Which circulating level of 25-hydroxyvitamin D is appropriate?

Lips, Paul

doi:10.1016/j.jsbmb.2004.03.040

Cited by 306 publications

(279 citation statements)

References 26 publications

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“…However, the slope of the regression line between plasma PTH and 25-hydroxyvitamin D below 52 nmol/l is significantly different from zero (Po0.003), whereas, above this concentration the slope of regression line does not differ from zero (P ¼ 0.775). Further, our estimate is similar to estimates obtained in other populations and the same as the global estimate for the optimal 25-hydroxyvitamin D concentration of 450 nmol/l suggested by Lips, (2004). Aloia et al, (2006) recently conducted a systematic review that included 31 studies that reported a 25-hydroxyvitamin D threshold for PTH suppression.…”

Section: Vitamin D and Pth In Southeast Asian Women Tj Green Et Alsupporting

confidence: 87%

Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur

et al. 2007

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Objective: To describe the vitamin D status of women living in two Asian cities, -Jakarta (61S) and , to examine the association between plasma 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations, and to determine a threshold for plasma 25-hydroxyvitamin D above which there is no further suppression of PTH. Also, to determine whether dietary calcium intake influences the relationship between PTH and 25-hydroxyvitamin D. Design: Cross-sectional. Setting: Jakarta, Indonesia and Kuala Lumpur, Malaysia. Participants: A convenience sample of 504 non-pregnant women 18-40 years. Main measures: Plasma 25-hydroxyvitamin D and PTH. Results: The mean 25-hydroxyvitamin D concentration was 48 nmol/l. Less than 1% of women had a 25-hydroxyvitamin D concentration indicative of vitamin D deficiency (o17.5 nmol/l); whereas, over 60% of women had a 25-hydroxyvitamin D concentration indicative of insufficiency (o50 nmol/l). We estimate that 52 nmol/l was the threshold concentration for plasma 25-hydroxyvitamin D above which no further suppression of PTH occurred. Below and above this concentration the slopes of the regression lines were À0.18 (different from 0; P ¼ 0.003) and À0.01 (P ¼ 0.775), respectively. The relation between vitamin D status and parathyroid hormone concentration did not differ between women with low, medium or high calcium intakes (P ¼ 0.611); however, even in the highest tertile of calcium intake, mean calcium intake was only 657 mg/d. Conclusion: On the basis of maximal suppression of PTH we estimate an optimal 25-hydroxyvitamin D concentration of B 50 nmol/l. Many women had a 25-hydroxyvitamin D below this concentration and may benefit from improved vitamin D status.

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Section: Vitamin D and Pth In Southeast Asian Women Tj Green Et Alsupporting

confidence: 87%

Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur

et al. 2007

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“…This lower intake may be explained by the age group in the current study and suggest that young adults may have particularly low vitamin D intakes. It is perhaps not surprising, therefore, that we also observed a mean baseline plasma 25(OH)D concentration of 52.1 (17.6) nmol/l, a concentration which indicates a vitamin D status bordering on insufficiency (25(OH)D o50 nmol/l) (Lips, 2004). Our results are comparable with an earlier study conducted among young men living in Boston, (at a latitude of 421N) which reported 25(OH)D levels of 54.4 (16.8) nmol/l during wintertime (Harris and Dawson-Hughes, 2002).…”

Section: Discussionsupporting

confidence: 50%

“…Studies have used various biomarkers to define vitamin D sufficiency, such as changes in PTH concentrations and effects on bone metabolism (Lips et al, 1988;Bates et al, 2003). Plasma 25(OH)D concentrations of o25 (Parfitt, 1998;SACN report, 2003), 30 (Lips et al, 1988) and 50 (Lips, 2004) nmol/l have been suggested as cutoff levels for insufficiency, with the recommendation of o50 nmol/l being widely used in recent studies investigating vitamin D status.…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults

et al. 2006

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Objective: To assess the vitamin D status of healthy young people living in Northern Ireland and the effect of vitamin D supplementation on vitamin D status and bone turnover. Design: Double-blinded randomised controlled intervention study. Setting: University of Ulster, Coleraine, Northern Ireland. Subjects: In total, 30 apparently healthy students (15 male and 15 female subjects), aged 18-27 years, were recruited from the university, with 27 completing the intervention. Interventions: Subjects were randomly assigned, to receive either 15 mg (600 IU) vitamin D 3 and 1500 mg calcium/day (vitamin D group), or 1500 mg calcium/day (control group) for 8 weeks between January and March. Vitamin D status, bone turnover markers, serum calcium and parathyroid hormone concentrations were measured at baseline and post intervention.

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“…Serum 25(OH)D, the major circulating metabolite of vitamin D, was used to assess vitamin D status (Lips, 2004;Holick, 2006). Serum 25(OH)D concentration reflects the total vitamin D from two sources, synthesis from sunlight exposure and dietary intake (Holick, 2006).…”

Section: Serum 25(oh)d and Pth Concentrationsmentioning

confidence: 99%

Assessment of serum 25(OH)D concentration in women of childbearing age and their preschool children in Northern Jordan during summer

Gharaibeh

Stoecker

2009

Eur J Clin Nutr

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Objective: To assess vitamin D status in women and their children aged 4-5 years in Northern Jordan during summer. Design: A cross-sectional study in which 93 mother-child dyads volunteered through local community centers between June and July 2007. Anthropometric measurements were performed and information on socioeconomic status, health issues, lifestyle factors and nutritional intake were obtained from mothers through a questionnaire. Main measures: Serum 25(OH)D and serum parathyroid hormone (PTH) levels were measured. Results: Mean age (s.d.) was 34.0 (6.0) years for mothers and 60.7 (5.4) months for children. Maternal body mass index (BMI) was 29.6 (5.6) kg/m 2 with 77% of women having a BMI X25 kg/m 2 . Mean concentration of serum 25(OH)D was 25.6 (9.6) nmol/l in mothers; only two women (2.2%) had 25(OH)D concentrations o12.5 nmol/l, but 48.9% of women had o25.0 nmol/l, and 97.8% of women had o50 nmol/l. No woman had values above 75 nmol/l. Children had higher (Po0.0001) serum 25(OH)D concentrations than did their mothers with a mean of 55.8 nmol/l. The children also had lower (Po0.0001) mean serum PTH concentrations than did their mothers (1.47 vs 3.12 pmol/l, respectively). Only three children had serum 25(OH)D concentration o25 nmol/l, but 39% (n ¼ 34) had 25(OH)D o50.0 nmol/l. Older women and those with five or more pregnancies had significantly reduced mean serum 25(OH)D concentrations. Children living in families with lower income had significantly higher mean serum 25(OH)D concentration as did children consuming fortified milk compared with those consuming non-fortified milk. Conclusion: Despite the abundant sunlight during summer, vitamin D status is a concern for mothers and children in Jordan.

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Which circulating level of 25-hydroxyvitamin D is appropriate?

Cited by 306 publications

References 26 publications

Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur

Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur

Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults

Assessment of serum 25(OH)D concentration in women of childbearing age and their preschool children in Northern Jordan during summer

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