Whey peptide-based enteral diet attenuated elastase-induced emphysema with increase in short chain fatty acids in mice

Tomoda, Koichi; Kubo, Kaoru; Dairiki, Kazuo; Yamaji, Taketo; Yamamoto, Yoshihiko; Nishii, Yasue; Nakamura, Atsuhiro; Yoshikawa, Masayuki; Hamada, Kaoru; Kimura, Hiroshi

doi:10.1186/s12890-015-0059-2

Cited by 28 publications

(17 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our ndings suggest that the decrease in SCFA levels observed following exposure to BMF or MVE. Animal experiments also support this SCFA-related mechanism; an increase in dietary SCFAs was reported to attenuate the development of smoking-related emphysema in rats and mice [38,39]. We propose that SCFAs, and especially acetic acid, may confer a protective effect against PM-induced COPD.…”

Section: Discussionsupporting

confidence: 58%

Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model

Yang

Liao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The role of the gut microbiota in the pathogenesis of chronic obstructive pulmonary disease following exposure to ambient particulate matter is largely unknown. We hypothesized that exposure alters gut microbial composition and metabolites and may involved in the pathogenesis of chronic obstructive pulmonary disease.Methods: Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel, or motor vehicle exhaust for 4, 12, and 24 weeks. Lung tissue was assessed histologically and gut microbial composition was assessed by 16S rRNA pyrosequencing. Serum lipopolysaccharide levels were measured and short-chain fatty acids in colon contents were quantified. Results: After a 24-week exposure to particulate matter, rats exhibited pulmonary inflammation and pathological changes characteristic of chronic obstructive pulmonary disease. The gut microbiome was characterized by decreased microbial richness and diversity, distinct overall microbial composition, lower levels of short-chain fatty acids, and higher serum lipopolysaccharide. Conclusion: Chronic exposure to ambient particulate matter induces gut microbial dysbiosis and metabolite shifts in a rat model of chronic obstructive pulmonary disease.

show abstract

Section: Discussionsupporting

confidence: 58%

Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model

Yang

Liao

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Oral Lactobacillus casei administration improved the previously defective function of peripheral natural killer cells in adult male smokers 91 , whereas Bifidobacterium breve and Lactobacillus rhamnosus reduced lung pathology in a mouse model of COPD 92 , and reduced inflammatory responses in macrophages exposed to cigarette smoke extract in vitro 93 . Similarly, a diet which increased SCFA production protected against elastase-induced inflammation and emphysema 94 .…”

Section: [H3] Microbiota and Copdmentioning

confidence: 97%

Emerging pathogenic links between microbiota and the gut–lung axis

et al. 2016

View full text Add to dashboard Cite

The microbiota is vital for the development of the immune system and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the respiratory tract and the gut have recently been linked to alterations in immune responses and to disease development in the lungs. In this Opinion article, we review the microbial species that are usually found in healthy gastrointestinal and respiratory tracts, their dysbiosis in disease and interactions with the gut-lung axis. Although the gut-lung axis is only beginning to be understood, emerging evidence indicates that there is potential for manipulation of the gut microbiota in the treatment of lung diseases.

show abstract

“…142 Furthermore, mice fed a peptide-based enteral diet that increased the production of SCFAs attenuated elastase-induced inflammation and emphysema in the lung. 143 The axis is by no means onedirectional, with respiratory infection driving perturbations in the gut microbiome, but further work is needed to validate this. 144,145 A study reported that the intranasal delivery of a non-absorbable tracer into the nasal cavity of mice appeared in the gastrointestinal tract shortly after.…”

Section: The Gutàlung Axismentioning

confidence: 99%

Respiratory microbiome and epithelial interactions shape immunity in the lungs

2020

View full text Add to dashboard Cite

OTHER ARTICLES PUBLISHED IN THIS REVIEW SERIES Immunological fortification at our barrier organs: Protecting us as we age. Immunology 2020, 160: 103-105. Immune responses in the human female reproductive tract. Immunology 2020, 160: 106-155. Skin barrier immunity and ageing. Immunology 2020, 160: 116-125. Origin and ontogeny of lung macrophages: from mice to humans. Immunology 2020, 160: 126-138. Regulation of barrier immunity and homeostasis by integrin-mediated transforming growth factor b activation. Immunology 2020, 160: 139-148. The developing immune network in human prenatal skin. Immunology 2020, 160: 149-156. The liver as an immunological barrier redefined by single-cell analysis. Immunology 2020, 160: 157-170.

show abstract

Whey peptide-based enteral diet attenuated elastase-induced emphysema with increase in short chain fatty acids in mice

Cited by 28 publications

References 19 publications

Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model

Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model

Emerging pathogenic links between microbiota and the gut–lung axis

Respiratory microbiome and epithelial interactions shape immunity in the lungs

Contact Info

Product

Resources

About