Where frailty meets diabetes

Perkisas, Stany; Vandewoude, M.

doi:10.1002/dmrr.2743

Cited by 88 publications

(108 citation statements)

References 93 publications

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“…Although investigations into T2DM pathophysiology commonly focus on insulin resistance, and impaired insulin secretion, recent data suggest a broader range of causes. Since T2DM has begun to be considered as a model of “accelerated aging” [39, 40], LTL shortening has been hypothesized to be indicative of senescent cell accumulation and of an increased burden of systemic inflammation [41]. Although inflammation has been suggested to have a key role in T2DM development and progression, its molecular bases are still being investigated [42–44].…”

Section: Discussionmentioning

confidence: 99%

Leukocyte telomere length and mortality risk in patients with type 2 diabetes

et al. 2016

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Leukocyte telomere length (LTL) shortening is found in a number of age-related diseases, including type 2 diabetes (T2DM). In this study its possible association with mortality was analyzed in a sample of 568 T2DM patients (mean age 65.9 ± 9 years), who were followed for a median of 10.2 years (interquartile range 2.2). A number of demographic, laboratory and clinical parameters determined at baseline were evaluated as mortality risk factors. LTL was measured by quantitative real-time PCR and reported as T/S (telomere-to-single copy gene ratio). Age, gender, creatinine, diabetes duration at baseline, and LTL were significantly different between T2DM patients who were dead and alive at follow-up. In the Cox regression analysis adjusted for the confounding variables, shorter LTL, older age, and longer disease duration significantly increased the risk of all-cause mortality (HR = 3.45, 95%CI 1.02-12.5, p = 0.004). Kaplan-Maier analysis also found a different cumulative mortality risk for patients having an LTL shorter than the median (T/S ≤0.04) and disease duration longer than the median (>10 years) (log-rank = 11.02, p = 0.011). Time-dependent mortality risk stratification showed that T2DM duration and LTL combined was a fairly good predictor of mortality over the first 76 months of follow-up.In conclusion, LTL combined with clinical parameters can provide additive prognostic information on mortality risk in T2DM patients.

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Section: Discussionmentioning

confidence: 99%

Leukocyte telomere length and mortality risk in patients with type 2 diabetes

et al. 2016

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“…When screened for in a population of people with DM, the prevalence of frailty also varied and was reported to be between 5-48% [31]. Several studies have shown that older DM patients were more likely to be frail than their non-DM counterparts [19][20][21][32][33][34][35].…”

Section: Prevalence Of Frailtymentioning

confidence: 99%

Frailty in elderly diabetes patients

Yanase

Yanagita

Muta³

et al. 2018

Endocr J

139

104

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Abstract. Frailty is a state of vulnerability and a consequence of cumulative decline in multiple physiological systems over a lifespan. The occurrence of frailty depends on deterioration in muscle and nerve function, declining cardiopulmonary reserve and loss of executive function. Diabetes mellitus (DM) often causes functional impairment in each of the above systems, thus leading to a loss of whole body homeostasis and deterioration in physical function. Inability of self-management in DM patients may also have considerable impact on the development of sarcopenia/frailty. Thus, there may be positive feedback between the progression of diabetic complications and frailty/sarcopenia. While various factors are involved in this process, insulin resistance or insulin depletion may be an important factor in the progression of frailty in diabetes patients since insulin is well known to be an anabolic hormone in muscle. Interestingly, in our study targeting elderly DM patients, low HbA1c was a significant and independent risk factor for frailty, as assessed using a broad sense frailty scale, the Clinical Frailty Scale (CSF), suggesting that reverse metabolism due to malnutrition in elderly type 2 DM patients might be involved. Therefore, an intervention that includes proper nutrition and exercise training may be essential for the prevention of frailty. The pathogenesis of frailty in DM patients is extensively discussed in this review.

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“…Sarcopenia, particularly for type II fibers is a hallmark of inactivity and aging (14, 44, 58). Indeed the development of comorbidities such as kidney disease, atherosclerosis, and diabetes, which may contribute to accelerated sarcopenia, are not uncommon as the population ages (14, 44).…”

Section: Discussionmentioning

confidence: 99%

Effects of Short-Term Free-Weight and Semiblock Periodization Resistance Training on Metabolic Syndrome

South

Layne

Stuart

et al. 2016

Journal of Strength and Conditioning Research

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The effects of short-term resistance training on performance and health variables associated with prolonged sedentary lifestyle and metabolic syndrome were investigated. Resistance training may alter a number of health-related, physiological and performance variables. As a result, resistance training can be used as a valuable tool in ameliorating the effects of a sedentary lifestyle including those associated with metabolic syndrome. Nineteen previously sedentary subjects (10 metabolic syndrome, 9 non-metabolic syndrome) underwent 8 weeks of supervised resistance training. Maximum strength was measured using an isometric mid-thigh pull and resulting force-time curve. Vertical jump height and power were measured using a force plate. Muscle cross-sectional area (CSA) and type were examined using muscle biopsy and standard analysis techniques. Aerobic power was measured on a cycle ergometer using a ParvoMedics 2400 Metabolic system. Endurance was measured as time to exhaustion on a cycle ergometer. After training, maximum isometric strength, jump height, jump power and V̇O2 peak increased by approximately 10% (or more) in both the metabolic and non-metabolic syndrome groups (both male and female subjects). Over 8 weeks of training, body mass did not change statistically, but percent body fat decreased in subjects with the metabolic syndrome and in females, and lean body mass increased in all groups (p<0.05). Few alterations were noted in fiber type. Males had larger CSA’s compared to females and there was a fiber-specific trend toward hypertrophy over time. In summary eight weeks of semi-block free-weight resistance training improved several performance variables and some cardiovascular factors associated with metabolic syndrome.

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Where frailty meets diabetes

Cited by 88 publications

References 93 publications

Leukocyte telomere length and mortality risk in patients with type 2 diabetes

Leukocyte telomere length and mortality risk in patients with type 2 diabetes

Frailty in elderly diabetes patients

Effects of Short-Term Free-Weight and Semiblock Periodization Resistance Training on Metabolic Syndrome

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