Which data in the French registry for advanced chronic kidney disease for public health and patient care?

Caillet, Aurélie; Mazoue, Franck; Wurtz, Blandine; Larre, Xabina; Couchoud, Cécile; Lassalle, Mathilde; Moranne, Olivier

doi:10.1016/j.nephro.2022.01.004

Cited by 16 publications

(13 citation statements)

References 11 publications

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“…To better investigate the kidney transplantation access potential disparities between women and men in France, this research used a mixed methods approach that combines a quantitative study and a qualitative study [ 51 ]. The quantitative study describes and objectifies the factors associated with access to renal transplantation by analyzing data from the French national Renal Epidemiology and Information Network (REIN) [ 52 , 53 ] registry. The qualitative study will focus on the questions that cannot be assessed with a quantitative study (e.g., actors’ behaviors, action rationale, sense given to these actions) [ 51 , 54 , 55 ].…”

Section: Methodsmentioning

confidence: 99%

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Women’s Access to Kidney Transplantation in France: A Mixed Methods Research Protocol

Adoli

Raffray

Châtelet

et al. 2022

IJERPH

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Kidney transplantation is the best renal replacement therapy (medically and economically) for eligible patients with end-stage kidney disease. Studies in some French regions and in other countries suggest a lower access to the kidney transplant waiting listing and also to kidney transplantation, once waitlisted, for women. Using a mixed methods approach, this study aims to precisely understand these potential sex disparities and their causes. The quantitative study will explore the geographic disparities, compare the determinants of access to the waiting list and to kidney transplantation, and compare the reasons and duration of inactive status on the waiting list in women and men at different scales (national, regional, departmental, and census-block). The qualitative study will allow describing and comparing women’s and men’s views about their disease and transplantation, as well as nephrologists’ practices relative to the French national guidelines on waiting list registration. This type of study is important in the current societal context in which the reduction of sex/gender-based inequalities is a major social expectation.

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Section: Methodsmentioning

confidence: 99%

“…Data will be extracted from the REIN registry. This registry was started in 2002 and includes all patients with ESKD treated by RRT in France [ 52 , 53 , 59 ]. Since 2012, all mainland regions and overseas territories are included.…”

Section: Methodsmentioning

confidence: 99%

Women’s Access to Kidney Transplantation in France: A Mixed Methods Research Protocol

Adoli

Raffray

Châtelet

et al. 2022

IJERPH

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“…This study was based on the French Renal Epidemiology and Information Network (REIN), 28,29 the French national health insurance information system (Système National des Données de Santé: SNDS) and the histocompatibility laboratory of Nancy. Patients with KAF were identified by REIN as having graft failure requiring dialysis for more than 2 months.…”

Section: Study Populationmentioning

confidence: 99%

Evolution of HLA‐sensitization according to immunosuppressive therapy management among kidney transplant patients returning to dialysis between 2008 and 2019: A French retrospective study

Ferrari,

Aarnink,

Ayav

et al. 2023

Clinical Transplantation

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BackgroundThe optimal management of immunosuppressive therapy (IT) after kidney allograft failure (KAF) remains controversial. Although maintaining IT may reduce HLA‐sensitization and improve access to retransplantation, it may also increase the rate of immunosuppression‐related complications. The overall impact on patient mortality is unknown. The main objective of this study was to compare the evolution of HLA‐sensitization 6 months after KAF according to IT management.MethodsIndividual clinical and health care data were extracted from the French national end‐stage kidney disease registry (Renal Epidemiology and Information Network [REIN]) and the French National Health Data system (SNDS), respectively. Patients aged > 18 years returning to dialysis after KAF between January 2008 and December 2019 in Lorraine were included. Patients were classified into two groups, IT continuation or IT discontinuation. HLA‐sensitization was defined as an increase in incompatible graft rate (IGR) between KAF and 6 months post‐KAF (change to a higher predefined category (0%–5%), (5%–20%), (20%–50%), (50%–85%), (85%–95%), (95%–98%), (98%–100%)). Secondary outcome was patient survival according to IT management.ResultsA total of 121 patients were included, 35 (29%) of whom continued IT. HLA‐sensitization after KAF tended to be higher in the “IT discontinuation” group (57% vs. 38% in the “IT continuation” group, p = .07). In multivariate analysis, IT continuation was associated with a lower increase in IGR (OR .37, 95% CI [.14; .93]). IT management was not associated with patient mortality.ConclusionsContinuation of IT after KAF was associated with less change in IGR and was not associated with excess mortality.

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“…Details on methods and quality control have been described elsewhere. 24 The REIN registry and its utilization for research purposes have been approved by the relevant French ethics committees, specifically, the Comité consultatif sur le traitement de l'information en matière de recherche (CCTIRS) and the Commission nationale de l'informatique et des libertés (CNIL N° 903188). French regulations do not require participants' written or verbal informed consent for their inclusion in population-based registries requiring exhaustiveness.…”

Section: Study Sample and Data Collectionmentioning

confidence: 99%

First-line arteriovenous access and risks of hospitalization and death in patients starting hemodialysis – a nationwide cohort study

Pinho

Prézelin-Reydit

Harambat

et al. 2022

Preprint

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Arteriovenous (AV) access choice has sparked controversy with recent evidence suggesting overestimation of benefits associated with AV fistula versus graft in certain populations. We assessed outcomes associated with first-line AV access type in patients who started hemodialysis with a catheter in France, overall and by subgroups of age, sex, and comorbidities. In this retrospective cohort study, we included incident patients who initiated hemodialysis with a catheter from 2010 through 2018, followed by the French REIN Registry. Our main exposure was the first-line (first-created) AV graft versus fistula, ascertained through the linkage with the French national health-administrative database. Outcomes were all-cause and cause-specific hospitalization, and all-cause mortality. We used joint frailty models to deal with recurrent hospitalizations and informative censoring by death, Cox proportional hazard (PH) models, and inverse probability weighting. From the 18,625 patients included (mean age was 68±15 years, 35% were women), 5% had a first-line AV graft. Patients with AV graft had an 11%-higher weighted hazard of all-cause hospitalization (95% CI 1.09 to 1.13), 16% higher weighted hazard of cardiovascular (95% CI 1.05 to 1.29) and infection-related (95% CI 1.01 to 1.33) hospitalization, 34% higher weighted hazard of vascular access-related hospitalization, and a 9%-higher weighted hazard of all-cause death (95% CI 0.97 to 1.23). Results were consistent for most subgroups, except that the highest hazard of hospitalization with AV graft was blunted in patients with comorbidities (i.e. diabetes, weighted HR of all-cause hospitalization 1.03, 95% CI 0.95-1.12).- To conclude, in patients starting hemodialysis with a catheter, first-line AV graft is associated with increased hazard of hospitalization vs. patients with AV fistula. This may, however, not be the case for patients with a poor vascular condition, i.e., those with diabetes, who have a similar hospitalization and mortality rates with either graft or fistula.

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Which data in the French registry for advanced chronic kidney disease for public health and patient care?

Cited by 16 publications

References 11 publications

Women’s Access to Kidney Transplantation in France: A Mixed Methods Research Protocol

Women’s Access to Kidney Transplantation in France: A Mixed Methods Research Protocol

Evolution of HLA‐sensitization according to immunosuppressive therapy management among kidney transplant patients returning to dialysis between 2008 and 2019: A French retrospective study

First-line arteriovenous access and risks of hospitalization and death in patients starting hemodialysis – a nationwide cohort study

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