Where does indolylacrylic acid come from

Marklová, E

doi:10.1007/bf01361665

Cited by 30 publications

(25 citation statements)

References 11 publications

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“…The formation of IAG is possibly the result of another less-investigated pathway. It is likely that intestinal micro-organisms catabolise tryptophan to indole derivatives which are then absorbed and converted to indolylacrylic acid (IAcrA) and after conjugation of IAcrA with glycine in the liver IAG is formed (58) . Shattock et al (59) hypothesised that IAG represents the detoxified version of a acidic precursor that affects membranes throughout the body, particularly those lining the gut wall and the blood -brain barrier, making them permeable to other biologically active products such as peptides.…”

Section: Indolylacryloylglycinementioning

confidence: 99%

Autism and nutrition: the role of the gut–brain axis

2014

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Autism spectrum disorder (ASD) is characterised by deficits in the ability to socialise, communicate and use imagination, and displays of stereotypical behaviour. It is widely accepted that ASD involves a disorder in brain development. However, the real causes of the neurodevelopmental disorders associated with ASD are not clear. In this respect, it has been found that a majority of children with ASD display gastrointestinal symptoms, and an increased intestinal permeability. Moreover, large differences in microbiotic composition between ASD patients and controls have been reported. Therefore, nutrition-related factors have been hypothesised to play a causal role in the aetiology of ASD and its symptoms. Through a review of the literature, it was found that abnormalities in carbohydrate digestion and absorption could explain some of the gastrointestinal problems observed in a subset of ASD patients, although their role in the neurological and behavioural problems remains uncertain. In addition, the relationship between an improved gut health and a reduction of symptoms in some patients was evaluated. Recent trials involving gluten-free diets, casein-free diets, and pre-and probiotic, and multivitamin supplementation show contradictive but promising results. It can be concluded that nutrition and other environmental influences might trigger an unstable base of genetic predisposition, which may lead to the development of autism, at least in a subset of ASD patients. Clear directions for further research to improve diagnosis and treatment for the different subsets of the disorder are provided.

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Section: Indolylacryloylglycinementioning

confidence: 99%

Autism and nutrition: the role of the gut–brain axis

2014

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“…Porphobilinogen is found in large amounts in the urine of AIP patients due to hepatic overproduction and high excretion of both heme precursors, PBG and ALA. Conversely, IAG is a regular constituent of human urine although its origin is not completely understood . It is generally assumed that bacterial activity in the intestine could be a main source of IAG in human urine.…”

Section: Resultsmentioning

confidence: 99%

Mass spectrometric characterisation of a condensation product between porphobilinogen and indolyl‐3‐acryloylglycine in urine of patients with acute intermittent porphyria

et al. 2015

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Registro de acceso restringido Este recurso no está disponible en acceso abierto por política de la editorial. No obstante, se puede acceder al texto completo desde la Universitat Jaume I o si el usuario cuenta con suscripción. Registre d'accés restringit Aquest recurs no està disponible en accés obert per política de l'editorial. No obstant això, es pot accedir al text complet des de la Universitat Jaume I o si l'usuari compta amb subscripció. Restricted access item This item isn't open access because of publisher's policy. The full--text version is only available from Jaume I University or if the user has a running suscription to the publisher's contents.

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“…However, it has been established that its levels fluctuate in human urine according to the time of year and higher levels may relate to increased exposure to UV light. In this respect it is analogous to urocanic acid which is produced from histidine in response to UV radiation [39].…”

Section: Resultsmentioning

confidence: 99%

Application of Holistic Liquid Chromatography-High Resolution Mass Spectrometry Based Urinary Metabolomics for Prostate Cancer Detection and Biomarker Discovery

et al. 2013

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Human exhibit wide variations in their metabolic profiles because of differences in genetic factors, diet and lifestyle. Therefore in order to detect metabolic differences between individuals robust analytical methods are required. A protocol was produced based on the use of Liquid Chromatography- High Resolution Mass Spectrometry (LC-HRMS) in combination with orthogonal Hydrophilic Interaction (HILIC) and Reversed Phase (RP) liquid chromatography methods for the analysis of the urinary metabolome, which was then evaluated as a diagnostic tool for prostate cancer (a common but highly heterogeneous condition). The LC-HRMS method was found to be robust and exhibited excellent repeatability for retention times (<±1%), and mass accuracy (<±1 ppm). Based on normalised data (against creatinine levels, osmolality or MS total useful signals/MSTUS) coupled with supervised multivariate analysis using Orthogonal Partial Least Square-Discriminant Analysis (OPLS-DA), we were able to discriminate urine samples from men with or without prostate cancer with R2Y(cum) >0.9. In addition, using the receiver operator characteristics (ROC) test, the area under curve (AUC) for the combination of the four best characterised biomarker compounds was 0.896. The four biomarker compounds were also found to differ significantly (P<0.05) between an independent patient cohort and controls. This is the first time such a rigorous test has been applied to this type of model. If validated, the established protocol provides a robust approach with a potentially wide application to metabolite profiling of human biofluids in health and disease.

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Where does indolylacrylic acid come from

Cited by 30 publications

References 11 publications

Autism and nutrition: the role of the gut–brain axis

Autism and nutrition: the role of the gut–brain axis

Mass spectrometric characterisation of a condensation product between porphobilinogen and indolyl‐3‐acryloylglycine in urine of patients with acute intermittent porphyria

Application of Holistic Liquid Chromatography-High Resolution Mass Spectrometry Based Urinary Metabolomics for Prostate Cancer Detection and Biomarker Discovery

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