Which are the central aspects of infant sleep? The dynamic of sleep composites across infancy

Schoch, Sarah F.; Huber, Reto; Kohler, Malcolm; Kurth, Salomé

doi:10.1101/2020.10.26.354803

Cited by 4 publications

(6 citation statements)

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“…The effect was most substantial at 3 months and gradually decreased thereafter. This finding is exciting because we recently identified Sleep Day also as the most relevant player linked to infant behavioral development among other comprehensively tested sleep behaviors [4]. Yet, why the sleep-gut association weakens across development is unclear.…”

Section: Sleep Sleep Daymentioning

confidence: 98%

“…FIML is a general estimate of missing predictor data, yet not of outcome. We specified the five sleep composites as latent variables using the 32 sleep variables on which the composites are based [4]. For alpha diversity, we specified a latent variable onto which the three different diversity index load.…”

Section: Analysis Of Gut Bacteria Datamentioning

confidence: 99%

“…Sleep regulation undergoes significant maturation in early development, with the most drastic changes in the first year of life. Although sleep behavior is highly variable between infants, universal maturational patterns are visible: in the first year of infancy, a 24-h rhythm emerges, and nighttime sleep is consolidated [3,4]. In the past decade, empirical work has revolutionized our understanding: from sleep as a global behavior towards sleep as a localized neurophysiological and cellular recovery process that interacts with neurodevelopment [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…We hypothesized that more mature sleep-wake behavior patterns are linked to more mature infant gut bacteria profiles, the latter represented by the three measures: gut bacterial diversity, bacterial maturation index, and the assignment to enterotypes. experienced no antibiotic intake in their first three months of life (for detailed inclusion and exclusion criteria see [4]). Sub-sections of this dataset were published previously [4,61].…”

Section: Introductionmentioning

confidence: 99%

“…experienced no antibiotic intake in their first three months of life (for detailed inclusion and exclusion criteria see [4]). Sub-sections of this dataset were published previously [4,61]. Ethical approval was obtained from the cantonal ethics committee (BASEC 2016-00730), and study procedures were consistent with the declaration of Helsinki.…”

Section: Introductionmentioning

confidence: 99%

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From Alpha Diversity to ZZZ: Exploring associations among sleep, gut bacteria and behavioral development in infancy

Schoch¹,

Castro-Meija²,

Krych³

et al. 2021

Preprint

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Infancy is a period of marked development, entailing many maturation processes that lay the foundation for later health. Two crucial health factors in infancy are the establishment of a sleep-wake rhythm and the growth of gut bacterial diversity - both have been linked to later cognitive and physiological outcomes. In adults and animal models, evidence is emerging that sleep and gut bacteria are bidirectionally linked. However, it is yet unclear when and how the sleep-gut link in early life evolves. Here we demonstrate that a sleep-gut link develops in infancy, undergoes transitional dynamics, and involves an early sensitive period. Specifically, infants' daytime sleep is linked to markers of bacterial diversity, and nighttime awakenings are associated with gut bacterial maturity and bacterial enterotype. Furthermore, both sleep and gut bacteria are associated with behavioral developmental outcomes, with the strongest connections at 3 months of age. Our results demonstrate the dynamic interplay of sleep and gut bacteria within healthy human development. As both sleep and gut bacteria are modifiable, they are promising targets for early intervention in clinical groups.

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Section: Sleep Sleep Daymentioning

confidence: 98%

Section: Analysis Of Gut Bacteria Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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From Alpha Diversity to ZZZ: Exploring associations among sleep, gut bacteria and behavioral development in infancy

Schoch¹,

Castro-Meija²,

Krych³

et al. 2021

Preprint

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Association of Sleep Patterns and Respiratory Disturbance Index with Physiological Parameters in Pediatric Patients with Self-Perceived Short Stature

