Which Biopsy Method Is More Suitable Between a Basin Dissection and Pick-Up Biopsy for Sentinel Nodes in Laparoscopic Sentinel-Node Navigation Surgery (LSNNS) for Gastric Cancer?

Lee, Young-Joon; Ha, Woo-Song; Park, Soon-Tae; Choi, Sang-Kyung; Hong, Soon-Chan; Park, Jung‐Woo

doi:10.1089/lap.2007.0024

Cited by 48 publications

(50 citation statements)

References 15 publications

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“…For the studies utilizing 99m Tc-sulfur colloid, the FNR was 11.4% (95% CI -1.7, 24.6) (forest plot not shown). Five studies [1,17,23,27,35] used DUAL to identify the SLN. A total of 298 patients underwent SLN identification by this method (with a range of 31-92 patients per study).…”

Section: Results By Sln Identification Methodsmentioning

confidence: 99%

“…A total of 298 patients underwent SLN identification by this method (with a range of 31-92 patients per study). Three studies used 1-1.2 mL of patent blue [1,17,23]; one study used 1 mL of isosulfan blue [27]; and one study used 2 mL of ICG [35]. Four studies used 2 mL of 99m Tc-tin colloid [1,23,27,35] and one study used 0.4 mL of 99m Tc-sulfur colloid [17].…”

Section: Results By Sln Identification Methodsmentioning

confidence: 99%

“…Three studies used 1-1.2 mL of patent blue [1,17,23]; one study used 1 mL of isosulfan blue [27]; and one study used 2 mL of ICG [35]. Four studies used 2 mL of 99m Tc-tin colloid [1,23,27,35] and one study used 0.4 mL of 99m Tc-sulfur colloid [17]. In all studies, the radiocolloid was endoscopically injected into the submucosa at 4 points adjacent to the tumor 16-18 h preoperatively, and the dye was endoscopically injected into the submucosa at 4 points adjacent to the tumor at laparotomy.…”

Section: Results By Sln Identification Methodsmentioning

confidence: 99%

“…In all studies, the radiocolloid was endoscopically injected into the submucosa at 4 points adjacent to the tumor 16-18 h preoperatively, and the dye was endoscopically injected into the submucosa at 4 points adjacent to the tumor at laparotomy. One study used H&E only [1], and 4 studies used H&E and IHC [17,23,27,35]. The detection rate for DUAL ranged from 54.8 to 100%.…”

Section: Results By Sln Identification Methodsmentioning

confidence: 99%

“…Other groups that examined submucosal injection of dye reported FNRs of 0-40.0% (calculated FNRs of 0-66.7%). One study examined the difference between a pick-up method (where only stained and/or radioactive nodes were removed) and a basin dissection method (the entire LN basin was removed if stained and/or if radioactive nodes were present) [35]. The detection rate for the pick-up method was much poorer (54.8 vs. 96.0%), as were the calculated FNRs (50.0%, 95% CI 6.8, 93.2, and 16.7%, 95% CI -15.1, 48.4), suggesting that removal of entire nodal basins can significantly decrease the FNR rate.…”

Section: Implications Of the False-negative Ratementioning

confidence: 99%

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What is the accuracy of sentinel lymph node biopsy for gastric cancer? A systematic review

et al. 2012

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Background In gastric cancer, the utility of sentinel lymph node (SLN) biopsy has not been established. SLN may be a good predictor of the pathological status of other lymph nodes and thus the necessity for more extensive surgery or lymph node dissection. We aimed to identify and synthesize findings on the performance of SLN biopsies in gastric cancer. Methods Electronic literature searches were conducted using Medline, EMBASE, and the Cochrane Central Register of Controlled Trials from 1998 to 2009. Titles and abstracts were independently rated for relevance by a minimum of two reviewers. Techniques, detection rates, accuracy, sensitivity, specificity, and false-negative rates (FNRs) were analyzed. Analysis was performed based on the FNR. Results Twenty-six articles met our inclusion criteria. SLN detection using the dye method (DM) was reviewed in 18 studies, the radiocolloid method (RM) was used in 12 studies, and both dye and radiocolloid methods (DUAL) were used in 5 studies. The DM had an overall calculated FNR of 34.7% (95% confidence interval [CI] 21.2, 48.1). The RM had an overall calculated FNR of 18.5% (95% CI 9.1, 28.0). DUAL had an overall calculated FNR of 13.1% (95% CI -0.9, 27.2). Conclusion Application of the SLN technique may be practical for early gastric cancer. The use of DUAL for identifying SLN may yield a lower FNR than either method alone, although statistical significance was not met.

