Abstract:IsPETase displayed great potential for mitigating PET contamination under moderate temperatures attributed to its specific high activity towards PET, while rapid activity loss limited its commercial viability. Herein, a thermostable S92P/D157A variant (Tm=70.8 °C) was constructed, enabling a 109.3-fold increase in products released from amorphous PET depolymerization at 40 °C. Further depolymerization of untreated post-consumer PET in a 360-times expanded reaction system obtained 20.09 mM products (95.0% TPA).… Show more
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