Our most pressing societal problems such as enhancing health care, developing alternate energy, revitalizing cities, and advancing the economy are complex innovation eco-systems. Complex innovation eco-systems are the next frontier in technology and innovation management, and require a transformation in strategic and institutional management so that managers can muster the staying power to persist and learn far into the future. I develop a framework to explain how participants can strategize across an entire eco-system, deal with the profound ambiguity from complexity, and handle the very long cycle times of complex innovations. Transformed strategic and institutional management combines abductive learning routines with clock-time and event-time pacing to map a portfolio of value creating opportunities far into the future. Eco-system participants use learning events, which represent available knowledge, to hypothesize new value creating opportunities and new kinds of governance structures for specific collaborations, evaluate these opportunities and governance structures by trying them out to explore assumptions and surface new possibilities, and reframe them over time.Many of society's most pressing problems are complex innovation eco-systems. Pharmaceuticals, health care more generally, alternate energy systems, climate control, education, and myriad social problems rely on ongoing innovation to continually generate new projects, products, programs, processes, capabilities, and value creation opportunities that address these critical challenges. These "grand challenges" (Ferraro et al. 2015) represent the next frontier in technology and innovation management, because they require new theory for managing multiple organizations, agents, and agencies, and new theory for collaborative learning about the co-evolution of sciences and technologies among vast, globally dispersed networks of knowledge workers.Taking advantage of emergence (Dougherty 2016) is a central capability around which new theories for complex innovation eco-systems will build. Innovators in complex eco-systems must take advantage of the emergence of knowledge about sciences, technologies, user needs, delivery systems and so on for their new products and programs, because knowledge for innovation does not already exist. Taking advantage of emergence refers to grabbing the inherently fragmented and noisy information that abounds in complex eco-systems, configuring information bits into potential solutions