Huang,

Liao,

Chang

et al. 2024

Diagnostics

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Objective: To investigate the relationships of sleep patterns and respiratory disturbance index (RDI) with key physiological parameters (height, body mass index (BMI), bone age (BA), and IGF-1 levels) in children aged 6 to 16 years with self-perceived short stature. Methods: For this cross-sectional study, conducted from October 2019 to November 2021, 238 children aged 6 to 16 years with self-perceived short stature were enrolled. The primary outcomes of sleep patterns and the RDI were non-invasively collected at home using the LARGAN Health AI-Tech Sleep Apnea and Sleep Quality Examination System, which operates based on polygraphy. Additionally, various physiological parameters, including height, BMI, bone age, and IGF-1 levels, were measured to assess their associations with sleep patterns and RDI. Results: Significant age-related reductions were observed in both the total and deep sleep durations. Children aged 6–9 years averaged 8.5 ± 1.0 h of total sleep, which decreased to 8.1 ± 1.1 h in ages 10–11 and further to 7.5 ± 0.9 h in ages 12–16 (p < 0.0001). Deep sleep followed a similar pattern, decreasing from 4.4 ± 1.1 h in the youngest group to 3.3 ± 1.0 h in the oldest (p < 0.0001). Notably, girls experienced significantly longer deep sleep than boys, averaging 4.0 ± 1.2 h compared to 3.6 ± 1.2 h (p = 0.0153). In a multivariable regression analysis, age (beta = 4.89, p < 0.0001) and RDI (beta = −0.54, p = 0.0022) were significantly associated with body height. Age and deep sleep duration (beta = −0.02, p = 0.0371) were significantly associated with BMI. Conclusions: The results demonstrate significant age-related decreases in the total and deep sleep duration among children with self-perceived short stature, along with a notable association between RDI and body height and an association between deep sleep duration and BMI. These findings suggest that sleep disturbances in pediatric endocrine patients are intricately linked with physiological growth parameters. The identified correlations underline the importance of monitoring sleep patterns in this demographic to better understand the impact of endocrine disorders on developmental health. Further research is needed to explore interventions that could alleviate these sleep disturbances, thereby potentially improving outcomes for the affected children.

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Infant Care: Predictors of Outdoor Walking, Infant Carrying and Infant Outdoor Sleeping

Rheinheimer,

Vacaru,

van Immerseel

et al. 2024

IJERPH

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Background. Although spending time outdoors is beneficial for development, little is known about outdoor time during infancy. The aim of this study was to assess frequencies and durations of (1a) outdoor walking and carrying in mother–infant dyads and (1b) infant outdoor sleeping in a stationary cot or pram. We furthermore aimed to identify associations of (2a) outdoor walking and carrying and (2b) infant outdoor sleeping, with infant, maternal and environmental sample characteristics. Methods. An online survey was distributed among mothers of 0- to 12-month-old infants. Initially, 1453 mothers were recruited, of which 1275 were included in the analyses. With respect to (1a) the outcomes of interest were: mother–infant dyads’ total weekly duration of walking in minutes, frequency of walking on weekdays, as well as weekends, and the frequency of using an infant carrier during walks, as well as the daily duration of carrying in hours (indoors and outdoors together). With respect to (1b) the outcome variables were: placing the infant outdoors to sleep (yes/no), the total weekly duration of outdoor sleeping and the weekly frequency of outdoor sleeping. For aim 2, associations of the outcome variables with infant (i.e., age), maternal (i.e., working status) and environmental (i.e., house type) sample characteristics were assessed. Results. Mother–infant dyads engaged in walks for a total weekly duration of 201 min, for approximately one to three walks over weekdays (Monday through Friday), as well as one to three walks on the weekend. The infant carrier was used by 22% of mothers at least half of the time during outdoor walks, and 18% reported a daily duration of infant carrying of one hour or more. Among other associations, infant and maternal enjoyment of outdoor walking correlated positively with the duration as well as the frequency of walking during weekdays and during the weekend. Furthermore, employed mothers walked for a shorter duration and less frequently on weekdays as compared to mothers on maternity leave or mothers without a paid job. The availability of nearby recreational areas correlated positively with the weekly duration and frequency of walks. The infant carrier was used more frequently during outdoor walks if more than one child lived in the household. Infant carrying during outdoor walks was also related to infant behavior at night. Roughly a third of the mothers (29%) regularly had their infant sleep outdoors for a weekly duration of four hours and a weekly frequency of approximately one to two times. Younger infants, infants of mothers with higher education and infants living in detached houses were more likely to be placed outdoors to sleep. Discussion. We identified associations of infant, maternal and environmental characteristics with outdoor time spent during infancy. These results lay the foundation for future research on the effects of the outdoors on child development as well as on facilitators and barriers for caregivers.

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Which are the central aspects of infant sleep? The dynamic of sleep composites across infancy

Cited by 4 publications

References 64 publications

From Alpha Diversity to ZZZ: Exploring associations among sleep, gut bacteria and behavioral development in infancy

From Alpha Diversity to ZZZ: Exploring associations among sleep, gut bacteria and behavioral development in infancy

Association of Sleep Patterns and Respiratory Disturbance Index with Physiological Parameters in Pediatric Patients with Self-Perceived Short Stature

Infant Care: Predictors of Outdoor Walking, Infant Carrying and Infant Outdoor Sleeping

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