Whey valorization for sustainable polyhydroxyalkanoate production by Bacillus megaterium: Production, characterization and in vitro biocompatibility evaluation

Israni, Neetu; Venkatachalam, Prerana; Gajaraj, B.; Varalakshmi, Kilingar Nadumane; Shivakumar, Srividya

doi:10.1016/j.jenvman.2019.109884

Cited by 78 publications

(18 citation statements)

References 45 publications

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“…Among the most popular and effective tools to know the optimal parameters of a process is the response surface methodology, frequently associated with development of new products [44][45][46] and processes [47,48], the maximization of the productivity or yield of the process products [49][50][51][52], the reduction of their Design of experiments for enhanced production of bioactive exopolysaccharides from indigenous probiotic lactic acid bacteria.…”

Section: Agroindustry: a Suitable Receptor For The Use Of The Response Surface Methodology (Rsm)mentioning

confidence: 99%

Uses of the Response Surface Methodology for the Optimization of Agro-Industrial Processes

Pais-Chanfrau¹,

Núñez-Pérez²,

Espín-Valladares³

et al. 2021

Response Surface Methodology in Engineering Science

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Response surface methodology is a tool for the design of experiments, widely used today to optimize industrial processes, including agro-industrial ones. Since its appearance in the last century’s fifties, hundreds of articles, chapters of books, and books attest to this. In this work, a general overview of this tool’s general practical aspects is made. This statistical tool’s usefulness and popularity, used in the optimization of agro-industrial processes and in making them more efficient and sustainable, is described through multiple examples.

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Section: Agroindustry: a Suitable Receptor For The Use Of The Response Surface Methodology (Rsm)mentioning

confidence: 99%

Uses of the Response Surface Methodology for the Optimization of Agro-Industrial Processes

Pais-Chanfrau¹,

Núñez-Pérez²,

Espín-Valladares³

et al. 2021

Response Surface Methodology in Engineering Science

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“…Whey-based microbial growth media can be achieved through different levels of processing. Whole/crude whey is nonsterile, but has been successfully utilized as microbial media (Dessì et al., 2020 ; Israni et al., 2020 ; Mano et al., 2020 ). Whey powder, generated through spray drying, can be diluted in water to produce a medium with greater ability to control lactose concentration, albeit with higher production costs (Amaro et al., 2019 ; Zikmanis et al., 2020 ).…”

Section: Carbohydrate-rich Food Wastesmentioning

confidence: 99%

“…To enable direct conversion of lactose, the primary sugar in whey, it is preferable to utilize organisms with β-galactosidase activity as this bypasses the need for additional pretreatment: hydrolysis via chemicals, enzymes, or Lactobacilli (Israni et al., 2020 ). For example, Aureobasidium pullulans (also known as Aureobasidium namibiae ), a yeast-like fungus known to produce industrially relevant enzymes such as galactosidases (Prasongsuk et al., 2018 ), was recently studied for lipid production from whey powder medium (Wang, Ye, et al., 2021 ).…”

Section: Carbohydrate-rich Food Wastesmentioning

confidence: 99%

Microbial valorization of underutilized and nonconventional waste streams

Lad

Coleman

Alper

2021

Journal of Industrial Microbiology and Biotechnology

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The growing burden of waste disposal coupled with natural resource scarcity has renewed interest in the remediation, valorization and/or repurposing of waste. Traditional approaches such as composting, anaerobic digestion, use in fertilizers or animal feed, or incineration for energy production extract very little value out of these waste streams. In contrast, waste valorization into fuels and other biochemicals via microbial fermentation is an area of growing interest. In this review, we discuss microbial valorization of nonconventional, aqueous waste streams such as food processing effluents, wastewater streams, and other industrial wastes. We categorize these waste streams as carbohydrate-rich food wastes, lipid-rich wastes, and other industrial wastes. Recent advances in microbial valorization of these nonconventional waste streams are highlighted, along with a discussion of the specific challenges and opportunities associated with impurities, nitrogen content, toxicity, and low productivity.

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“…[ 97 ] Bacillus megaterium has been shown to produce 2.20 ± 0.11 g L −1 of PHA with PHA productivity of 0.05 g L −1 h −1 of using whey. [ 98 ] B. megaterium CCM 2037 could produce PHB of 1.05 g L −1 with whey as substrate, which was increased by 40% with the addition of 1% ethanol. [ 99 ] Thermus thermophilus HB8 produced PHA of 35% ( w/w ) by the biomass utilizing 24% ( v/v ) whey.…”

Section: Use Of Conventional and Non‐conventional Substratementioning

confidence: 99%

Process optimization, metabolic engineering interventions and commercialization of microbial polyhydroxyalkanoates production – A state‐of‐the art review

Lhamo

Behera

Mahanty

2021

Biotechnology Journal

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Background Microbial polyhydroxyalkanoates (PHAs) produced using renewable resources could be the best alternative for conventional plastics. Despite their incredible potential, commercial production of PHAs remains very low. Nevertheless, sincere attempts have been made by researchers to improve the yield and economic viability of PHA production by utilizing low‐cost agricultural or industrial wastes. In this context, the use of efficient microbial culture or consortia, adoption of experimental design to trace ideal growth conditions, nutritional requirements, and intervention of metabolic engineering tools have gained significant attention. Purpose and scope This review has been structured to highlight the important microbial sources for PHA production, use of conventional and non‐conventional substrates, product optimization using experimental design, metabolic engineering strategies, and global players in the commercialization of PHA in the past two decades. The challenges about PHA recovery and analysis have also been discussed which possess indirect hurdle while expanding the horizon of PHA‐based bioplastics. Summary Selection of appropriate microorganism and substrate plays a vital role in improving the productivity and characteristics of PHAs. Experimental design‐based bioprocess, use of metabolic engineering tools, and optimal product recovery techniques are invaluable in this dimension. Conclusion Optimization strategies, which are being explored in isolation, need to be logically integrated for the successful commercialization of microbial PHAs.

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Whey valorization for sustainable polyhydroxyalkanoate production by Bacillus megaterium: Production, characterization and in vitro biocompatibility evaluation

Cited by 78 publications

References 45 publications

Uses of the Response Surface Methodology for the Optimization of Agro-Industrial Processes

Uses of the Response Surface Methodology for the Optimization of Agro-Industrial Processes

Microbial valorization of underutilized and nonconventional waste streams

Process optimization, metabolic engineering interventions and commercialization of microbial polyhydroxyalkanoates production – A state‐of‐the art review

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