout our review, we aim to shed light on emerging immunosenescent mechanisms shared between dermatologic disorders and other organ-specific diseases in the context of a more extensive discussion on the etiopathogenetic role of skin immunosenescence. A promising future perspective would be to focus on better understanding the mutual influence between skin and host immunity, as well as the influence of high inter-individual variability on immunosenescence/inflammaging. This can lead to a more comprehensive “immunobiographic” definition of each individual.

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Section: Skin Immunosenescence: Structural and Functional Hallmarksmentioning

confidence: 99%