Teotihuacan in the northeastern Basin of Mexico was an unusually large and influential early city and state. This article reviews recent research trends in Teotihuacan from its founding and explosive growth ca. 100 BC into the largest city in Mesoamerica. Biogenetics provide details of how immigration fueled the city's growth and shaped its multiethnic composition and link Teotihuacan to other parts of the central highlands and more distant regions. Urban theory highlights the importance of neighborhoods and how their composition changed. Collective aspects of irrigation, markets, warfare and the military, and ideology encouraged the development of Teotihuacan's corporate governance. Although Teotihuacan politically dominated central Mexico, its control over the regional economy was not as centralized. Beyond its hinterland, Teotihuacan's foreign relations were a mosaic of trade diasporas, diplomatic exchanges, pilgrimages, emulation, and strategic direct interventions of limited duration. As its foreign influence retracted, Teotihuacan faced challenges from its hinterlands and intermediate elites and factions that culminated in the burning and desecration of the urban center. The Epiclassic saw the change from Teotihuacan's regional state to city-states and confederations. Although much reduced in size, Postclassic Teotihuacan retained an enormous legacy that subsequent states sought for their historical validation.