Where do Trypanosoma cruzi go? The distribution of parasites in blood components from fractionated infected whole blood

Abstract

The highest parasite concentration was detected in the BC, followed by RBCs before leukoreduction. There is a notable risk of transfusion-transmitted Chagas disease associated with nonleukoreduced RBCs. Leukoreduction may be an effective prevention strategy for transfusion-transmitted T. cruzi infection, especially in endemic countries and in nonendemic countries with a high rate of immigration from Latin America.

Our experience in riboflavin and ultraviolet light pathogen reduction technology for platelets: from platelet production to patient care

“…16 We found that the highest T. cruzi concentration in experimentally infected WB units was in the buffy coat fraction, which would explain the high risk of Chagas disease transmission associated with PLT transfusions described in the literature. 17 The prevention of Chagas disease transfusion transmission was most effective when the PRT was applied to PLTs obtained either from apheresis or buffy coats as opposed to other blood components.…”

Leucoreduction for preventing parasite transfusion‐transmission: an overlooked strategy

“…Our research group clearly demonstrated the efficacy of RBC leucoreduction filters in the prevention of Leishmania transfusion-transmission, determining the Leishmania parasitemia load by PCR before and after filtration in RBC units collected from asymptomatic L. infantum-infected blood donors [1]. We have also shown that RBC and WB leucoreduction by filtration reduces T. cruzi concentrations by 99% and consequently can potentially decrease Chagas disease transfusion-transmission risk [2,3]. Moreover, Cardo et al [4] have reported the adherence of malaria-infected RBC to WB filters by at least three different mechanisms, suggesting that the unexplained decline in the incidence of transfusion-transmitted malaria in the last decades could be due to the increasing use of leucoreduction filters.…”

Chagasen gaixotasuna Europan, endemikoa ez izan arren kontuan hartzekoa

“…Odolaren osagaiei dagokienez, parasito-karga handiena plaketen kontzentratuetan behatzen da, eta bigarren kontzentrazio altuena globulu gorrien prestakinetan [32,45], baina azken hauetan filtraziozko leukomurrizketak T. cruzi-ren infekzioaren arriskua ia guztiz deuseztatzen du.…”