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Section: Results By Sln Identification Methodsmentioning

confidence: 99%

Section: Results By Sln Identification Methodsmentioning

confidence: 99%

Section: Results By Sln Identification Methodsmentioning

confidence: 99%

Section: Results By Sln Identification Methodsmentioning

confidence: 99%

Section: Implications Of the False-negative Ratementioning

confidence: 99%

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What is the accuracy of sentinel lymph node biopsy for gastric cancer? A systematic review

et al. 2012

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Laparoscopic sentinel node navigation surgery versus laparoscopic gastrectomy with lymph node dissection for early gastric cancer: short-term outcomes of a multicentre randomized controlled trial (SENORITA)

Min

Hur

et al. 2020

British Journal of Surgery

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Background Sentinel node navigation surgery reduces the extent of gastric and lymph node dissection, and may improve quality of life. The benefit and harm of laparoscopic sentinel node navigation surgery (LSNNS) for early gastric cancer is unknown. The SENORITA (SEntinel Node ORIented Tailored Approach) trial investigated the pathological and surgical outcomes of LSNNS compared with laparoscopic standard gastrectomy (LSG) with lymph node dissection. Methods The SENORITA trial was an investigator‐initiated, open‐label, parallel‐assigned, non‐inferiority, multicentre RCT conducted in Korea. The primary endpoint was 3‐year disease‐free survival. The secondary endpoints, morbidity and mortality within 30 days of surgery, are reported in the present study. Results A total of 580 patients were randomized to LSG (292) or LSNNS (288). Surgery was undertaken in 527 patients (LSG 269, LSNNS 258). LSNNS could be performed according to the protocol in 245 of 258 patients, and a sentinel node basin was detected in 237 (96·7 per cent) Stomach‐preserving surgery was carried out in 210 of 258 patients (81·4 per cent). Postoperative complications occurred in 51 patients in the LSG group (19·0 per cent) and 40 (15·5 per cent) in the LSNNS group (P = 0·294). Complications with a Clavien–Dindo grade of III or higher occurred in 16 (5·9 per cent) and 13 (5·0 per cent) patients in the LSG and LSNNS groups respectively (P = 0·647). Conclusion The rate and severity of complications following LSNNS for early gastric cancer are comparable to those after LSG with lymph node dissection. Registration number: NCT01804998 ( http://www.clinicaltrials.gov).

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Is the sentinel node biopsy clinically applicable for limited lymphadenectomy and modified gastric resection in gastric cancer? A meta‐analysis of feasibility studies

Ryu

Nam

Lee

et al. 2011

Journal of Surgical Oncology

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Which Biopsy Method Is More Suitable Between a Basin Dissection and Pick-Up Biopsy for Sentinel Nodes in Laparoscopic Sentinel-Node Navigation Surgery (LSNNS) for Gastric Cancer?

Cited by 48 publications

References 15 publications

What is the accuracy of sentinel lymph node biopsy for gastric cancer? A systematic review

What is the accuracy of sentinel lymph node biopsy for gastric cancer? A systematic review

Laparoscopic sentinel node navigation surgery versus laparoscopic gastrectomy with lymph node dissection for early gastric cancer: short-term outcomes of a multicentre randomized controlled trial (SENORITA)

Is the sentinel node biopsy clinically applicable for limited lymphadenectomy and modified gastric resection in gastric cancer? A meta‐analysis of feasibility studies

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